| Identification |
|---|
| HMDB Protein ID
| CDBP03358 |
| Secondary Accession Numbers
| Not Available |
| Name
| Potassium voltage-gated channel subfamily H member 4 |
| Description
| Not Available |
| Synonyms
|
- BEC2
- Brain-specific eag-like channel 2
- ELK channel 1
- ELK1
- Ether-a-go-go-like potassium channel 1
- Voltage-gated potassium channel subunit Kv12.3
|
| Gene Name
| KCNH4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ion channel activity |
| Specific Function
| Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows no inactivation. Channel properties may be modulated by cAMP and subunit assembly |
| GO Classification
|
| Component |
| cell part |
| membrane |
| Function |
| potassium channel activity |
| catalytic activity |
| voltage-gated potassium channel activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| protein histidine kinase activity |
| two-component sensor activity |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| ion transmembrane transporter activity |
| molecular transducer activity |
| signal transducer activity |
| protein kinase activity |
| transporter activity |
| ion channel activity |
| cation channel activity |
| Process |
| transmembrane transport |
| monovalent inorganic cation transport |
| potassium ion transport |
| signaling process |
| ion transport |
| signal transmission |
| cation transport |
| two-component signal transduction system (phosphorelay) |
| establishment of localization |
| transport |
| biological regulation |
| regulation of biological process |
| regulation of metabolic process |
| regulation of macromolecule metabolic process |
| regulation of gene expression |
| regulation of transcription |
| regulation of transcription, dna-dependent |
| regulation of cellular process |
| signal transduction |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 17q21.2 |
| SNPs
| KCNH4 |
| Gene Sequence
|
>3054 bp
ATGCCGGTCATGAAGGGGTTGCTGGCCCCGCAAAACACCTTCCTGGACACCATCGCCACC
CGTTTTGACGGAACGCACAGCAACTTCCTGCTGGCCAACGCACAGGGCACACGGGGCTTT
CCCATCGTCTACTGCTCCGACGGCTTCTGCGAGCTCACAGGCTACGGTCGCACCGAGGTC
ATGCAGAAGACCTGCAGCTGCCGTTTCCTCTACGGCCCAGAGACCAGTGAGCCAGCCCTG
CAGCGTCTGCACAAAGCCCTGGAGGGCCACCAGGAGCACCGGGCTGAAATCTGCTTCTAC
CGCAAGGATGGCTCAGCCTTTTGGTGCCTCCTGGACATGATGCCCATCAAGAATGAGATG
GGGGAGGTCGTGCTGTTCCTCTTTTCCTTCAAGGATATCACTCAGAGTGGAAGCCCAGGA
CTTGGCCCCCAAGGAGGCCGCGGGGACAGTAATCACGAAAACTCCCTTGGTAGAAGGGGA
GCCACCTGGAAATTTCGGTCTGCCAGAAGACGGAGCCGTACTGTCCTACACCGACTGACC
GGCCACTTTGGCCGCCGGGGCCAGGGAGGCATGAAGGCCAATAATAACGTGTTTGAGCCA
AAGCCATCAGTGCCCGAGTACAAGGTGGCCTCCGTGGGGGGGTCTCGCTGCCTCCTCCTC
CACTACAGCGTCTCCAAGGCCATCTGGGACGGCCTTATCCTCCTTGCCACCTTCTACGTT
GCGGTCACCGTCCCCTACAATGTCTGTTTCTCGGGTGACGATGACACCCCCATCACTTCG
CGACACACCCTTGTCAGCGACATCGCCGTGGAAATGCTCTTCATCCTAGATATCATCCTG
AACTTCCGCACCACCTATGTGTCCCAGTCCGGCCAGGTAATCTCTGCTCCTCGTTCCATT
GGCCTCCACTACCTGGCCACCTGGTTCTTCATCGACCTTATTGCTGCTCTGCCCTTTGAC
CTGCTTTACATCTTCAACATCACCGTGACCTCGCTGGTGCACCTACTGAAGACAGTGCGG
CTGTTGCGGCTGCTGCGGCTGCTGCAGAAGCTGGAGCGGTACTCTCAGTGCAGTGCTGTG
GTGCTCACGCTGCTCATGTCGGTCTTTGCGCTCCTTGCCCACTGGATGGCCTGCATCTGG
TATGTCATCGGGCGCCGGGAGATGGAGGCCAATGACCCGCTGCTCTGGGACATTGGCTGG
TTGCATGAGTTGGGCAAGCGTCTGGAGGTGCCCTATGTCAATGGCTCGGTGGGCGGCCCA
TCACGGCGCAGCGCCTACATCGCGGCACTGTACTTCACTCTAAGCAGCCTCACCAGTGTG
GGCTTTGGCAACGTGTGTGCCAACACCGACGCGGAGAAGATCTTCTCCATCTGCACGATG
CTCATAGGCGCCCTGATGCACGCTGTGGTGTTCGGGAACGTGACAGCCATCATCCAGCGC
ATGTACTCGCGCCGCTCGCTCTACCACAGCCGCATGAAGGACCTCAAGGACTTCATCCGT
GTGCACCGCCTGCCGCGGCCGCTCAAGCAGCGCATGCTCGAATACTTCCAGACCACGTGG
GCCGTCAACAGCGGCATCGACGCCAACGAGTTACTGCGTGACTTCCCAGACGAGCTGAGA
GCTGACATTGCTATGCACCTGAATCGGGAGATCCTGCAGCTGCCGTTGTTCGGGGCAGCG
AGCAGGGGCTGCCTGCGGGCCCTATCGCTGCACATCAAGACCTCGTTCTGCGCTCCGGGC
GAGTACCTGTTGCGCCGTGGGGATGCCCTGCAGGCACATTACTATGTCTGCTCCGGCTCG
CTTGAGGTGCTCCGAGACAACATGGTGCTGGCCATCCTGGGGAAGGGGGACCTGATTGGA
GCAGATATCCCTGAGCCGGGGCAGGAGCCTGGGTTGGGAGCAGACCCAAACTTCGTGCTA
AAGACCAGTGCTGATGTGAAAGCTCTGACCTACTGTGGCCTGCAGCAGCTGAGCAGCCGA
GGGCTGGCTGAGGTCCTGAGGCTCTATCCTGAGTATGGGGCTGCCTTCCGGGCTGGCCTG
CCCCGGGACCTCACCTTCAACCTGCGCCAGGGCTCTGACACCAGTGGCCTCAGCCGCTTT
TCCCGATCCCCTCGCCTCTCCCAGCCCCGCTCAGAAAGCCTCGGCTCCTCCTCAGACAAG
ACGCTGCCATCCATCACAGAGGCCGAGAGTGGCGCGGAGCCTGGGGGTGGTCCCAGGCCC
CGACGGCCCCTCCTGCTGCCCAACCTCAGCCCAGCACGGCCTCGGGGCTCCCTGGTCAGC
CTTTTGGGCGAGGAGCTGCCCCCATTCTCAGCCCTTGTCTCCTCTCCTTCCTTATCCCCA
TCCCTGTCCCCTGCCCTGGCTGGCCAGGGCCACAGTGCCTCCCCTCACGGCCCCCCCAGG
TGCTCTGCTGCCTGGAAGCCCCCTCAGCTTCTCATTCCCCCACTGGGAACCTTTGGACCT
CCGGACCTCAGTCCCCGGATAGTGGATGGCATTGAGGACTCTGGCAGCACAGCTGAGGCC
CCTTCATTCCGATTCAGCAGGAGGCCTGAACTGCCAAGGCCCCGCTCCCAGGCGCCCCCT
ACAGGGACCAGGCCCAGCCCAGAATTGGCCAGTGAGGCTGAGGAGGTGAAGGAAAAGGTT
TGCCGGCTGAACCAGGAGATCTCTCGTCTCAATCAGGAGGTGTCTCAGCTTAGCCGGGAG
CTGCGGCACATCATGGGCCTGCTGCAGGCCAGGCTGGGTCCCCCAGGCCACCCAGCAGGC
TCCGCTTGGACCCCAGACCCTCCTTGTCCACAGCTGAGGCCACCATGCCTCTCTCCTTGT
GCGTCCAGACCACCACCCAGCCTCCAGGATACTACGCTTGCTGAAGTTCACTGCCCAGCC
AGTGTGGGGACCATGGAGACAGGGACTGCGCTCCTGGACTTGAGACCTTCCATATTGCCC
CCCTACCCCTCAGAGCCTGACCCTCTGGGACCCTCTCCAGTGCCAGAGGCCTCACCCCCA
ACCCCAAGCCTCTTGAGGCACAGTTTCCAGTCCAGGTCAGACACGTTCCACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1017 |
| Molecular Weight
| 111692.1 |
| Theoretical pI
| 8.63 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["229-249", "260-280", "303-323", "333-353", "362-382", "483-503"]
|
| Protein Sequence
|
>Potassium voltage-gated channel subfamily H member 4
MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEV
MQKTCSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEM
GEVVLFLFSFKDITQSGSPGLGPQGGRGDSNHENSLGRRGATWKFRSARRRSRTVLHRLT
GHFGRRGQGGMKANNNVFEPKPSVPEYKVASVGGSRCLLLHYSVSKAIWDGLILLATFYV
AVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSI
GLHYLATWFFIDLIAALPFDLLYIFNITVTSLVHLLKTVRLLRLLRLLQKLERYSQCSAV
VLTLLMSVFALLAHWMACIWYVIGRREMEANDPLLWDIGWLHELGKRLEVPYVNGSVGGP
SRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQR
MYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELR
ADIAMHLNREILQLPLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGS
LEVLRDNMVLAILGKGDLIGADIPEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSSR
GLAEVLRLYPEYGAAFRAGLPRDLTFNLRQGSDTSGLSRFSRSPRLSQPRSESLGSSSDK
TLPSITEAESGAEPGGGPRPRRPLLLPNLSPARPRGSLVSLLGEELPPFSALVSSPSLSP
SLSPALAGQGHSASPHGPPRCSAAWKPPQLLIPPLGTFGPPDLSPRIVDGIEDSGSTAEA
PSFRFSRRPELPRPRSQAPPTGTRPSPELASEAEEVKEKVCRLNQEISRLNQEVSQLSRE
LRHIMGLLQARLGPPGHPAGSAWTPDPPCPQLRPPCLSPCASRPPPSLQDTTLAEVHCPA
SVGTMETGTALLDLRPSILPPYPSEPDPLGPSPVPEASPPTPSLLRHSFQSRSDTFH
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9UQ05 |
| UniProtKB/Swiss-Prot Entry Name
| KCNH4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB022698 |
| GeneCard ID
| KCNH4 |
| GenAtlas ID
| KCNH4 |
| HGNC ID
| HGNC:6253 |
| References |
|---|
| General References
| Not Available |