| Identification |
|---|
| HMDB Protein ID
| CDBP03350 |
| Secondary Accession Numbers
| Not Available |
| Name
| Jun dimerization protein 2 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| JDP2 |
| Protein Type
| Transcription Factor |
| Biological Properties |
|---|
| General Function
| Involved in sequence-specific DNA binding transcription factor activity |
| Specific Function
| Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin |
| GO Classification
|
| Component |
| nucleus |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| Function |
| binding |
| protein binding |
| nucleic acid binding |
| dna binding |
| protein dimerization activity |
| sequence-specific dna binding |
| sequence-specific dna binding transcription factor activity |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of metabolic process |
| regulation of macromolecule metabolic process |
| regulation of gene expression |
| regulation of transcription |
| regulation of transcription, dna-dependent |
|
| Cellular Location
|
- Nucleus (Probable)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 14q24.3 |
| SNPs
| JDP2 |
| Gene Sequence
|
>492 bp
ATGATGCCTGGACAGATCCCGGACCCTTCGGTGACCACAGGCTCCCTGCCAGGGCTTGGC
CCCCTGACCGGGCTCCCCAGCTCGGCCCTGACTGTGGAGGAGCTGAAATACGCTGACATC
CGCAACCTCGGGGCCATGATTGCACCCTTGCACTTCCTGGAGGTGAAACTGGGCAAGAGG
CCCCAGCCCGTGAAAAGTGAGCTAGATGAGGAAGAGGAGCGAAGGAAAAGGCGCCGGGAG
AAGAACAAAGTCGCAGCAGCCCGATGCCGGAACAAGAAGAAGGAGCGCACGGAGTTTCTG
CAGCGGGAATCCGAGCGGCTGGAACTCATGAACGCAGAGCTGAAGACCCAGATTGAGGAG
CTGAAGCAGGAGCGGCAGCAGCTCATCCTGATGCTGAACCGACACCGCCCCACCTGCATC
GTCCGGACCGACAGTGTCAAGACCCCCGAGTCAGAAGGCAACCCACTGCTCGAGCAGCTC
GAGAAGAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 163 |
| Molecular Weight
| 18703.5 |
| Theoretical pI
| 9.9 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Jun dimerization protein 2
MMPGQIPDPSVTTGSLPGLGPLTGLPSSALTVEELKYADIRNLGAMIAPLHFLEVKLGKR
PQPVKSELDEEEERRKRRREKNKVAAARCRNKKKERTEFLQRESERLELMNAELKTQIEE
LKQERQQLILMLNRHRPTCIVRTDSVKTPESEGNPLLEQLEKK
|
| External Links |
|---|
| GenBank ID Protein
| 18181974 |
| UniProtKB/Swiss-Prot ID
| Q8WYK2 |
| UniProtKB/Swiss-Prot Entry Name
| JDP2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB077880 |
| GeneCard ID
| JDP2 |
| GenAtlas ID
| JDP2 |
| HGNC ID
| HGNC:17546 |
| References |
|---|
| General References
| Not Available |