| Identification |
|---|
| HMDB Protein ID
| CDBP03307 |
| Secondary Accession Numbers
| Not Available |
| Name
| UDP-glucose:glycoprotein glucosyltransferase 1 |
| Description
| Not Available |
| Synonyms
|
- UDP--Glc:glycoprotein glucosyltransferase
- UDP-glucose ceramide glucosyltransferase-like 1
- UGT1
- hUGT1
|
| Gene Name
| UGGT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in UDP-glucose:glycoprotein glucosyltransferase activity |
| Specific Function
| Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation |
| GO Classification
|
| Function |
| catalytic activity |
| transferase activity |
| udp-glycosyltransferase activity |
| transferase activity, transferring glycosyl groups |
| udp-glucosyltransferase activity |
| udp-glucose:glycoprotein glucosyltransferase activity |
| Process |
| metabolic process |
| macromolecule metabolic process |
| macromolecule modification |
| protein modification process |
| protein amino acid glycosylation |
|
| Cellular Location
|
- Endoplasmic reticulum lumen
- Endoplasmic reticulum-Golgi intermediate compartment
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2q14.3 |
| SNPs
| UGGT1 |
| Gene Sequence
|
>4668 bp
ATGGGCTGCAAGGGAGACGCGAGCGGTGCGTGTGCCGCGGGTGCGCTGCCGGTGACAGGA
GTTTGCTATAAAATGGGAGTTCTGGTTGTACTCACTGTTCTGTGGCTGTTCTCCTCAGTA
AAGGCCGACTCAAAAGCCATTACAACCTCTCTTACAACAAAATGGTTTTCCACTCCATTG
TTGTTAGAAGCCAGTGAGTTTTTAGCAGAAGACAGTCAAGAGAAATTTTGGAATTTTGTA
GAAGCCAGTCAAAATATTGGATCATCAGATCATGACGGTACCGATTATTCCTACTATCAT
GCAATATTGGAGGCTGCATTTCAGTTTCTGTCACCCCTCCAGCAGAATTTGTTTAAATTT
TGTCTGTCCCTTCGTTCTTACTCAGCTACAATCCAAGCCTTCCAGCAGATAGCAGCTGAT
GAACCTCCACCAGAAGGATGTAATTCGTTTTTTTCAGTGCATGGAAAGAAGACTTGTGAA
TCTGATACCCTTGAGGCTCTTCTACTGACAGCCTCTGAAAGACCCAAACCTTTATTGTTC
AAAGGAGATCACAGATATCCCTCGTCTAATCCTGAAAGCCCTGTGGTGATTTTCTACTCT
GAGATTGGCTCTGAGGAATTTTCCAATTTTCACCGCCAGCTTATATCAAAAAGCAATGCA
GGCAAAATCAATTATGTATTCAGACATTATATATTTAATCCCAGGAAGGAGCCTGTTTAC
CTCTCTGGCTATGGCGTGGAATTGGCCATTAAGAGCACTGAGTACAAGGCCAAGGATGAT
ACTCAGGTGAAAGGAACTGAGGTAAACACCACAGTGATTGGTGAAAATGATCCTATTGAT
GAGGTTCAGGGGTTCCTCTTTGGAAAATTAAGAGATCTGCACCCCGACCTGGAGGGACAG
TTGAAAGAACTCAGAAAGCATCTTGTAGAGAGCACCAATGAAATGGCACCTTTAAAGGTT
TGGCAGTTGCAAGATCTCAGTTTCCAGACTGCTGCTCGAATCTTGGCTTCTCCTGTTGAG
TTGGCTTTGGTTGTCATGAAGGATCTTAGTCAGAATTTTCCTACCAAAGCCAGAGCAATA
ACAAAAACAGCTGTGAGCTCAGAACTTAGAACCGAAGTGGAAGAGAATCAGAAGTATTTC
AAGGGAACTTTAGGATTACAACCTGGAGATTCAGCCCTCTTCATCAATGGACTTCACATG
GATTTAGATACACAGGATATATTCAGTCTGTTTGATGTGTTGAGGAATGAAGCTCGGGTA
ATGGAGGGTCTGCATAGATTGGGAATAGAAGGCCTTTCTCTGCATAATGTTTTGAAGCTG
AACATCCAGCCCTCTGAGGCAGACTATGCCGTAGACATCCGGAGTCCTGCTATTTCATGG
GTCAACAACCTGGAGGTTGATAGCAGATATAATTCGTGGCCTTCTAGTTTACAAGAGTTG
CTTCGACCCACCTTTCCTGGTGTTATTCGGCAGATCAGGAAAAACTTACATAATATGGTT
TTCATAGTTGATCCTGCACATGAGACCACAGCAGAGTTGATGAACACAGCTGAGATGTTC
CTTAGTAATCATATACCACTAAGAATTGGTTTTATCTTTGTGGTTAATGACTCTGAAGAT
GTTGATGGGATGCAAGATGCTGGAGTGGCTGTTCTTAGAGCATATAATTATGTTGCCCAA
GAAGTGGATGATTATCATGCCTTCCAGACTCTGACACATATCTATAACAAGGTGAGGACT
GGAGAAAAAGTGAAAGTTGAACATGTGGTCAGTGTCCTGGAGAAGAAATATCCGTATGTA
GAAGTGAATAGCATTTTGGGGATTGATTCTGCTTATGATCGGAATCGGAAGGAAGCAAGA
GGCTACTATGAGCAGACTGGAGTTGGACCTCTGCCCGTTGTGCTGTTCAATGGAATGCCC
TTTGAAAGGGAACAGCTAGACCCTGATGAGTTAGAAACCATCACAATGCATAAAATCCTG
GAGACCACCACCTTCTTCCAAAGAGCGGTGTACTTGGGTGAACTGCCCCATGATCAAGAT
GTGGTAGAGTATATCATGAATCAGCCAAATGTTGTTCCACGAATCAATTCTAGGATTTTG
ACAGCTGAACGAGACTACCTGGATTTAACAGCGAGTAATAACTTCTTTGTGGATGATTAT
GCTAGATTTACTATCTTGGATTCCCAAGGCAAGACTGCTGCTGTAGCCAATAGTATGAAC
TATCTGACAAAGAAAGGAATGTCCTCCAAGGAAATCTATGATGATTCTTTTATTAGGCCA
GTAACTTTTTGGATTGTTGGGGATTTTGATAGCCCTTCTGGACGGCAGTTACTGTATGAT
GCCATCAAACATCAGAAATCCAGTAACAATGTTAGAATAAGCATGATCAATAATCCTGCC
AAAGAGATAAGCTATGAGAACACTCAGATCTCCAGAGCAATCTGGGCAGCTCTCCAAACT
CAGACTTCCAACGCTGCTAAGAACTTCATCACCAAAATGGCCAAGGAGGGGGCTGCAGAG
GCCCTGGCTGCAGGAGCTGACATTGCGGAGTTCTCTGTTGGGGGAATGGATTTCAGTCTT
TTTAAAGAGGTCTTTGAGTCTTCCAAAATGGATTTCATTTTGTCTCATGCCGTGTACTGC
AGGGATGTTCTGAAGCTGAAGAAGGGACAGAGGGCAGTGATCAGCAATGGAAGGATCATT
GGGCCACTGGAGGATAGTGAGCTCTTTAATCAAGACGATTTCCACCTCCTCGAAAATATC
ATCTTAAAAACCTCAGGACAGAAAATAAAATCTCATATTCAACAGCTTCGGGTAGAAGAA
GATGTGGCAAGCGACTTGGTAATGAAGGTGGATGCTCTTCTGTCAGCGCAACCAAAAGGA
GATCCAAGAATCGAGTACCAGTTTTTTGAAGACAGACACAGTGCAATCAAACTGAGGCCG
AAGGAAGGGGAGACATACTTTGATGTTGTGGCTGTCGTTGACCCTGTCACCAGAGAAGCA
CAGAGACTTGCTCCTTTGCTCTTGGTTTTGGCTCAGCTGATAAACATGAATCTGAGAGTA
TTTATGAACTGCCAATCCAAACTTTCTGACATGCCTTTAAAAAGCTTTTACCGTTATGTC
TTAGAACCAGAGATTTCTTTCACTTCAGACAATAGTTTTGCTAAGGGTCCAATCGCAAAA
TTTTTGGATATGCCTCAGTCTCCACTGTTCACTCTGAATTTGAACACACCTGAGAGCTGG
ATGGTAGAATCTGTCAGAACACCATATGATCTTGATAATATTTATTTAGAAGAGGTGGAC
AGTGTAGTGGCTGCTGAGTATGAGCTGGAATACCTGTTACTGGAAGGTCATTGCTACGAC
ATCACCACAGGCCAGCCTCCACGGGGACTACAGTTTACCTTAGGAACTTCAGCCAACCCG
GTCATTGTGGACACCATTGTTATGGCCAATCTGGGCTACTTTCAGCTGAAAGCCAACCCA
GGAGCTTGGATCCTCAGACTTAGGAAGGGACGCTCTGAAGATATTTATAGAATTTACAGC
CACGATGGCACTGATTCTCCCCCTGATGCTGATGAGGTGGTTATCGTCCTCAACAACTTC
AAAAGCAAAATTATTAAAGTGAAGGTTCAGAAGAAGGCAGATATGGTGAACGAAGACTTG
CTGAGTGATGGAACGAGTGAGAATGAATCTGGATTTTGGGATTCCTTCAAATGGGGCTTT
ACAGGACAGAAGACTGAGGAAGTGAAGCAAGATAAAGATGACATAATTAATATTTTCTCC
GTTGCATCTGGTCATCTCTACGAAAGATTTCTTCGCATAATGATGCTATCCGTGCTGAAG
AATACCAAGACTCCTGTGAAATTCTGGTTCTTGAAGAATTACTTGTCCCCCACATTTAAG
GAGTTTATACCTTACATGGCAAATGAATACAATTTCCAGTATGAGCTTGTTCAGTACAAA
TGGCCCCGGTGGCTTCATCAACAAACTGAAAAACAGCGTATCATCTGGGGTTACAAGATC
CTCTTCCTGGATGTACTTTTCCCACTAGTTGTTGACAAGTTCCTGTTTGTGGATGCTGAT
CAGATTGTACGAACAGATCTGAAAGAGTTAAGAGATTTCAATTTGGATGGTGCTCCTTAT
GGTTACACTCCTTTCTGTGACAGCCGAAGAGAAATGGACGGCTACAGGTTCTGGAAGTCA
GGGTACTGGGCCAGTCATTTAGCCGGGCGAAAGTATCATATCAGTGCACTATATGTTGTG
GATCTGAAGAAGTTTAGGAAAATAGCTGCTGGTGACAGACTCAGGGGACAGTACCAAGGT
CTGAGTCAGGACCCTAACAGCCTTTCAAATCTTGATCAAGATCTGCCCAATAACATGATT
CATCAGGTGCCAATTAAATCCCTCCCTCAAGAATGGCTTTGGTGTGAAACGTGGTGTGAT
GACGCCTCTAAGAAAAGGGCAAAAACCATTGATTTGTGTAATAATCCGATGACCAAAGAG
CCGAAACTGGAAGCAGCTGTGCGGATTGTCCCGGAGTGGCAGGACTACGACCAAGAGATC
AAACAGCTACAGATCCGCTTTCAGAAGGAGAAAGAAACGGGAGCACTGTACAAAGAGAAG
ACAAAAGAACCAAGCCGAGAAGGTCCTCAGAAACGTGAAGAATTATGA
|
| Protein Properties |
|---|
| Number of Residues
| 1555 |
| Molecular Weight
| 177188.0 |
| Theoretical pI
| 5.32 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>UDP-glucose:glycoprotein glucosyltransferase 1
MGCKGDASGACAAGALPVTGVCYKMGVLVVLTVLWLFSSVKADSKAITTSLTTKWFSTPL
LLEASEFLAEDSQEKFWNFVEASQNIGSSDHDGTDYSYYHAILEAAFQFLSPLQQNLFKF
CLSLRSYSATIQAFQQIAADEPPPEGCNSFFSVHGKKTCESDTLEALLLTASERPKPLLF
KGDHRYPSSNPESPVVIFYSEIGSEEFSNFHRQLISKSNAGKINYVFRHYIFNPRKEPVY
LSGYGVELAIKSTEYKAKDDTQVKGTEVNTTVIGENDPIDEVQGFLFGKLRDLHPDLEGQ
LKELRKHLVESTNEMAPLKVWQLQDLSFQTAARILASPVELALVVMKDLSQNFPTKARAI
TKTAVSSELRTEVEENQKYFKGTLGLQPGDSALFINGLHMDLDTQDIFSLFDVLRNEARV
MEGLHRLGIEGLSLHNVLKLNIQPSEADYAVDIRSPAISWVNNLEVDSRYNSWPSSLQEL
LRPTFPGVIRQIRKNLHNMVFIVDPAHETTAELMNTAEMFLSNHIPLRIGFIFVVNDSED
VDGMQDAGVAVLRAYNYVAQEVDDYHAFQTLTHIYNKVRTGEKVKVEHVVSVLEKKYPYV
EVNSILGIDSAYDRNRKEARGYYEQTGVGPLPVVLFNGMPFEREQLDPDELETITMHKIL
ETTTFFQRAVYLGELPHDQDVVEYIMNQPNVVPRINSRILTAERDYLDLTASNNFFVDDY
ARFTILDSQGKTAAVANSMNYLTKKGMSSKEIYDDSFIRPVTFWIVGDFDSPSGRQLLYD
AIKHQKSSNNVRISMINNPAKEISYENTQISRAIWAALQTQTSNAAKNFITKMAKEGAAE
ALAAGADIAEFSVGGMDFSLFKEVFESSKMDFILSHAVYCRDVLKLKKGQRAVISNGRII
GPLEDSELFNQDDFHLLENIILKTSGQKIKSHIQQLRVEEDVASDLVMKVDALLSAQPKG
DPRIEYQFFEDRHSAIKLRPKEGETYFDVVAVVDPVTREAQRLAPLLLVLAQLINMNLRV
FMNCQSKLSDMPLKSFYRYVLEPEISFTSDNSFAKGPIAKFLDMPQSPLFTLNLNTPESW
MVESVRTPYDLDNIYLEEVDSVVAAEYELEYLLLEGHCYDITTGQPPRGLQFTLGTSANP
VIVDTIVMANLGYFQLKANPGAWILRLRKGRSEDIYRIYSHDGTDSPPDADEVVIVLNNF
KSKIIKVKVQKKADMVNEDLLSDGTSENESGFWDSFKWGFTGQKTEEVKQDKDDIINIFS
VASGHLYERFLRIMMLSVLKNTKTPVKFWFLKNYLSPTFKEFIPYMANEYNFQYELVQYK
WPRWLHQQTEKQRIIWGYKILFLDVLFPLVVDKFLFVDADQIVRTDLKELRDFNLDGAPY
GYTPFCDSRREMDGYRFWKSGYWASHLAGRKYHISALYVVDLKKFRKIAAGDRLRGQYQG
LSQDPNSLSNLDQDLPNNMIHQVPIKSLPQEWLWCETWCDDASKKRAKTIDLCNNPMTKE
PKLEAAVRIVPEWQDYDQEIKQLQIRFQKEKETGALYKEKTKEPSREGPQKREEL
|
| External Links |
|---|
| GenBank ID Protein
| 9910280 |
| UniProtKB/Swiss-Prot ID
| Q9NYU2 |
| UniProtKB/Swiss-Prot Entry Name
| UGGG1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_020120.3 |
| GeneCard ID
| UGGT1 |
| GenAtlas ID
| UGGT1 |
| HGNC ID
| HGNC:15663 |
| References |
|---|
| General References
| Not Available |