| Identification |
|---|
| HMDB Protein ID
| CDBP03372 |
| Secondary Accession Numbers
| Not Available |
| Name
| Paired mesoderm homeobox protein 2B |
| Description
| Not Available |
| Synonyms
|
- NBPhox
- Neuroblastoma Phox
- PHOX2B homeodomain protein
- Paired-like homeobox 2B
|
| Gene Name
| PHOX2B |
| Protein Type
| Transcription Factor |
| Biological Properties |
|---|
| General Function
| Involved in sequence-specific DNA binding transcription factor activity |
| Specific Function
| Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum- response element |
| GO Classification
|
| Component |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| nucleus |
| Function |
| binding |
| transcription regulator activity |
| nucleic acid binding |
| dna binding |
| sequence-specific dna binding |
| sequence-specific dna binding transcription factor activity |
| Process |
| regulation of gene expression |
| regulation of transcription |
| regulation of transcription, dna-dependent |
| biological regulation |
| regulation of biological process |
| regulation of metabolic process |
| regulation of macromolecule metabolic process |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:4 |
| Locus
| 4p12 |
| SNPs
| PHOX2B |
| Gene Sequence
|
>945 bp
ATGTATAAAATGGAATATTCTTACCTCAATTCCTCTGCCTACGAGTCCTGTATGGCTGGG
ATGGACACCTCGAGCCTGGCTTCAGCCTATGCTGACTTCAGTTCCTGCAGCCAGGCCAGT
GGCTTCCAGTATAACCCGATAAGGACCACTTTTGGGGCCACGTCCGGCTGCCCTTCCCTC
ACGCCGGGATCCTGCAGCCTGGGCACCCTCAGGGACCACCAGAGCAGTCCGTACGCCGCA
GTTCCTTACAAACTCTTCACGGACCACGGCGGCCTCAACGAGAAGCGCAAGCAGCGGCGC
ATCCGCACCACTTTCACCAGTGCCCAGCTCAAAGAGCTGGAAAGGGTCTTCGCGGAGACT
CACTACCCCGACATCTACACTCGGGAGGAGCTGGCCCTGAAGATCGACCTCACAGAGGCG
CGAGTCCAGGTGTGGTTCCAGAACCGCCGCGCCAAGTTTCGCAAGCAGGAGCGCGCAGCG
GCAGCCGCAGCGGCCGCGGCCAAGAACGGCTCCTCGGGCAAAAAGTCTGACTCTTCCAGG
GACGACGAGAGCAAAGAGGCCAAGAGCACTGACCCGGACAGCACTGGGGGCCCAGGTCCC
AATCCCAACCCCACCCCCAGCTGCGGGGCGAATGGAGGCGGCGGCGGCGGGCCCAGCCCG
GCTGGAGCTCCGGGGGCGGCGGGGCCCGGGGGCCCGGGAGGCGAACCCGGCAAGGGCGGC
GCAGCAGCAGCGGCGGCGGCCGCGGCAGCGGCGGCGGCGGCAGCGGCAGCGGCGGCAGCT
GGAGGCCTGGCTGCGGCTGGGGGCCCTGGACAAGGCTGGGCTCCCGGCCCCGGCCCCATC
ACCTCCATCCCGGATTCGCTTGGGGGTCCCTTCGGCAGCGTCCTATCTTCGCTCCAAAGA
CCCAACGGTGCCAAAGCCGCCTTAGTGAAGAGCAGTATGTTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 314 |
| Molecular Weight
| 31620.6 |
| Theoretical pI
| 9.1 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Paired mesoderm homeobox protein 2B
MYKMEYSYLNSSAYESCMAGMDTSSLASAYADFSSCSQASGFQYNPIRTTFGATSGCPSL
TPGSCSLGTLRDHQSSPYAAVPYKLFTDHGGLNEKRKQRRIRTTFTSAQLKELERVFAET
HYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAAAAAAAAAKNGSSGKKSDSSR
DDESKEAKSTDPDSTGGPGPNPNPTPSCGANGGGGGGPSPAGAPGAAGPGGPGGEPGKGG
AAAAAAAAAAAAAAAAAAAAGGLAAAGGPGQGWAPGPGPITSIPDSLGGPFASVLSSLQR
PNGAKAALVKSSMF
|
| External Links |
|---|
| GenBank ID Protein
| 5672611 |
| UniProtKB/Swiss-Prot ID
| Q99453 |
| UniProtKB/Swiss-Prot Entry Name
| PHX2B_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB015671 |
| GeneCard ID
| PHOX2B |
| GenAtlas ID
| PHOX2B |
| HGNC ID
| HGNC:9143 |
| References |
|---|
| General References
| Not Available |