Showing Protein Vesicle-associated membrane protein 7 (CDBP03313)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP03313
Secondary Accession Numbers Not Available
Name Vesicle-associated membrane protein 7
Description Not Available
Synonyms
  1. Synaptobrevin-like protein 1
  2. Tetanus-insensitive VAMP
  3. Ti-VAMP
  4. VAMP-7
Gene Name VAMP7
Protein Type Enzyme
Biological Properties
General Function Involved in vesicle-mediated transport
Specific Function Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation
GO Classification
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Process
establishment of localization
transport
vesicle-mediated transport
Cellular Location
  1. Cytoplasmic vesicle
  2. Cytoplasmic vesicle
  3. Endoplasmic reticulum membrane
  4. Late endosome membrane
  5. Golgi apparatus
  6. Lysosome membrane
  7. Single-pass type IV membrane protein
  8. Single-pass type IV membrane protein
  9. Single-pass type IV membrane protein
  10. Single-pass type IV membrane protein
  11. Single-pass type IV membrane protein
  12. trans-Golgi network membrane
  13. secretory vesicle membrane
  14. Single- pass type IV membrane protein
  15. phagosome membrane
Pathways
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs VAMP7
Gene Sequence 
>663 bp
ATGGCGATTCTTTTTGCTGTTGTTGCCAGGGGGACCACTATCCTTGCCAAACATGCTTGG
TGTGGAGGAAACTTCCTGGAGGTGACAGAGCAGATTCTGGCTAAGATACCTTCTGAAAAT
AACAAACTAACGTACTCACATGGCAATTATTTGTTTCATTACATCTGCCAAGACAGGATT
GTATATCTTTGTATCACTGATGATGATTTTGAACGTTCCCGAGCCTTTAATTTTCTGAAT
GAGATAAAGAAGAGGTTCCAGACTACTTACGGTTCAAGAGCACAGACAGCACTTCCATAT
GCCATGAATAGCGAGTTCTCAAGTGTCTTAGCTGCACAGCTGAAGCATCACTCTGAGAAT
AAGGGCCTAGACAAAGTGATGGAGACTCAAGCCCAAGTGGATGAACTGAAAGGAATCATG
GTCAGAAACATAGATCTGGTAGCTCAGCGAGGAGAAAGATTGGAATTATTGATTGACAAA
ACAGAAAATCTTGTGGATTCTTCTGTCACCTTCAAAACTACCAGCAGAAATCTTGCTCGA
GCCATGTGTATGAAGAACCTCAAGCTCACTATTATCATCATCATCGTATCAATTGTGTTC
ATCTATATCATTGTTTCACCTCTCTGTGGTGGATTTACATGGCCAAGCTGTGTGAAGAAA
TAG
Protein Properties
Number of Residues 220
Molecular Weight 24934.8
Theoretical pI 8.79
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["189-209"]
Protein Sequence 
>Vesicle-associated membrane protein 7
MAILFAVVARGTTILAKHAWCGGNFLEVTEQILAKIPSENNKLTYSHGNYLFHYICQDRI
VYLCITDDDFERSRAFNFLNEIKKRFQTTYGSRAQTALPYAMNSEFSSVLAAQLKHHSEN
KGLDKVMETQAQVDELKGIMVRNIDLVAQRGERLELLIDKTENLVDSSVTFKTTSRNLAR
AMCMKNLKLTIIIIIVSIVFIYIIVSPLCGGFTWPSCVKK
GenBank ID Protein 8979792
UniProtKB/Swiss-Prot ID P51809
UniProtKB/Swiss-Prot Entry Name VAMP7_HUMAN
PDB IDs Not Available
GenBank Gene ID AJ271736
GeneCard ID VAMP7
GenAtlas ID VAMP7
HGNC ID HGNC:11486
References
General References Not Available