Showing Protein Cyclic AMP-dependent transcription factor ATF-3 (CDBP03327)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 compounds
Identification
HMDB Protein ID CDBP03327
Secondary Accession Numbers Not Available
Name Cyclic AMP-dependent transcription factor ATF-3
Description Not Available
Synonyms
  1. Activating transcription factor 3
  2. cAMP-dependent transcription factor ATF-3
Gene Name ATF3
Protein Type Transcription Factor
Biological Properties
General Function Involved in sequence-specific DNA binding transcription factor activity
Specific Function This protein binds the cAMP response element (CRE) (consensus:5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters
GO Classification
Component
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
nucleus
Function
binding
protein binding
nucleic acid binding
dna binding
protein dimerization activity
sequence-specific dna binding
sequence-specific dna binding transcription factor activity
Process
regulation of macromolecule metabolic process
regulation of gene expression
regulation of transcription
regulation of transcription, dna-dependent
biological regulation
regulation of biological process
regulation of metabolic process
Cellular Location
  1. Nucleus
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 1q32.3
SNPs ATF3
Gene Sequence 
>546 bp
ATGATGCTTCAACACCCAGGCCAGGTCTCTGCCTCGGAAGTGAGTGCTTCTGCCATCGTC
CCCTGCCTGTCCCCTCCTGGGTCACTGGTGTTTGAGGATTTTGCTAACCTGACGCCCTTT
GTCAAGGAAGAGCTGAGGTTTGCCATCCAGAACAAGCACCTCTGCCACCGGATGTCCTCT
GCGCTGGAATCAGTCACTGTCAGCGACAGACCCCTCGGGGTGTCCATCACAAAAGCCGAG
GTAGCCCCTGAAGAAGATGAAAGGAAAAAGAGGCGACGAGAAAGAAATAAGATTGCAGCT
GCAAAGTGCCGAAACAAGAAGAAGGAGAAGACGGAGTGCCTGCAGAAAGAGTCGGAGAAG
CTGGAAAGTGTGAATGCTGAACTGAAGGCTCAGATTGAGGAGCTCAAGAACGAGAAGCAG
CATTTGATATACATGCTCAACCTTCATCGGCCCACGTGTATTGTCCGGGCTCAGAATGGG
AGGACTCCAGAAGATGAGAGAAACCTCTTTATCCAACAGATAAAAGAAGGAACATTGCAG
AGCTAA
Protein Properties
Number of Residues 181
Molecular Weight 20575.4
Theoretical pI 8.76
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Cyclic AMP-dependent transcription factor ATF-3
MMLQHPGQVSASEVSASAIVPCLSPPGSLVFEDFANLTPFVKEELRFAIQNKHLCHRMSS
ALESVTVSDRPLGVSITKAEVAPEEDERKKRRRERNKIAAAKCRNKKKEKTECLQKESEK
LESVNAELKAQIEELKNEKQHLIYMLNLHRPTCIVRAQNGRTPEDERNLFIQQIKEGTLQ
S
GenBank ID Protein 37574508
UniProtKB/Swiss-Prot ID P18847
UniProtKB/Swiss-Prot Entry Name ATF3_HUMAN
PDB IDs Not Available
GenBank Gene ID AY426987
GeneCard ID ATF3
GenAtlas ID ATF3
HGNC ID HGNC:785
References
General References Not Available