| Identification |
|---|
| HMDB Protein ID
| CDBP03346 |
| Secondary Accession Numbers
| Not Available |
| Name
| Histamine H4 receptor |
| Description
| Not Available |
| Synonyms
|
- AXOR35
- G-protein coupled receptor 105
- GPRv53
- H4R
- HH4R
- Pfi-013
- SP9144
|
| Gene Name
| HRH4 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor protein signaling pathway |
| Specific Function
| The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist) |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Process |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
| signaling |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 18q11.2 |
| SNPs
| HRH4 |
| Gene Sequence
|
>1173 bp
ATGCCAGATACTAATAGCACAATCAATTTATCACTAAGCACTCGTGTTACTTTAGCATTT
TTTATGTCCTTAGTAGCTTTTGCTATAATGCTAGGAAATGCTTTGGTCATTTTAGCTTTT
GTGGTGGACAAAAACCTTAGACATCGAAGTAGTTATTTTTTTCTTAACTTGGCCATCTCT
GACTTCTTTGTGGGTGTGATCTCCATTCCTTTGTACATCCCTCACACGCTGTTCGAATGG
GATTTTGGAAAGGAAATCTGTGTATTTTGGCTCACTACTGACTATCTGTTATGTACAGCA
TCTGTATATAACATTGTCCTCATCAGCTATGATCGATACCTGTCAGTCTCAAATGCTGTG
TCTTATAGAACTCAACATACTGGGGTCTTGAAGATTGTTACTCTGATGGTGGTCGTTTGG
GTGCTGGCCTTCTTAGTGAATGGGCCAATGATTCTAGTTTCAGAGTCTTGGAAGGATGAA
GGTAGTGAATGTGAACCTGGATTTTTTTCGGAATGGTACATCCTTGCCATCACATCATTC
TTGGAATTCGTGATCCCAGTCATCTTAGTCGCTTATTTCAACATGAATATTTATTGGAGC
CTGTGGAAGCGTGATCGTCTCAGTAGGTGCCAAAGCCATCCTGGACTGACTGCTGTCTCT
TCCAACATCTGTGGACACTCATTCAGAGGTAGACTATCTTCAAGGAGATCTCTTTCTGCA
TCGACAGAAGTTCCTGCATCCTTTCATTCAGAGAGACGGAGGAGAAAGAGTAGTCTCATG
TTTTCCTCAAGAACCAAGATGAATAGCAATACAATTGCTTCCAAAATGGGTTCCTTCTCC
CAATCAGATTCTGTAGCTCTTCACCAAAGGGAACATGTTGAACTGCTTAGAGCCAGGAGA
TTAGCCAAGTCACTGGCCATTCTCTTAGGGGTTTTTGCTGTTTGCTGGGCTCCATATTCT
CTGTTCACAATTGTCCTTTCATTTTATTCCTCAGCAACAGGTCCTAAATCAGTTTGGTAT
AGAATTGCATTTTGGCTTCAGTGGTTCAATTCCTTTGTCAATCCTCTTTTGTATCCATTG
TGTCACAAGCGCTTTCAAAAGGCTTTCTTGAAAATATTTTGTATAAAAAAGCAACCTCTA
CCATCACAACACAGTCGGTCAGTATCTTCTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 390 |
| Molecular Weight
| 44495.4 |
| Theoretical pI
| 9.92 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["20-40", "53-73", "88-108", "132-152", "173-193", "305-325", "342-362"]
|
| Protein Sequence
|
>Histamine H4 receptor
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
|
| External Links |
|---|
| GenBank ID Protein
| 10241847 |
| UniProtKB/Swiss-Prot ID
| Q9H3N8 |
| UniProtKB/Swiss-Prot Entry Name
| HRH4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB044934 |
| GeneCard ID
| HRH4 |
| GenAtlas ID
| HRH4 |
| HGNC ID
| HGNC:17383 |
| References |
|---|
| General References
| Not Available |