| Identification |
|---|
| HMDB Protein ID
| CDBP03357 |
| Secondary Accession Numbers
| Not Available |
| Name
| Potassium voltage-gated channel subfamily H member 3 |
| Description
| Not Available |
| Synonyms
|
- BEC1
- Brain-specific eag-like channel 1
- ELK channel 2
- ELK2
- Ether-a-go-go-like potassium channel 2
- Voltage-gated potassium channel subunit Kv12.2
|
| Gene Name
| KCNH3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ion channel activity |
| Specific Function
| Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Function |
| protein kinase activity |
| transporter activity |
| ion channel activity |
| cation channel activity |
| potassium channel activity |
| catalytic activity |
| voltage-gated potassium channel activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| protein histidine kinase activity |
| two-component sensor activity |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| ion transmembrane transporter activity |
| molecular transducer activity |
| signal transducer activity |
| Process |
| regulation of transcription |
| regulation of transcription, dna-dependent |
| regulation of cellular process |
| signal transduction |
| transmembrane transport |
| monovalent inorganic cation transport |
| potassium ion transport |
| signaling process |
| ion transport |
| signal transmission |
| cation transport |
| two-component signal transduction system (phosphorelay) |
| establishment of localization |
| transport |
| biological regulation |
| regulation of biological process |
| regulation of metabolic process |
| regulation of macromolecule metabolic process |
| regulation of gene expression |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12q13 |
| SNPs
| KCNH3 |
| Gene Sequence
|
>3252 bp
ATGCCGGCCATGCGGGGCCTCCTGGCGCCTCAGAACACCTTCCTGGACACCATCGCTACG
CGCTTCGACGGCACGCACAGTAACTTCGTGCTGGGCAACGCCCAGGTGGCGGGGCTCTTC
CCCGTGGTCTACTGCTCTGATGGCTTCTGTGACCTCACGGGCTTCTCCCGGGCTGAGGTC
ATGCAGCGGGGCTGTGCCTGCTCCTTCCTTTATGGGCCAGACACCAGTGAGCTCGTCCGC
CAACAGATCCGCAAGGCCCTGGACGAGCACAAGGAGTTCAAGGCTGAGCTGATCCTGTAC
CGGAAGAGCGGGCTCCCGTTCTGGTGTCTCCTGGATGTGATACCCATAAAGAATGAGAAA
GGGGAGGTGGCTCTCTTCCTAGTCTCTCACAAGGACATCAGCGAAACCAAGAACCGAGGG
GGCCCCGACAGATGGAAGGAGACAGGTGGTGGCCGGCGCCGATATGGCCGGGCACGATCC
AAAGGCTTCAATGCCAACCGGCGGCGGAGCCGGGCCGTGCTCTACCACCTGTCCGGGCAC
CTGCAGAAGCAGCCCAAGGGCAAGCACAAGCTCAATAAGGGGGTGTTTGGGGAGAAACCA
AACTTGCCTGAGTACAAAGTAGCCGCCATCCGGAAGTCGCCCTTCATCCTGTTGCACTGT
GGGGCACTGAGAGCCACCTGGGATGGCTTCATCCTGCTCGCCACACTCTATGTGGCTGTC
ACTGTGCCCTACAGCGTGTGTGTGAGCACAGCACGGGAGCCCAGTGCCGCCCGCGGCCCG
CCCAGCGTCTGTGACCTGGCCGTGGAGGTCCTCTTCATCCTTGACATTGTGCTGAATTTC
CGTACCACATTCGTGTCCAAGTCGGGCCAGGTGGTGTTTGCCCCAAAGTCCATTTGCCTC
CACTACGTCACCACCTGGTTCCTGCTGGATGTCATCGCAGCGCTGCCCTTTGACCTGCTA
CATGCCTTCAAGGTCAACGTGTACTTCGGGGCCCATCTGCTGAAGACGGTGCGCCTGCTG
CGCCTGCTGCGCCTGCTTCCGCGGCTGGACCGGTACTCGCAGTACAGCGCCGTGGTGCTG
ACACTGCTCATGGCCGTGTTCGCCCTGCTCGCGCACTGGGTCGCCTGCGTCTGGTTTTAC
ATTGGCCAGCGGGAGATCGAGAGCAGCGAATCCGAGCTGCCTGAGATTGGCTGGCTGCAG
GAGCTGGCCCGCCGACTGGAGACTCCCTACTACCTGGTGGGCCGGAGGCCAGCTGGAGGG
AACAGCTCCGGCCAGAGTGACAACTGCAGCAGCAGCAGCGAGGCCAACGGGACGGGGCTG
GAGCTGCTGGGCGGCCCGTCGCTGCGCAGCGCCTACATCACCTCCCTCTACTTCGCACTC
AGCAGCCTCACCAGCGTGGGCTTCGGCAACGTGTCCGCCAACACGGACACCGAGAAGATC
TTCTCCATCTGCACCATGCTCATCGGCGCCCTGATGCACGCGGTGGTGTTTGGGAACGTG
ACGGCCATCATCCAGCGCATGTACGCCCGCCGCTTTCTGTACCACAGCCGCACGCGCGAC
CTGCGCGACTACATCCGCATCCACCGTATCCCCAAGCCCCTCAAGCAGCGCATGCTGGAG
TACTTCCAGGCCACCTGGGCGGTGAACAATGGCATCGACACCACCGAGCTGCTGCAGAGC
CTCCCTGACGAGCTGCGCGCAGACATCGCCATGCACCTGCACAAGGAGGTCCTGCAGCTG
CCACTGTTTGAGGCGGCCAGCCGCGGCTGCCTGCGGGCACTGTCTCTGGCCCTGCGGCCC
GCCTTCTGCACGCCGGGCGAGTACCTCATCCACCAAGGCGATGCCCTGCAGGCCCTCTAC
TTTGTCTGCTCTGGCTCCATGGAGGTGCTCAAGGGTGGCACCGTGCTCGCCATCCTAGGG
AAGGGCGACCTGATCGGCTGTGAGCTGCCCCGGCGGGAGCAGGTGGTAAAGGCCAATGCC
GACGTGAAGGGGCTGACGTACTGCGTCCTGCAGTGTCTGCAGCTGGCTGGCCTGCACGAC
AGCCTTGCGCTGTACCCCGAGTTTGCCCCGCGCTTCAGTCGTGGCCTCCGAGGGGAGCTC
AGCTACAACCTGGGTGCTGGGGGAGGCTCTGCAGAGGTGGACACCAGCTCCCTGAGCGGC
GACAATACCCTTATGTCCACGCTGGAGGAGAAGGAGACAGATGGGGAGCAGGGCCCCACG
GTCTCCCCAGCCCCAGCTGATGAGCCCTCCAGCCCCCTGCTGTCCCCTGGCTGCACCTCC
TCATCCTCAGCTGCCAAGCTGCTATCCCCACGTCGAACAGCACCCCGGCCTCGTCTAGGT
GGCAGAGGGAGGCCAGGCAGGGCAGGGGCTTTGAAGGCTGAGGCTGGCCCCTCTGCTCCC
CCACGGGCCCTAGAGGGGCTACGGCTGCCCCCCATGCCATGGAATGTGCCCCCAGATCTG
AGCCCCAGGGTAGTAGATGGCATTGAAGACGGCTGTGGCTCGGACCAGCCCAAGTTCTCT
TTCCGCGTGGGCCAGTCTGGCCCGGAATGTAGCAGCAGCCCCTCCCCTGGACCAGAGAGC
GGCCTGCTCACTGTTCCCCATGGGCCCAGCGAGGCAAGGAACACAGACACACTGGACAAG
CTTCGGCAGGCGGTGACAGAGCTGTCAGAGCAGGTGCTGCAGATGCGGGAAGGACTGCAG
TCACTTCGCCAGGCTGTGCAGCTTGTCCTGGCGCCCCACAGGGAGGGTCCGTGCCCTCGG
GCATCGGGAGAGGGGCCGTGCCCAGCCAGCACCTCCGGGCTTCTGCAGCCTCTGTGTGTG
GACACTGGGGCATCCTCCTACTGCCTGCAGCCCCCAGCTGGCTCTGTCTTGAGTGGGACT
TGGCCCCACCCTCGTCCGGGGCCTCCTCCCCTCATGGCACCCTGGCCCTGGGGTCCCCCA
GCGTCTCAGAGCTCCCCCTGGCCTCGAGCCACAGCTTTCTGGACCTCCACCTCAGACTCA
GAGCCCCCTGCCTCAGGAGACCTCTGCTCTGAGCCCAGCACCCCTGCCTCCCCTCCTCCT
TCTGAGGAAGGGGCTAGGACTGGGCCCGCAGAGCCTGTGAGCCAGGCTGAGGCTACCAGC
ACTGGAGAGCCCCCACCAGGGTCAGGGGGCCTGGCCTTGCCCTGGGACCCCCACAGCCTG
GAGATGGTGCTTATTGGCTGCCATGGCTCTGGCACAGTCCAGTGGACCCAGGAAGAAGGC
ACAGGGGTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1083 |
| Molecular Weight
| 117127.7 |
| Theoretical pI
| 7.98 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["229-249", "260-280", "303-323", "332-352", "362-382", "480-500"]
|
| Protein Sequence
|
>Potassium voltage-gated channel subfamily H member 3
MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEV
MQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEK
GEVALFLVSHKDISETKNRGGPDRWKETGGGRRRYGRARSKGFNANRRRSRAVLYHLSGH
LQKQPKGKHKLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAV
TVPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICL
HYVTTWFLLDVIAALPFDLLHAFKVNVYFGAHLLKTVRLLRLLRLLPRLDRYSQYSAVVL
TLLMAVFALLAHWVACVWFYIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGG
NSSGQSDNCSSSSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKI
FSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLE
YFQATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVLQLPLFEAASRGCLRALSLALRP
AFCTPGEYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPRREQVVKANA
DVKGLTYCVLQCLQLAGLHDSLALYPEFAPRFSRGLRGELSYNLGAGGGSAEVDTSSLSG
DNTLMSTLEEKETDGEQGPTVSPAPADEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLG
GRGRPGRAGALKAEAGPSAPPRALEGLRLPPMPWNVPPDLSPRVVDGIEDGCGSDQPKFS
FRVGQSGPECSSSPSPGPESGLLTVPHGPSEARNTDTLDKLRQAVTELSEQVLQMREGLQ
SLRQAVQLVLAPHREGPCPRASGEGPCPASTSGLLQPLCVDTGASSYCLQPPAGSVLSGT
WPHPRPGPPPLMAPWPWGPPASQSSPWPRATAFWTSTSDSEPPASGDLCSEPSTPASPPP
SEEGARTGPAEPVSQAEATSTGEPPPGSGGLALPWDPHSLEMVLIGCHGSGTVQWTQEEG
TGV
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9ULD8 |
| UniProtKB/Swiss-Prot Entry Name
| KCNH3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB022696 |
| GeneCard ID
| KCNH3 |
| GenAtlas ID
| KCNH3 |
| HGNC ID
| HGNC:6252 |
| References |
|---|
| General References
| Not Available |