| Identification |
|---|
| HMDB Protein ID
| CDBP03363 |
| Secondary Accession Numbers
| Not Available |
| Name
| Homeobox protein Meis1 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| MEIS1 |
| Protein Type
| Transcription Factor |
| Biological Properties |
|---|
| General Function
| Involved in sequence-specific DNA binding transcription factor activity |
| Specific Function
| Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias |
| GO Classification
|
| Function |
| sequence-specific dna binding transcription factor activity |
| binding |
| nucleic acid binding |
| dna binding |
| sequence-specific dna binding |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of metabolic process |
| regulation of macromolecule metabolic process |
| regulation of gene expression |
| regulation of transcription |
| regulation of transcription, dna-dependent |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2p14 |
| SNPs
| MEIS1 |
| Gene Sequence
|
>1173 bp
ATGGCGCAAAGGTACGACGATCTACCCCATTACGGGGGCATGGATGGAGTAGGCATCCCC
TCCACGATGTATGGGGACCCGCATGCAGCCAGGTCCATGCAGCCGGTCCACCACCTGAAC
CACGGGCCTCCTCTGCACTCGCATCAGTACCCGCACACAGCTCATACCAACGCCATGGCC
CCCAGCATGGGCTCCTCTGTCAATGACGCTTTAAAGAGAGATAAAGATGCCATTTATGGA
CACCCCCTCTTCCCTCTCTTAGCACTGATTTTTGAGAAATGTGAATTAGCTACTTGTACC
CCCCGCGAGCCGGGGGTGGCGGGCGGGGACGTCTGCTCGTCAGAGTCATTCAATGAAGAT
ATAGCCGTGTTCGCCAAACAGATTCGCGCAGAAAAACCTCTATTTTCTTCTAATCCAGAA
CTGGATAACTTGATGATTCAAGCCATACAAGTATTAAGGTTTCATCTATTGGAATTAGAG
AAGGTACACGAATTATGTGACAATTTCTGCCACCGGTATATTAGCTGTTTGAAAGGGAAA
ATGCCTATCGATTTGGTGATAGACGATAGAGAAGGAGGATCAAAATCAGACAGTGAAGAT
ATAACAAGATCAGCAAATCTAACTGACCAGCCCTCTTGGAACAGAGATCATGATGACACG
GCATCTACTCGTTCAGGAGGAACCCCAGGCCCTTCCAGCGGTGGCCACACGTCACACAGT
GGGGACAACAGCAGTGAGCAAGGTGATGGCTTGGACAACAGTGTAGCTTCCCCCAGCACA
GGTGACGATGATGACCCTGATAAGGACAAAAAGCGTCACAAAAAGCGTGGCATCTTTCCC
AAAGTAGCCACAAATATCATGAGGGCGTGGCTGTTCCAGCATCTAACACACCCTTACCCT
TCTGAAGAACAGAAAAAGCAGTTGGCACAAGACACGGGACTCACCATCCTTCAAGTGAAC
AATTGGTTTATTAATGCCCGGAGAAGAATAGTGCAGCCCATGATAGACCAGTCCAACCGA
GCAGTAAGTCAAGGAACACCTTATAATCCTGATGGACAGCCCATGGGAGGTTTCGTAATG
GACGGTCAGCAACATATGGGAATTAGAGCACCAGGACCTATGAGTGGAATGGGCATGAAT
ATGGGCATGGAGGGGCAGTGGCACTACATGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 390 |
| Molecular Weight
| 43015.8 |
| Theoretical pI
| 6.31 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Homeobox protein Meis1
MAQRYDDLPHYGGMDGVGIPSTMYGDPHAARSMQPVHHLNHGPPLHSHQYPHTAHTNAMA
PSMGSSVNDALKRDKDAIYGHPLFPLLALIFEKCELATCTPREPGVAGGDVCSSESFNED
IAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGK
MPIDLVIDDREGGSKSDSEDITRSANLTDQPSWNRDHDDTASTRSGGTPGPSSGGHTSHS
GDNSSEQGDGLDNSVASPSTGDDDDPDKDKKRHKKRGIFPKVATNIMRAWLFQHLTHPYP
SEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVM
DGQQHMGIRAPGPMSGMGMNMGMEGQWHYM
|
| External Links |
|---|
| GenBank ID Protein
| 4505151 |
| UniProtKB/Swiss-Prot ID
| O00470 |
| UniProtKB/Swiss-Prot Entry Name
| MEIS1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_002398.2 |
| GeneCard ID
| MEIS1 |
| GenAtlas ID
| MEIS1 |
| HGNC ID
| HGNC:7000 |
| References |
|---|
| General References
| Not Available |