Cannabis Compound Database: Showing Protein Cyclic nucleotide-gated olfactory channel (CDBP03332)

Identification Biological properties Gene properties Protein properties External links References XML Show 0 compounds

Identification

HMDB Protein ID

CDBP03332

Secondary Accession Numbers

Not Available

Name

Cyclic nucleotide-gated olfactory channel

Description

Not Available

Synonyms

CNG channel alpha-2
CNG-2
CNG2
Cyclic nucleotide-gated cation channel 2
Cyclic nucleotide-gated channel alpha-2

Gene Name

CNGA2

Protein Type

Transporter

Biological Properties

General Function

Involved in ion channel activity

Specific Function

Odorant signal transduction is probably mediated by a G- protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons

GO Classification

Component
membrane
cell part
Function
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
transporter activity
ion channel activity
Process
establishment of localization
transport
transmembrane transport
ion transport

Cellular Location

Membrane
Multi-pass membrane protein

Pathways

Not Available

Gene Properties

Chromosome Location

Not Available

Locus

Not Available

SNPs

CNGA2

Gene Sequence

>1995 bp
ATGACCGAAAAAACCAATGGTGTGAAGAGCTCCCCAGCCAATAATCACAACCATCATGCA
CCTCCTGCCATCAAGGCCAATGGCAAAGATGACCACAGGACAAGCAGCAGGCCACACTCT
GCAGCTGACGATGACACCTCCTCAGAACTGCAGAGGCTGGCAGACGTGGATGCCCCACAG
CAGGGAAGGAGTGGCTTCCGCAGGATAGTTCGCCTGGTGGGGATCATCAGAGAATGGGCC
AACAAGAATTTCCGAGAGGAGGAACCTAGGCCTGACTCATTCCTCGAGCGTTTTCGTGGG
CCTGAACTCCAGACTGTGACCACACAGGAGGGGGATGGCAAAGGCGACAAGGATGGCGAG
GACAAAGGCACCAAGAAGAAATTTGAACTATTTGTCTTGGACCCAGCTGGGGATTGGTAC
TACTGCTGGCTATTTGTCATTGCCATGCCCGTCCTTTACAACTGGTGCCTGCTGGTGGCC
AGAGCCTGCTTCAGTGACCTACAGAAAGGCTACTACCTGGTGTGGCTGGTGCTGGATTAT
GTCTCAGATGTGGTCTACATTGCGGACCTCTTCATCCGATTGCGCACAGGTTTCCTGGAG
CAGGGGCTGCTGGTCAAAGATACCAAGAAACTGCGAGACAACTACATCCACACCCTGCAG
TTCAAGCTGGATGTGGCTTCCATCATCCCCACTGACCTGATCTATTTTGCTGTGGACATC
CACAGCCCTGAGGTGCGCTTCAACCGCCTGCTGCACTTTGCCCGCATGTTTGAGTTCTTT
GACCGGACAGAGACACGCACCAACTACCCTAACATCTTCCGCATCAGCAACCTTGTCCTC
TACATCTTGGTCATCATCCACTGGAATGCCTGCATCTATTATGCCATCTCCAAATCCATA
GGCTTTGGGGTCGACACCTGGGTTTACCCAAACATCACTGACCCTGAGTATGGCTACCTG
GCTAGGGAATACATCTATTGCCTTTACTGGTCCACACTGACTCTCACTACCATTGGGGAG
ACACCACCCCCTGTAAAGGATGAGGAGTACCTATTTGTCATCTTTGACTTCCTGATTGGC
GTCCTCATCTTTGCCACCATCGTGGGAAATGTGGGCTCCATGATCTCCAACATGAATGCC
ACCCGGGCAGAGTTCCAGGCTAAGATCGATGCCGTGAAACACTACATGCAGTTCCGAAAG
GTCAGCAAGGGGATGGAAGCCAAGGTCATTAGGTGGTTTGACTACTTGTGGACCAATAAG
AAGACAGTGGATGAGCGAGAAATTCTCAAGAATCTGCCAGCCAAGCTCAGGGCTGAGATA
GCCATCAATGTCCACTTGTCCACACTCAAGAAAGTGCGCATCTTCCATGATTGTGAGGCT
GGCCTGCTGGTAGAGCTGGTACTGAAACTCCGTCCTCAGGTCTTCAGTCCTGGGGATTAC
ATTTGCCGCAAAGGGGACATCGGCAAGGAGATGTACATCATTAAGGAGGGCAAACTGGCA
GTGGTGGCTGATGATGGTGTGACTCAGTATGCTCTGCTGTCGGCTGGAAGCTGCTTTGGC
GAGATCAGTATCCTTAACATTAAGGGCAGTAAAATGGGCAATCGACGCACAGCTAATATC
CGCAGCCTGGGCTACTCAGATCTCTTCTGCTTGTCCAAGGATGATCTTATGGAAGCTGTG
ACTGAGTACCCTGATGCCAAGAAAGTCCTAGAAGAGAGGGGTCGGGAGATCCTCATGAAG
GAGGGACTGCTGGATGAGAACGAAGTGGCAACCAGCATGGAGGTCGACGTGCAGGAGAAG
CTAGGGCAGCTGGAGACCAACATGGAAACCTTGTACACTCGCTTTGGCCGCCTGCTGGCT
GAGTACACGGGGGCCCAGCAGAAGCTCAAGCAGCGCATCACAGTTCTGGAAACCAAGATG
AAACAGAACAATGAAGATGACTACCTGTCTGATGGGATGAACAGCCCTGAGCTGGCTGCT
GCTGACGAGCCATAA

Protein Properties

Number of Residues

664

Molecular Weight

76047.5

Theoretical pI

6.14

Pfam Domain Function

cNMP_binding (PF00027 )
Ion_trans (PF00520 )

Signals

["None"]

Transmembrane Regions

["139-159", "172-192", "225-245", "275-295", "351-371", "454-474"]

Protein Sequence

>Cyclic nucleotide-gated olfactory channel
MTEKTNGVKSSPANNHNHHAPPAIKANGKDDHRTSSRPHSAADDDTSSELQRLADVDAPQ
QGRSGFRRIVRLVGIIREWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDGKGDKDGE
DKGTKKKFELFVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDY
VSDVVYIADLFIRLRTGFLEQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDI
HSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISKSI
GFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIG
VLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNK
KTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDY
ICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANI
RSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDENEVATSMEVDVQEK
LGQLETNMETLYTRFGRLLAEYTGAQQKLKQRITVLETKMKQNNEDDYLSDGMNSPELAA
ADEP

External Links

GenBank ID Protein

116496687

UniProtKB/Swiss-Prot ID

Q16280

UniProtKB/Swiss-Prot Entry Name

CNGA2_HUMAN

PDB IDs

Not Available

GenBank Gene ID

BC126302

GeneCard ID