Identification
HMDB Protein ID CDBP03310
Secondary Accession Numbers Not Available
Name Protein unc-13 homolog C
Description Not Available
Synonyms
  1. Munc13-3
Gene Name UNC13C
Protein Type Enzyme
Biological Properties
General Function Involved in intracellular signaling pathway
Specific Function Probably plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Probably is involved in neurotransmitter release
GO Classification
Process
intracellular signaling pathway
signaling
signaling pathway
Cellular Location
  1. Cytoplasm
  2. Peripheral membrane protein
  3. Peripheral membrane protein
  4. Membrane
  5. Cell junction
  6. synapse
  7. presynaptic cell membrane
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 15q21.3
SNPs UNC13C
Gene Sequence
>6645 bp
ATGGTGGCTAATTTTTTCAAGAGCTTGATTTTACCTTACATTCATAAGCTTTGCAAAGGA
ATGTTTACAAAGAAATTGGGAAATACAAACAAAAACAAAGAGTATCGTCAGCAGAAAAAG
GATCAAGACTTCCCCACTGCTGGCCAGACCAAATCCCCCAAATTTTCTTACACTTTTAAA
AGCACTGTAAAGAAGATTGCAAAGTGTTCATCCACTCACAACTTATCCACTGAGGAAGAC
GAGGCCAGTAAAGAGTTTTCCCTCTCACCAACATTCAGTTACCGAGTAGCTATTGCCAAT
GGCCTACAAAAGAATGCTAAAGTAACCAACAGTGATAATGAGGATCTGCTTCAAGAGCTC
TCTTCAATCGAGAGTTCCTACTCAGAATCATTAAATGAACTAAGGAGTAGCACAGAAAAC
CAGGCACAATCAACACACACAATGCCAGTTAGACGCAACAGAAAGAGTTCAAGCAGCCTT
GCACCCTCTGAGGGCAGCTCTGACGGGGAGCGTACTCTACATGGCTTAAAACTGGGAGCT
TTACGAAAACTGAGAAAATGGAAAAAGAGTCAAGAATGTGTCTCCTCAGACTCAGAGTTA
AGCACCATGAAAAAATCCTGGGGAATAAGAAGTAAGTCTTTGGACAGAACTGTCCGAAAC
CCAAAGACAAATGCCCTGGAGCCAGGGTTCAGTTCCTCTGGCTGCATTAGCCAAACACAT
GATGTCATGGAAATGATCTTTAAGGAACTTCAGGGAATAAGTCAGATTGAAACAGAACTT
TCTGAACTACGAGGGCACGTCAATGCTCTCAAGCACTCCATCGATGAGATCTCCAGCAGT
GTGGAGGTTGTACAAAGTGAAATTGAGCAGTTGCGCACAGGGTTTGTCCAGTCTCGGAGG
GAAACTAGAGACATCCATGATTATATTAAGCACTTAGGTCATATGGGTAGCAAGGCAAGC
CTGAGATTTTTAAATGTGACTGAAGAAAGATTTGAATATGTTGAAAGCGTGGTGTACCAA
ATTCTAATAGATAAAATGGGTTTTTCAGATGCACCAAATGCTATTAAAATTGAATTTGCT
CAGAGGATAGGACACCAGAGAGACTGCCCAAATGCAAAGCCTCGACCCATACTTGTGTAC
TTTGAAACCCCTCAACAAAGGGATTCTGTCTTAAAAAAGTCATATAAACTCAAAGGAACA
GGCATTGGAATCTCAACAGATATTCTAACTCATGACATCAGAGAAAGAAAAGAGAAAGGG
ATACCATCCTCCCAGACATATGAGAGCATGGCTATAAAGTTGTCTACTCCAGAGCCAAAA
ATCAAGAAGAACAATTGGCAGTCACCTGATGACAGTGATGAAGATCTTGAATCTGACCTC
AATAGAAACAGTTACGCTGTGCTTTCCAAGTCAGAGCTTCTAACAAAGGGAAGTACTTCC
AAGCCAAGCTCAAAATCACACAGTGCTAGATCCAAGAATAAAACTGCTAATAGCAGCAGA
ATTTCAAATAAATCAGATTATGATAAAATCTCCTCACAGTTGCCAGAATCAGATATCTTG
GAAAAGCAAACCACAACCCATTATGCAGATGCAACACCTCTCTGGCACTCACAGAGTGAT
TTTTTCACTGCTAAACTTAGTCGTTCTGAATCAGATTTTTCCAAATTGTGTCAGTCTTAC
TCAGAAGATTTTTCAGAAAATCAGTTTTTCACTAGAACTAATGGAAGCTCTCTCCTGTCA
TCTTCGGACCGGGAGCTATGGCAGAGGAAACAGGAAGGAACAGCGACCCTGTATGACAGT
CCCAAGGACCAGCATTTGAATGGAGGTGTTCAGGGTATCCAAGGGCAGACTGAAACTGAA
AACACAGAAACTGTGGATAGTGGAATGAGTAATGGCATGGTGTGTGCATCTGGAGACCGG
AGTCATTACAGTGATTCTCAGCTCTCTTTACATGAGGATCTTTCTCCATGGAAGGAATGG
AATCAAGGAGCTGATTTAGGCTTGGATTCATCCACCCAGGAAGGTTTTGATTATGAAACA
AACAGTCTTTTTGACCAACAGCTTGATGTTTACAATAAAGACCTAGAATACTTGGGAAAG
TGCCACAGTGATCTTCAAGATGACTCAGAGAGCTACGACTTAACTCAAGATGACAATTCT
TCTCCATGCCCTGGCTTGGATAATGAACCACAAGGCCAGTGGGTTGGCCAATATGATTCT
TATCAGGGAGCTAATTCTAATGAGCTATACCAAAATCAAAACCAGTTGTCCATGATGTAT
CGAAGTCAAAGTGAATTGCAAAGTGATGATTCAGAGGATGCCCCACCCAAATCATGGCAT
AGTCGATTAAGCATTGACCTTTCTGATAAGACTTTCAGCTTCCCAAAATTTGGATCTACA
CTGCAGAGGGCTAAATCAGCCTTGGAAGTAGTATGGAACAAAAGCACACAGAGTCTGAGT
GGGTATGAGGACAGTGGCTCTTCATTAATGGGGAGATTTCGGACATTATCTCAATCAACT
GCAAATGAGTCAAGTACCACACTTGACTCTGATGTCTACACGGAGCCCTATTACTATAAA
GCAGAGGATGAGGAAGATTATACTGAACCAGTGGCTGACAATGAAACAGATTATGTTGAA
GTCATGGAACAAGTCCTTGCTAAACTAGAAAACAGGACTAGTATTACTGAAACAGATGAA
CAAATGCAAGCATATGATCACCTTTCATATGAAACACCTTATGAAACCCCACAAGATGAG
GGTTATGATGGTCCAGCAGATGATATGGTTAGTGAAGAGGGGTTAGAACCCTTAAATGAA
ACATCAGCTGAGATGGAAATAAGAGAAGATGAAAACCAAAACATTCCTGAACAGCCAGTG
GAGATCACAAAGCCAAAGAGAATTCGTCCTTCTTTCAAAGAAGCAGCTTTAAGGGCCTAT
AAAAAGCAAATGGCAGAGTTGGAAGAGAAGATCTTGGCTGGAGATAGCAGTTCTGTGGAT
GAAAAGGCTCGAATAGTAAGTGGCAATGATTTGGATGCTTCCAAATTTTCTGCACTCCAG
GTGTGTGGTGGGGCTGGAGGTGGACTTTATGGTATTGACAGCATGCCGGATCTTCGCAGA
AAAAAAACTTTGCCTATTGTCCGAGATGTGGCCATGACCCTGGCTGCCCGGAAATCTGGA
CTCTCCCTGGCTATGGTGATTAGGACATCCCTAAATAATGAGGAACTGAAAATGCACGTC
TTCAAGAAGACCTTGCAGGCACTGATCTACCCTATGTCTTCTACCATCCCACACAATTTT
GAGGTCTGGACGGCTACCACACCCACCTACTGTTATGAGTGTGAAGGGCTCCTGTGGGGC
ATTGCAAGGCAAGGCATGAAGTGTCTGGAGTGTGGAGTGAAATGCCACGAAAAGTGTCAG
GACCTGCTAAACGCTGACTGCTTGCAGAGAGCAGCAGAAAAGAGTTCTAAACATGGTGCC
GAAGACAAGACTCAGACCATTATTACAGCAATGAAAGAAAGAATGAAGATCAGGGAGAAA
AACCGGCCAGAAGTATTTGAAGTAATCCAGGAAATGTTTCAGATTTCTAAAGAAGATTTT
GTGCAGTTTACAAAGGCGGCCAAACAGAGTGTACTGGATGGGACATCTAAGTGGTCTGCA
AAAATAACCATTACAGTGGTTTCTGCACAGGGTCTACAGGCAAAAGATAAAACAGGGTCT
AGTGATCCATATGTTACAGTTCAAGTTGGAAAGAACAAAAGAAGAACAAAAACCATTTTT
GGAAATTTGAATCCAGTATGGGATGAGAAGTTTTATTTTGAGTGTCATAACTCCACAGAT
CGAATCAAAGTCAGAGTATGGGATGAAGATGATGATATTAAATCCAGAGTCAAGCAACAT
TTCAAAAAGGAGTCAGATGATTTTCTGGGACAAACAATTGTAGAAGTGAGGACCTTGAGT
GGAGAAATGGATGTCTGGTACAACTTAGAGAAAAGGACAGATAAGTCAGCTGTATCTGGG
GCCATACGATTGAAAATCAATGTGGAGATAAAAGGAGAAGAGAAGGTTGCTCCATATCAT
ATTCAATATACATGTTTACATGAGAATCTGTTCCATTACTTGACTGAAGTGAAATCTAAT
GGTGGAGTGAAAATCCCAGAAGTCAAAGGGGATGAAGCCTGGAAGGTTTTCTTTGATGAT
GCTTCCCAAGAAATAGTTGATGAATTTGCTATGCGTTATGGAATTGAATCCATTTATCAA
GCTATGACGCACTTTTCATGTCTGTCTTCTAAATACATGTGCCCCGGTGTCCCTGCCGTC
ATGAGCACCTTGCTGGCTAATATAAATGCTTTTTATGCTCACACAACAGTTTCAACAAAC
ATACAGGTTTCTGCCTCAGATCGATTTGCTGCTACCAACTTTGGTAGGGAAAAATTCATA
AAACTACTGGACCAGTTACATAACTCTTTGAGGATTGATCTGTCAAAGTATAGGGAAAAC
TTTCCTGCAAGCAATACTGAAAGACTGCAAGACCTGAAATCAACTGTTGACCTGTTAACA
AGTATCACCTTTTTTAGGATGAAGGTTCTGGAGCTGCAAAGCCCCCCAAAAGCGAGCATG
GTGGTGAAGGACTGTGTAAGGGCTTGCCTGGATTCTACATACAAGTATATTTTTGACAAC
TGCCATGAACTCTACTCCCAGCTAACAGACCCGAGTAAGAAACAGGATATTCCTCGTGAA
GATCAGGGACCAACCACCAAGAATTTGGATTTTTGGCCCCAACTTATTACACTGATGGTT
ACTATTATTGATGAGGATAAAACTGCCTACACACCTGTCCTGAATCAGTTTCCTCAAGAG
CTGAACATGGGAAAAATAAGTGCCGAAATTATGTGGACTCTTTTTGCTCTGGATATGAAA
TATGCATTAGAAGAACATGAAAATCAGCGGTTATGCAAGAGCACCGATTATATGAATTTG
CATTTCAAAGTTAAATGGTTTTATAATGAATATGTGCGTGAACTTCCTGCCTTCAAGGAT
GCTGTTCCTGAATACTCCTTGTGGTTTGAACCTTTTGTCATGCAATGGCTAGATGAAAAC
GAAGATGTGTCAATGGAATTCCTTCATGGAGCACTGGGAAGAGACAAAAAAGATGGATTC
CAGCAGACATCTGAGCATGCTCTCTTTTCTTGCTCCGTGGTTGATGTCTTTGCTCAGCTG
AATCAGAGCTTTGAAATTATTAAGAAACTGGAATGCCCTAATCCTGAAGCATTATCTCAC
TTAATGAGAAGATTTGCAAAGACTATCAATAAAGTGCTGCTCCAGTATGCTGCAATTGTA
TCAAGTGATTTCAGTTCACATTGTGATAAGGAAAATGTGCCCTGTATCTTGATGAACAAT
ATTCAACAATTGCGGGTCCAGCTGGAAAAAATGTTTGAATCCATGGGAGGGAAGGAGCTA
GATTCTGAAGCTAGTACTATTCTAAAAGAACTTCAGGTTAAGCTCAGTGGGGTCCTGGAT
GAGCTCAGCGTCACTTATGGTGAAAGTTTCCAGGTTATAATTGAAGAGTGTATAAAACAG
ATGAGTTTCGAACTAAATCAAATGAGAGCAAATGGAAACACCACATCTAATAAGAACAGT
GCAGCAATGGATGCAGAGATTGTGTTAAGATCTCTTATGGATTTTTTGGACAAAACATTA
AGTCTCTCAGCAAAAATCTGTGAGAAAACAGTCCTAAAGCGAGTTTTAAAAGAGTTATGG
AAGCTAGTTCTCAACAAAATAGAAAAACAAATTGTTCTTCCTCCTCTGACAGATCAAACA
GGACCCCAGATGATTTTCATTGCAGCTAAAGATCTTGGACAATTATCCAAACTGAAGGAG
CACATGATTCGAGAGGATGCCAGGGGTCTGACGCCAAGACAATGCGCTATAATGGAGGTA
GTCCTGGCTACCATCAAGCAATACTTTCATGCAGGAGGAAATGGCCTGAAAAAGAATTTC
TTGGAGAAAAGCCCAGATCTTCAGTCTCTGAGATATGCTCTCAGTCTTTATACCCAAACT
ACTGATGCCTTGATAAAGAAATTCATAGATACTCAAACCTCACAGAGTCGTTCCTCCAAA
GATGCCGTGGGTCAGATATCTGTTCATGTGGACATCACTGCCACCCCAGGAACGGGAGAT
CATAAAGTCACTGTAAAAGTGATTGCTATTAATGACCTAAACTGGCAGACCACAGCAATG
TTCCGCCCCTTTGTGGAAGTTTGTATACTGGGACCCAACCTTGGAGACAAGAAGAGAAAA
CAAGGCACAAAAACAAAAAGCAACACATGGTCACCAAAGTACAATGAAACATTTCAGTTC
ATTCTCGGAAAGGAAAATCGACCAGGGGCTTATGAACTTCATCTCTCAGTTAAGGATTAC
TGCTTTGCCAGAGAAGATCGAATTATCGGAATGACAGTCATTCAGCTACAGAACATAGCA
GAAAAGGGAAGCTATGGGGCATGGTATCCTCTTCTGAAAAATATCTCTATGGATGAAACT
GGTTTGACTATCCTTAGAATACTCTCTCAGAGGACCAGTGATGATGTGGCTAAAGAATTT
GTAAGACTTAAATCTGAAACAAGATCTACTGAAGAGAGTGCTTGA
Protein Properties
Number of Residues 2214
Molecular Weight 250909.3
Theoretical pI 5.71
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>Protein unc-13 homolog C
MVANFFKSLILPYIHKLCKGMFTKKLGNTNKNKEYRQQKKDQDFPTAGQTKSPKFSYTFK
STVKKIAKCSSTHNLSTEEDEASKEFSLSPTFSYRVAIANGLQKNAKVTNSDNEDLLQEL
SSIESSYSESLNELRSSTENQAQSTHTMPVRRNRKSSSSLAPSEGSSDGERTLHGLKLGA
LRKLRKWKKSQECVSSDSELSTMKKSWGIRSKSLDRTVRNPKTNALEPGFSSSGCISQTH
DVMEMIFKELQGISQIETELSELRGHVNALKHSIDEISSSVEVVQSEIEQLRTGFVQSRR
ETRDIHDYIKHLGHMGSKASLRFLNVTEERFEYVESVVYQILIDKMGFSDAPNAIKIEFA
QRIGHQRDCPNAKPRPILVYFETPQQRDSVLKKSYKLKGTGIGISTDILTHDIRERKEKG
IPSSQTYESMAIKLSTPEPKIKKNNWQSPDDSDEDLESDLNRNSYAVLSKSELLTKGSTS
KPSSKSHSARSKNKTANSSRISNKSDYDKISSQLPESDILEKQTTTHYADATPLWHSQSD
FFTAKLSRSESDFSKLCQSYSEDFSENQFFTRTNGSSLLSSSDRELWQRKQEGTATLYDS
PKDQHLNGGVQGIQGQTETENTETVDSGMSNGMVCASGDRSHYSDSQLSLHEDLSPWKEW
NQGADLGLDSSTQEGFDYETNSLFDQQLDVYNKDLEYLGKCHSDLQDDSESYDLTQDDNS
SPCPGLDNEPQGQWVGQYDSYQGANSNELYQNQNQLSMMYRSQSELQSDDSEDAPPKSWH
SRLSIDLSDKTFSFPKFGSTLQRAKSALEVVWNKSTQSLSGYEDSGSSLMGRFRTLSQST
ANESSTTLDSDVYTEPYYYKAEDEEDYTEPVADNETDYVEVMEQVLAKLENRTSITETDE
QMQAYDHLSYETPYETPQDEGYDGPADDMVSEEGLEPLNETSAEMEIREDENQNIPEQPV
EITKPKRIRPSFKEAALRAYKKQMAELEEKILAGDSSSVDEKARIVSGNDLDASKFSALQ
VCGGAGGGLYGIDSMPDLRRKKTLPIVRDVAMTLAARKSGLSLAMVIRTSLNNEELKMHV
FKKTLQALIYPMSSTIPHNFEVWTATTPTYCYECEGLLWGIARQGMKCLECGVKCHEKCQ
DLLNADCLQRAAEKSSKHGAEDKTQTIITAMKERMKIREKNRPEVFEVIQEMFQISKEDF
VQFTKAAKQSVLDGTSKWSAKITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIF
GNLNPVWDEKFYFECHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLS
GEMDVWYNLEKRTDKSAVSGAIRLKINVEIKGEEKVAPYHIQYTCLHENLFHYLTEVKSN
GGVKIPEVKGDEAWKVFFDDASQEIVDEFAMRYGIESIYQAMTHFSCLSSKYMCPGVPAV
MSTLLANINAFYAHTTVSTNIQVSASDRFAATNFGREKFIKLLDQLHNSLRIDLSKYREN
FPASNTERLQDLKSTVDLLTSITFFRMKVLELQSPPKASMVVKDCVRACLDSTYKYIFDN
CHELYSQLTDPSKKQDIPREDQGPTTKNLDFWPQLITLMVTIIDEDKTAYTPVLNQFPQE
LNMGKISAEIMWTLFALDMKYALEEHENQRLCKSTDYMNLHFKVKWFYNEYVRELPAFKD
AVPEYSLWFEPFVMQWLDENEDVSMEFLHGALGRDKKDGFQQTSEHALFSCSVVDVFAQL
NQSFEIIKKLECPNPEALSHLMRRFAKTINKVLLQYAAIVSSDFSSHCDKENVPCILMNN
IQQLRVQLEKMFESMGGKELDSEASTILKELQVKLSGVLDELSVTYGESFQVIIEECIKQ
MSFELNQMRANGNTTSNKNSAAMDAEIVLRSLMDFLDKTLSLSAKICEKTVLKRVLKELW
KLVLNKIEKQIVLPPLTDQTGPQMIFIAAKDLGQLSKLKEHMIREDARGLTPRQCAIMEV
VLATIKQYFHAGGNGLKKNFLEKSPDLQSLRYALSLYTQTTDALIKKFIDTQTSQSRSSK
DAVGQISVHVDITATPGTGDHKVTVKVIAINDLNWQTTAMFRPFVEVCILGPNLGDKKRK
QGTKTKSNTWSPKYNETFQFILGKENRPGAYELHLSVKDYCFAREDRIIGMTVIQLQNIA
EKGSYGAWYPLLKNISMDETGLTILRILSQRTSDDVAKEFVRLKSETRSTEESA
GenBank ID Protein 122937514
UniProtKB/Swiss-Prot ID Q8NB66
UniProtKB/Swiss-Prot Entry Name UN13C_HUMAN
PDB IDs
GenBank Gene ID NM_001080534.1
GeneCard ID UNC13C
GenAtlas ID UNC13C
HGNC ID HGNC:23149
References
General References Not Available