| Identification |
|---|
| HMDB Protein ID
| CDBP03329 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cyclic AMP-dependent transcription factor ATF-5 |
| Description
| Not Available |
| Synonyms
|
- Activating transcription factor 5
- Transcription factor ATFx
- cAMP-dependent transcription factor ATF-5
|
| Gene Name
| ATF5 |
| Protein Type
| Transcription Factor |
| Biological Properties |
|---|
| General Function
| Involved in sequence-specific DNA binding transcription factor activity |
| Specific Function
| Transcriptional activator which binds the cAMP response element (CRE) (consensus:5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4 |
| GO Classification
|
| Function |
| nucleic acid binding |
| dna binding |
| protein dimerization activity |
| sequence-specific dna binding |
| sequence-specific dna binding transcription factor activity |
| binding |
| protein binding |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of metabolic process |
| regulation of macromolecule metabolic process |
| regulation of gene expression |
| regulation of transcription |
| regulation of transcription, dna-dependent |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19q13.3 |
| SNPs
| ATF5 |
| Gene Sequence
|
>849 bp
ATGTCACTCCTGGCGACCCTGGGGCTGGAGCTGGACAGGGCCCTGCTCCCAGCTAGTGGG
CTGGGATGGCTCGTAGACTATGGGAAACTCCCCCCGGCCCCTGCCCCCCTGGCTCCCTAT
GAGGTCCTTGGGGGAGCCCTGGAGGGCGGGCTTCCAGTGGGGGGAGAGCCCCTGGCAGGT
GATGGCTTCTCTGACTGGATGACTGAGCGAGTTGATTTCACAGCTCTCCTCCCTCTGGAG
CCTCCCCTACCCCCCGGCACCCTCCCCCAACCTTCCCCAACCCCACCTGACCTGGAAGCT
ATGGCCTCCCTCCTCAAGAAGGAGCTGGAACAGATGGAAGACTTCTTCCTAGATGCCCCG
CCCCTCCCACCACCCTCCCCGCCGCCACTACCACCACCACCACTACCACCAGCCCCCTCC
CTCCCCCTGTCCCTCCCCTCCTTTGACCTCCCCCAGCCCCCTGTCTTGGATACTCTGGAC
TTGCTGGCCATCTACTGCCGCAACGAGGCCGGGCAGGAGGAAGTGGGGATGCCGCCTCTG
CCCCCGCCACAGCAGCCCCCTCCTCCTTCTCCACCTCAACCTTCTCGCCTGGCCCCCTAC
CCACATCCTGCCACCACCCGAGGGGACCGCAAGCAAAAGAAGAGAGACCAGAACAAGTCG
GCGGCTCTGAGGTACCGCCAGCGGAAGCGGGCAGAGGGTGAGGCCCTGGAGGGCGAGTGC
CAGGGGCTGGAGGCACGGAATCGCGAGCTGAAGGAACGGGCAGAGTCCGTGGAGCGCGAG
ATCCAGTACGTCAAGGACCTGCTCATCGAGGTTTACAAGGCCCGGAGCCAGAGGACCCGT
AGCTGCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 282 |
| Molecular Weight
| 30673.9 |
| Theoretical pI
| 4.61 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cyclic AMP-dependent transcription factor ATF-5
MSLLATLGLELDRALLPASGLGWLVDYGKLPPAPAPLAPYEVLGGALEGGLPVGGEPLAG
DGFSDWMTERVDFTALLPLEPPLPPGTLPQPSPTPPDLEAMASLLKKELEQMEDFFLDAP
PLPPPSPPPLPPPPLPPAPSLPLSLPSFDLPQPPVLDTLDLLAIYCRNEAGQEEVGMPPL
PPPQQPPPPSPPQPSRLAPYPHPATTRGDRKQKKRDQNKSAALRYRQRKRAEGEALEGEC
QGLEARNRELKERAESVEREIQYVKDLLIEVYKARSQRTRSC
|
| External Links |
|---|
| GenBank ID Protein
| 12583650 |
| UniProtKB/Swiss-Prot ID
| Q9Y2D1 |
| UniProtKB/Swiss-Prot Entry Name
| ATF5_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB021663 |
| GeneCard ID
| ATF5 |
| GenAtlas ID
| ATF5 |
| HGNC ID
| HGNC:790 |
| References |
|---|
| General References
| Not Available |