Identification |
HMDB Protein ID
| CDBP03310 |
Secondary Accession Numbers
| Not Available |
Name
| Protein unc-13 homolog C |
Description
| Not Available |
Synonyms
|
- Munc13-3
|
Gene Name
| UNC13C |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in intracellular signaling pathway |
Specific Function
| Probably plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Probably is involved in neurotransmitter release |
GO Classification
|
Process |
intracellular signaling pathway |
signaling |
signaling pathway |
|
Cellular Location
|
- Cytoplasm
- Peripheral membrane protein
- Peripheral membrane protein
- Membrane
- Cell junction
- synapse
- presynaptic cell membrane
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 15q21.3 |
SNPs
| UNC13C |
Gene Sequence
|
>6645 bp
ATGGTGGCTAATTTTTTCAAGAGCTTGATTTTACCTTACATTCATAAGCTTTGCAAAGGA
ATGTTTACAAAGAAATTGGGAAATACAAACAAAAACAAAGAGTATCGTCAGCAGAAAAAG
GATCAAGACTTCCCCACTGCTGGCCAGACCAAATCCCCCAAATTTTCTTACACTTTTAAA
AGCACTGTAAAGAAGATTGCAAAGTGTTCATCCACTCACAACTTATCCACTGAGGAAGAC
GAGGCCAGTAAAGAGTTTTCCCTCTCACCAACATTCAGTTACCGAGTAGCTATTGCCAAT
GGCCTACAAAAGAATGCTAAAGTAACCAACAGTGATAATGAGGATCTGCTTCAAGAGCTC
TCTTCAATCGAGAGTTCCTACTCAGAATCATTAAATGAACTAAGGAGTAGCACAGAAAAC
CAGGCACAATCAACACACACAATGCCAGTTAGACGCAACAGAAAGAGTTCAAGCAGCCTT
GCACCCTCTGAGGGCAGCTCTGACGGGGAGCGTACTCTACATGGCTTAAAACTGGGAGCT
TTACGAAAACTGAGAAAATGGAAAAAGAGTCAAGAATGTGTCTCCTCAGACTCAGAGTTA
AGCACCATGAAAAAATCCTGGGGAATAAGAAGTAAGTCTTTGGACAGAACTGTCCGAAAC
CCAAAGACAAATGCCCTGGAGCCAGGGTTCAGTTCCTCTGGCTGCATTAGCCAAACACAT
GATGTCATGGAAATGATCTTTAAGGAACTTCAGGGAATAAGTCAGATTGAAACAGAACTT
TCTGAACTACGAGGGCACGTCAATGCTCTCAAGCACTCCATCGATGAGATCTCCAGCAGT
GTGGAGGTTGTACAAAGTGAAATTGAGCAGTTGCGCACAGGGTTTGTCCAGTCTCGGAGG
GAAACTAGAGACATCCATGATTATATTAAGCACTTAGGTCATATGGGTAGCAAGGCAAGC
CTGAGATTTTTAAATGTGACTGAAGAAAGATTTGAATATGTTGAAAGCGTGGTGTACCAA
ATTCTAATAGATAAAATGGGTTTTTCAGATGCACCAAATGCTATTAAAATTGAATTTGCT
CAGAGGATAGGACACCAGAGAGACTGCCCAAATGCAAAGCCTCGACCCATACTTGTGTAC
TTTGAAACCCCTCAACAAAGGGATTCTGTCTTAAAAAAGTCATATAAACTCAAAGGAACA
GGCATTGGAATCTCAACAGATATTCTAACTCATGACATCAGAGAAAGAAAAGAGAAAGGG
ATACCATCCTCCCAGACATATGAGAGCATGGCTATAAAGTTGTCTACTCCAGAGCCAAAA
ATCAAGAAGAACAATTGGCAGTCACCTGATGACAGTGATGAAGATCTTGAATCTGACCTC
AATAGAAACAGTTACGCTGTGCTTTCCAAGTCAGAGCTTCTAACAAAGGGAAGTACTTCC
AAGCCAAGCTCAAAATCACACAGTGCTAGATCCAAGAATAAAACTGCTAATAGCAGCAGA
ATTTCAAATAAATCAGATTATGATAAAATCTCCTCACAGTTGCCAGAATCAGATATCTTG
GAAAAGCAAACCACAACCCATTATGCAGATGCAACACCTCTCTGGCACTCACAGAGTGAT
TTTTTCACTGCTAAACTTAGTCGTTCTGAATCAGATTTTTCCAAATTGTGTCAGTCTTAC
TCAGAAGATTTTTCAGAAAATCAGTTTTTCACTAGAACTAATGGAAGCTCTCTCCTGTCA
TCTTCGGACCGGGAGCTATGGCAGAGGAAACAGGAAGGAACAGCGACCCTGTATGACAGT
CCCAAGGACCAGCATTTGAATGGAGGTGTTCAGGGTATCCAAGGGCAGACTGAAACTGAA
AACACAGAAACTGTGGATAGTGGAATGAGTAATGGCATGGTGTGTGCATCTGGAGACCGG
AGTCATTACAGTGATTCTCAGCTCTCTTTACATGAGGATCTTTCTCCATGGAAGGAATGG
AATCAAGGAGCTGATTTAGGCTTGGATTCATCCACCCAGGAAGGTTTTGATTATGAAACA
AACAGTCTTTTTGACCAACAGCTTGATGTTTACAATAAAGACCTAGAATACTTGGGAAAG
TGCCACAGTGATCTTCAAGATGACTCAGAGAGCTACGACTTAACTCAAGATGACAATTCT
TCTCCATGCCCTGGCTTGGATAATGAACCACAAGGCCAGTGGGTTGGCCAATATGATTCT
TATCAGGGAGCTAATTCTAATGAGCTATACCAAAATCAAAACCAGTTGTCCATGATGTAT
CGAAGTCAAAGTGAATTGCAAAGTGATGATTCAGAGGATGCCCCACCCAAATCATGGCAT
AGTCGATTAAGCATTGACCTTTCTGATAAGACTTTCAGCTTCCCAAAATTTGGATCTACA
CTGCAGAGGGCTAAATCAGCCTTGGAAGTAGTATGGAACAAAAGCACACAGAGTCTGAGT
GGGTATGAGGACAGTGGCTCTTCATTAATGGGGAGATTTCGGACATTATCTCAATCAACT
GCAAATGAGTCAAGTACCACACTTGACTCTGATGTCTACACGGAGCCCTATTACTATAAA
GCAGAGGATGAGGAAGATTATACTGAACCAGTGGCTGACAATGAAACAGATTATGTTGAA
GTCATGGAACAAGTCCTTGCTAAACTAGAAAACAGGACTAGTATTACTGAAACAGATGAA
CAAATGCAAGCATATGATCACCTTTCATATGAAACACCTTATGAAACCCCACAAGATGAG
GGTTATGATGGTCCAGCAGATGATATGGTTAGTGAAGAGGGGTTAGAACCCTTAAATGAA
ACATCAGCTGAGATGGAAATAAGAGAAGATGAAAACCAAAACATTCCTGAACAGCCAGTG
GAGATCACAAAGCCAAAGAGAATTCGTCCTTCTTTCAAAGAAGCAGCTTTAAGGGCCTAT
AAAAAGCAAATGGCAGAGTTGGAAGAGAAGATCTTGGCTGGAGATAGCAGTTCTGTGGAT
GAAAAGGCTCGAATAGTAAGTGGCAATGATTTGGATGCTTCCAAATTTTCTGCACTCCAG
GTGTGTGGTGGGGCTGGAGGTGGACTTTATGGTATTGACAGCATGCCGGATCTTCGCAGA
AAAAAAACTTTGCCTATTGTCCGAGATGTGGCCATGACCCTGGCTGCCCGGAAATCTGGA
CTCTCCCTGGCTATGGTGATTAGGACATCCCTAAATAATGAGGAACTGAAAATGCACGTC
TTCAAGAAGACCTTGCAGGCACTGATCTACCCTATGTCTTCTACCATCCCACACAATTTT
GAGGTCTGGACGGCTACCACACCCACCTACTGTTATGAGTGTGAAGGGCTCCTGTGGGGC
ATTGCAAGGCAAGGCATGAAGTGTCTGGAGTGTGGAGTGAAATGCCACGAAAAGTGTCAG
GACCTGCTAAACGCTGACTGCTTGCAGAGAGCAGCAGAAAAGAGTTCTAAACATGGTGCC
GAAGACAAGACTCAGACCATTATTACAGCAATGAAAGAAAGAATGAAGATCAGGGAGAAA
AACCGGCCAGAAGTATTTGAAGTAATCCAGGAAATGTTTCAGATTTCTAAAGAAGATTTT
GTGCAGTTTACAAAGGCGGCCAAACAGAGTGTACTGGATGGGACATCTAAGTGGTCTGCA
AAAATAACCATTACAGTGGTTTCTGCACAGGGTCTACAGGCAAAAGATAAAACAGGGTCT
AGTGATCCATATGTTACAGTTCAAGTTGGAAAGAACAAAAGAAGAACAAAAACCATTTTT
GGAAATTTGAATCCAGTATGGGATGAGAAGTTTTATTTTGAGTGTCATAACTCCACAGAT
CGAATCAAAGTCAGAGTATGGGATGAAGATGATGATATTAAATCCAGAGTCAAGCAACAT
TTCAAAAAGGAGTCAGATGATTTTCTGGGACAAACAATTGTAGAAGTGAGGACCTTGAGT
GGAGAAATGGATGTCTGGTACAACTTAGAGAAAAGGACAGATAAGTCAGCTGTATCTGGG
GCCATACGATTGAAAATCAATGTGGAGATAAAAGGAGAAGAGAAGGTTGCTCCATATCAT
ATTCAATATACATGTTTACATGAGAATCTGTTCCATTACTTGACTGAAGTGAAATCTAAT
GGTGGAGTGAAAATCCCAGAAGTCAAAGGGGATGAAGCCTGGAAGGTTTTCTTTGATGAT
GCTTCCCAAGAAATAGTTGATGAATTTGCTATGCGTTATGGAATTGAATCCATTTATCAA
GCTATGACGCACTTTTCATGTCTGTCTTCTAAATACATGTGCCCCGGTGTCCCTGCCGTC
ATGAGCACCTTGCTGGCTAATATAAATGCTTTTTATGCTCACACAACAGTTTCAACAAAC
ATACAGGTTTCTGCCTCAGATCGATTTGCTGCTACCAACTTTGGTAGGGAAAAATTCATA
AAACTACTGGACCAGTTACATAACTCTTTGAGGATTGATCTGTCAAAGTATAGGGAAAAC
TTTCCTGCAAGCAATACTGAAAGACTGCAAGACCTGAAATCAACTGTTGACCTGTTAACA
AGTATCACCTTTTTTAGGATGAAGGTTCTGGAGCTGCAAAGCCCCCCAAAAGCGAGCATG
GTGGTGAAGGACTGTGTAAGGGCTTGCCTGGATTCTACATACAAGTATATTTTTGACAAC
TGCCATGAACTCTACTCCCAGCTAACAGACCCGAGTAAGAAACAGGATATTCCTCGTGAA
GATCAGGGACCAACCACCAAGAATTTGGATTTTTGGCCCCAACTTATTACACTGATGGTT
ACTATTATTGATGAGGATAAAACTGCCTACACACCTGTCCTGAATCAGTTTCCTCAAGAG
CTGAACATGGGAAAAATAAGTGCCGAAATTATGTGGACTCTTTTTGCTCTGGATATGAAA
TATGCATTAGAAGAACATGAAAATCAGCGGTTATGCAAGAGCACCGATTATATGAATTTG
CATTTCAAAGTTAAATGGTTTTATAATGAATATGTGCGTGAACTTCCTGCCTTCAAGGAT
GCTGTTCCTGAATACTCCTTGTGGTTTGAACCTTTTGTCATGCAATGGCTAGATGAAAAC
GAAGATGTGTCAATGGAATTCCTTCATGGAGCACTGGGAAGAGACAAAAAAGATGGATTC
CAGCAGACATCTGAGCATGCTCTCTTTTCTTGCTCCGTGGTTGATGTCTTTGCTCAGCTG
AATCAGAGCTTTGAAATTATTAAGAAACTGGAATGCCCTAATCCTGAAGCATTATCTCAC
TTAATGAGAAGATTTGCAAAGACTATCAATAAAGTGCTGCTCCAGTATGCTGCAATTGTA
TCAAGTGATTTCAGTTCACATTGTGATAAGGAAAATGTGCCCTGTATCTTGATGAACAAT
ATTCAACAATTGCGGGTCCAGCTGGAAAAAATGTTTGAATCCATGGGAGGGAAGGAGCTA
GATTCTGAAGCTAGTACTATTCTAAAAGAACTTCAGGTTAAGCTCAGTGGGGTCCTGGAT
GAGCTCAGCGTCACTTATGGTGAAAGTTTCCAGGTTATAATTGAAGAGTGTATAAAACAG
ATGAGTTTCGAACTAAATCAAATGAGAGCAAATGGAAACACCACATCTAATAAGAACAGT
GCAGCAATGGATGCAGAGATTGTGTTAAGATCTCTTATGGATTTTTTGGACAAAACATTA
AGTCTCTCAGCAAAAATCTGTGAGAAAACAGTCCTAAAGCGAGTTTTAAAAGAGTTATGG
AAGCTAGTTCTCAACAAAATAGAAAAACAAATTGTTCTTCCTCCTCTGACAGATCAAACA
GGACCCCAGATGATTTTCATTGCAGCTAAAGATCTTGGACAATTATCCAAACTGAAGGAG
CACATGATTCGAGAGGATGCCAGGGGTCTGACGCCAAGACAATGCGCTATAATGGAGGTA
GTCCTGGCTACCATCAAGCAATACTTTCATGCAGGAGGAAATGGCCTGAAAAAGAATTTC
TTGGAGAAAAGCCCAGATCTTCAGTCTCTGAGATATGCTCTCAGTCTTTATACCCAAACT
ACTGATGCCTTGATAAAGAAATTCATAGATACTCAAACCTCACAGAGTCGTTCCTCCAAA
GATGCCGTGGGTCAGATATCTGTTCATGTGGACATCACTGCCACCCCAGGAACGGGAGAT
CATAAAGTCACTGTAAAAGTGATTGCTATTAATGACCTAAACTGGCAGACCACAGCAATG
TTCCGCCCCTTTGTGGAAGTTTGTATACTGGGACCCAACCTTGGAGACAAGAAGAGAAAA
CAAGGCACAAAAACAAAAAGCAACACATGGTCACCAAAGTACAATGAAACATTTCAGTTC
ATTCTCGGAAAGGAAAATCGACCAGGGGCTTATGAACTTCATCTCTCAGTTAAGGATTAC
TGCTTTGCCAGAGAAGATCGAATTATCGGAATGACAGTCATTCAGCTACAGAACATAGCA
GAAAAGGGAAGCTATGGGGCATGGTATCCTCTTCTGAAAAATATCTCTATGGATGAAACT
GGTTTGACTATCCTTAGAATACTCTCTCAGAGGACCAGTGATGATGTGGCTAAAGAATTT
GTAAGACTTAAATCTGAAACAAGATCTACTGAAGAGAGTGCTTGA
|
Protein Properties |
Number of Residues
| 2214 |
Molecular Weight
| 250909.3 |
Theoretical pI
| 5.71 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Protein unc-13 homolog C
MVANFFKSLILPYIHKLCKGMFTKKLGNTNKNKEYRQQKKDQDFPTAGQTKSPKFSYTFK
STVKKIAKCSSTHNLSTEEDEASKEFSLSPTFSYRVAIANGLQKNAKVTNSDNEDLLQEL
SSIESSYSESLNELRSSTENQAQSTHTMPVRRNRKSSSSLAPSEGSSDGERTLHGLKLGA
LRKLRKWKKSQECVSSDSELSTMKKSWGIRSKSLDRTVRNPKTNALEPGFSSSGCISQTH
DVMEMIFKELQGISQIETELSELRGHVNALKHSIDEISSSVEVVQSEIEQLRTGFVQSRR
ETRDIHDYIKHLGHMGSKASLRFLNVTEERFEYVESVVYQILIDKMGFSDAPNAIKIEFA
QRIGHQRDCPNAKPRPILVYFETPQQRDSVLKKSYKLKGTGIGISTDILTHDIRERKEKG
IPSSQTYESMAIKLSTPEPKIKKNNWQSPDDSDEDLESDLNRNSYAVLSKSELLTKGSTS
KPSSKSHSARSKNKTANSSRISNKSDYDKISSQLPESDILEKQTTTHYADATPLWHSQSD
FFTAKLSRSESDFSKLCQSYSEDFSENQFFTRTNGSSLLSSSDRELWQRKQEGTATLYDS
PKDQHLNGGVQGIQGQTETENTETVDSGMSNGMVCASGDRSHYSDSQLSLHEDLSPWKEW
NQGADLGLDSSTQEGFDYETNSLFDQQLDVYNKDLEYLGKCHSDLQDDSESYDLTQDDNS
SPCPGLDNEPQGQWVGQYDSYQGANSNELYQNQNQLSMMYRSQSELQSDDSEDAPPKSWH
SRLSIDLSDKTFSFPKFGSTLQRAKSALEVVWNKSTQSLSGYEDSGSSLMGRFRTLSQST
ANESSTTLDSDVYTEPYYYKAEDEEDYTEPVADNETDYVEVMEQVLAKLENRTSITETDE
QMQAYDHLSYETPYETPQDEGYDGPADDMVSEEGLEPLNETSAEMEIREDENQNIPEQPV
EITKPKRIRPSFKEAALRAYKKQMAELEEKILAGDSSSVDEKARIVSGNDLDASKFSALQ
VCGGAGGGLYGIDSMPDLRRKKTLPIVRDVAMTLAARKSGLSLAMVIRTSLNNEELKMHV
FKKTLQALIYPMSSTIPHNFEVWTATTPTYCYECEGLLWGIARQGMKCLECGVKCHEKCQ
DLLNADCLQRAAEKSSKHGAEDKTQTIITAMKERMKIREKNRPEVFEVIQEMFQISKEDF
VQFTKAAKQSVLDGTSKWSAKITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIF
GNLNPVWDEKFYFECHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLS
GEMDVWYNLEKRTDKSAVSGAIRLKINVEIKGEEKVAPYHIQYTCLHENLFHYLTEVKSN
GGVKIPEVKGDEAWKVFFDDASQEIVDEFAMRYGIESIYQAMTHFSCLSSKYMCPGVPAV
MSTLLANINAFYAHTTVSTNIQVSASDRFAATNFGREKFIKLLDQLHNSLRIDLSKYREN
FPASNTERLQDLKSTVDLLTSITFFRMKVLELQSPPKASMVVKDCVRACLDSTYKYIFDN
CHELYSQLTDPSKKQDIPREDQGPTTKNLDFWPQLITLMVTIIDEDKTAYTPVLNQFPQE
LNMGKISAEIMWTLFALDMKYALEEHENQRLCKSTDYMNLHFKVKWFYNEYVRELPAFKD
AVPEYSLWFEPFVMQWLDENEDVSMEFLHGALGRDKKDGFQQTSEHALFSCSVVDVFAQL
NQSFEIIKKLECPNPEALSHLMRRFAKTINKVLLQYAAIVSSDFSSHCDKENVPCILMNN
IQQLRVQLEKMFESMGGKELDSEASTILKELQVKLSGVLDELSVTYGESFQVIIEECIKQ
MSFELNQMRANGNTTSNKNSAAMDAEIVLRSLMDFLDKTLSLSAKICEKTVLKRVLKELW
KLVLNKIEKQIVLPPLTDQTGPQMIFIAAKDLGQLSKLKEHMIREDARGLTPRQCAIMEV
VLATIKQYFHAGGNGLKKNFLEKSPDLQSLRYALSLYTQTTDALIKKFIDTQTSQSRSSK
DAVGQISVHVDITATPGTGDHKVTVKVIAINDLNWQTTAMFRPFVEVCILGPNLGDKKRK
QGTKTKSNTWSPKYNETFQFILGKENRPGAYELHLSVKDYCFAREDRIIGMTVIQLQNIA
EKGSYGAWYPLLKNISMDETGLTILRILSQRTSDDVAKEFVRLKSETRSTEESA
|
External Links |
GenBank ID Protein
| 122937514 |
UniProtKB/Swiss-Prot ID
| Q8NB66 |
UniProtKB/Swiss-Prot Entry Name
| UN13C_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| NM_001080534.1 |
GeneCard ID
| UNC13C |
GenAtlas ID
| UNC13C |
HGNC ID
| HGNC:23149 |
References |
General References
| Not Available |