| Identification |
|---|
| HMDB Protein ID
| CDBP03325 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cyclic AMP-dependent transcription factor ATF-1 |
| Description
| Not Available |
| Synonyms
|
- Activating transcription factor 1
- Protein TREB36
- cAMP-dependent transcription factor ATF-1
|
| Gene Name
| ATF1 |
| Protein Type
| Transcription Factor |
| Biological Properties |
|---|
| General Function
| Involved in sequence-specific DNA binding transcription factor activity |
| Specific Function
| This protein binds the cAMP response element (CRE) (consensus:5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes |
| GO Classification
|
| Component |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| nucleus |
| Function |
| binding |
| protein binding |
| nucleic acid binding |
| dna binding |
| protein dimerization activity |
| sequence-specific dna binding |
| sequence-specific dna binding transcription factor activity |
| Process |
| regulation of transcription |
| regulation of transcription, dna-dependent |
| biological regulation |
| regulation of biological process |
| regulation of metabolic process |
| regulation of macromolecule metabolic process |
| regulation of gene expression |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12q13 |
| SNPs
| ATF1 |
| Gene Sequence
|
>816 bp
ATGGAAGATTCCCACAAGAGTACCACGTCAGAGACAGCACCTCAACCTGGTTCAGCAGTT
CAGGGAGCTCACATTTCTCATATTGCTCAACAGGTATCATCTTTATCAGAAAGTGAGGAG
TCCCAGGACTCATCCGACAGCATAGGCTCCTCACAGAAAGCCCACGGGATCCTAGCACGG
CGCCCATCTTACAGAAAAATTTTGAAAGACTTATCTTCTGAAGATACACGGGGCAGAAAA
GGAGACGGAGAAAATTCTGGAGTTTCTGCTGCTGTCACTTCTATGTCTGTTCCAACTCCC
ATCTATCAGACTAGCAGCGGACAGTATATTGCCATTGCCCCAAATGGAGCCTTACAGTTG
GCAAGTCCAGGCACAGATGGAGTACAGGGACTTCAGACATTAACCATGACAAATTCAGGC
AGTACTCAGCAAGGTACAACTATTCTTCAGTATGCACAGACCTCTGATGGACAGCAGATA
CTTGTGCCCAGCAATCAGGTGGTCGTACAAACTGCATCAGGAGATATGCAAACATATCAG
ATCCGAACTACACCTTCAGCTACTTCTCTGCCACAAACTGTGGTGATGACATCTCCTGTG
ACTCTCACCTCTCAGACAACTAAGACAGATGACCCCCAATTGAAAAGAGAAATAAGGTTA
ATGAAAAACAGAGAAGCTGCTCGAGAATGTCGCAGAAAGAAGAAAGAATATGTGAAATGC
CTGGAAAACCGAGTTGCAGTCCTGGAAAATCAAAATAAAACTCTAATAGAAGAGTTAAAA
ACTTTGAAGGATCTTTATTCCAATAAAAGTGTTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 271 |
| Molecular Weight
| 29232.4 |
| Theoretical pI
| 8.64 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cyclic AMP-dependent transcription factor ATF-1
MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILAR
RPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQL
ASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQ
IRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKC
LENRVAVLENQNKTLIEELKTLKDLYSNKSV
|
| External Links |
|---|
| GenBank ID Protein
| 20810445 |
| UniProtKB/Swiss-Prot ID
| P18846 |
| UniProtKB/Swiss-Prot Entry Name
| ATF1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC029619 |
| GeneCard ID
| ATF1 |
| GenAtlas ID
| ATF1 |
| HGNC ID
| HGNC:783 |
| References |
|---|
| General References
| Not Available |