Cannabis Compound Database: Showing Protein Cyclic AMP-responsive element-binding protein 3 (CDBP03336)

Identification Biological properties Gene properties Protein properties External links References XML Show 0 compounds

Identification

HMDB Protein ID

CDBP03336

Secondary Accession Numbers

Not Available

Name

Cyclic AMP-responsive element-binding protein 3

Description

Not Available

Synonyms

CREB-3
Luman
Processed cyclic AMP-responsive element-binding protein 3
Transcription factor LZIP-alpha
cAMP-responsive element-binding protein 3

Gene Name

CREB3

Protein Type

Transcription Factor

Biological Properties

General Function

Involved in sequence-specific DNA binding transcription factor activity

Specific Function

Transcription factors activated upon intramembrane proteolysis (RIP), binds the cAMP response element (CRE) (consensus:5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Binds to and requires HCFC1 as a coactivator. Activity and expression are suppressed when the HCFC1-CREB3 complex binds with CREBZF. Participates in LKN- 1/CCL15-induced chemotaxis signaling

GO Classification

Function
binding
protein binding
nucleic acid binding
dna binding
protein dimerization activity
sequence-specific dna binding
sequence-specific dna binding transcription factor activity
Process
regulation of gene expression
regulation of transcription
regulation of transcription, dna-dependent
biological regulation
regulation of biological process
regulation of metabolic process
regulation of macromolecule metabolic process

Cellular Location

Processed cyclic AMP-responsive element- binding protein 3:Nucleus

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:9

Locus

9p13.3

SNPs

CREB3

Gene Sequence

>1188 bp
ATGGAGCTGGAATTGGATGCTGGTGACCAAGACCTGCTGGCCTTCCTGCTAGAGGAAAGT
GGAGATTTGGGGACGGCACCCGATGAGGCCGTGAGGGCCCCACTGGACTGGGCGCTGCCG
CTTTCTGAGGTACCGAGCGACTGGGAAGTAGATGATTTGCTGTGCTCCCTGCTGAGTCCC
CCAGCGTCGTTGAACATTCTCAGCTCCTCCAACCCCTGCCTTGTCCACCATGACCACACC
TACTCCCTCCCACGGGAAACTGTCTCTATGGATCTAGGTGAGTGTGAAATAAGTTTGACG
GGGAGGACAGGGTTCATGGGCCTGGCTATTCATACTTTCCCTTTTGCAGAGAGTGAGAGC
TGTAGAAAAGAGGGGACCCAGATGACTCCACAGCATATGGAGGAGCTGGCAGAGCAGGAG
ATTGCTAGGCTAGTACTGACAGATGAGGAGAAGAGTCTATTGGAGAAGGAGGGGCTTATT
CTGCCTGAGACACTTCCTCTCACTAAGACAGAGGAACAAATTCTGAAACGTGTGCGGAGG
AAGATTCGAAATAAAAGATCTGCTCAAGAGAGCCGCAGGAAAAAGAAGGTGTATGTTGGG
GGTTTAGAGAGCAGGGTCTTGAAATACACAGCCCAGAATATGGAGCTTCAGAACAAAGTA
CAGCTTCTGGAGGAACAGAATTTGTCCCTTCTAGATCAACTGAGGAAACTCCAGGCCATG
GTGATTGAGATATCAAACAAAACCAGCAGCAGCAGCACCTGCATCTTGGTCCTACTAGTC
TCCTTCTGCCTCCTCCTTGTACCTGCTATGTACTCCTCTGACACAAGGGGGAGCCTGCCA
GCTGAGCATGGAGTGTTGTCCCGCCAGCTTCGTGCCCTCCCCAGTGAGGACCCTTACCAG
CTGGAGCTGCCTGCCCTGCAGTCAGAAGTGCCGAAAGACAGCACACACCAGTGGTTGGAC
GGCTCAGACTGTGTACTCCAGGCCCCTGGCAACACTTCCTGCCTGCTGCATTACATGCCT
CAGGCTCCCAGTGCAGAGCCTCCCCTGGAGTGGCCATTCCCTGACCTCTTCTCAGAGCCT
CTCTGCCGAGGTCCCATCCTCCCCCTGCAGGCAAATCTCACAAGGAAGGGAGGATGGCTT
CCTACTGGTAGCCCCTCTGTCATTTTGCAGGACAGATACTCAGGCTAG

Protein Properties

Number of Residues

395

Molecular Weight

43916.7

Theoretical pI

4.57

Pfam Domain Function

bZIP_1 (PF00170 )

Signals

["None"]

Transmembrane Regions

["255-271"]

Protein Sequence

>Cyclic AMP-responsive element-binding protein 3
MELELDAGDQDLLAFLLEESGDLGTAPDEAVRAPLDWALPLSEVPSDWEVDDLLCSLLSP
PASLNILSSSNPCLVHHDHTYSLPRETVSMDLGECEISLTGRTGFMGLAIHTFPFAESES
CRKEGTQMTPQHMEELAEQEIARLVLTDEEKSLLEKEGLILPETLPLTKTEEQILKRVRR
KIRNKRSAQESRRKKKVYVGGLESRVLKYTAQNMELQNKVQLLEEQNLSLLDQLRKLQAM
VIEISNKTSSSSTCILVLLVSFCLLLVPAMYSSDTRGSLPAEHGVLSRQLRALPSEDPYQ
LELPALQSEVPKDSTHQWLDGSDCVLQAPGNTSCLLHYMPQAPSAEPPLEWPFPDLFSEP
LCRGPILPLQANLTRKGGWLPTGSPSVILQDRYSG

External Links

GenBank ID Protein

2911282

UniProtKB/Swiss-Prot ID

O43889

UniProtKB/Swiss-Prot Entry Name

CREB3_HUMAN

PDB IDs

Not Available

GenBank Gene ID

U88528

GeneCard ID