Identification |
HMDB Protein ID
| CDBP03299 |
Secondary Accession Numbers
| Not Available |
Name
| Transient receptor potential cation channel subfamily V member 5 |
Description
| Not Available |
Synonyms
|
- CaT2
- Calcium transport protein 2
- ECaC
- ECaC1
- Epithelial calcium channel 1
- OTRPC3
- Osm-9-like TRP channel 3
- TrpV5
|
Gene Name
| TRPV5 |
Protein Type
| Receptor |
Biological Properties |
General Function
| Involved in ion channel activity |
Specific Function
| Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)- dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating |
GO Classification
|
Component |
membrane part |
intrinsic to membrane |
integral to membrane |
cell part |
Function |
transmembrane transporter activity |
substrate-specific transmembrane transporter activity |
ion transmembrane transporter activity |
transporter activity |
ion channel activity |
Process |
establishment of localization |
transport |
ion transport |
|
Cellular Location
|
- Multi-pass membrane protein
- Apical cell membrane
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:7 |
Locus
| 7q35 |
SNPs
| TRPV5 |
Gene Sequence
|
>2190 bp
ATGGGGGGTTTTCTACCTAAGGCAGAAGGGCCCGGGAGCCAACTCCAGAAACTTCTGCCC
TCCTTTCTGGTCAGAGAACAAGACTGGGACCAGCACCTGGACAAGCTTCATATGCTGCAG
CAGAAGAGGATTCTAGAGTCTCCACTGCTTCGAGCATCCAAGGAAAATGACCTGTCTGTT
CTTAGGCAACTTCTACTGGACTGCACCTGTGACGTTCGACAAAGAGGAGCCCTGGGGGAG
ACGGCGCTGCACATAGCAGCCCTCTATGACAACTTGGAGGCGGCCTTGGTGCTGATGGAG
GCTGCCCCAGAGCTGGTCTTTGAGCCCACCACATGTGAGGCTTTTGCAGGTCAGACTGCA
CTGCACATCGCTGTTGTGAACCAGAATGTGAACCTGGTGCGTGCCCTGCTCACCCGCAGG
GCCAGTGTCTCTGCCAGAGCCACAGGCACTGCCTTCCGCCGTAGTCCCCGCAACCTCATC
TACTTTGGGGAGCACCCTTTGTCCTTTGCTGCCTGTGTGAACAGCGAGGAGATCGTGCGG
CTGCTCATTGAGCATGGAGCTGACATCAGGGCCCAGGACTCCCTGGGAAACACAGTATTA
CACATCCTCATCCTCCAGCCCAACAAAACCTTTGCCTGCCAGATGTACAACCTGCTGCTG
TCCTACGATGGACATGGGGACCACCTGCAGCCCCTGGACCTTGTGCCCAATCACCAGGGT
CTCACCCCCTTCAAGCTGGCTGGAGTGGAGGGTAACACTGTGATGTTCCAGCACCTGATG
CAGAAGCGGAGGCACATCCAGTGGACGTATGGACCCCTGACCTCCATTCTCTACGACCTC
ACAGAGATCGACTCCTGGGGAGAGGAGCTGTCCTTCCTGGAGCTTGTGGTCTCCTCTGAT
AAACGAGAGGCTCGCCAAATTCTGGAACAGACCCCAGTGAAGGAGCTGGTGAGCTTCAAG
TGGAACAAGTATGGCCGGCCGTACTTCTGCATCCTGGCTGCCTTGTACCTGCTCTACATG
ATCTGCTTTACCACGTGCTGCGTCTACCGCCCCCTTAAGTTTCGTGGTGGCAACCGCACT
CATTCTCGAGACATCACCATCCTCCAGCAAAAACTACTACAGGAGGCCTATGAGACACGT
GAAGATATCATCAGGCTGGTGGGGGAGCTGGTGAGCATCGTTGGGGCTGTGATCATCCTG
CTCCTAGAGATTCCAGACATCTTCAGGGTTGGTGCCTCTCGCTATTTTGGAAAGACGATT
CTTGGGGGGCCATTCCATGTCATCATCATCACCTATGCCTCCCTGGTGCTGGTGACCATG
GTGATGCGGCTCACCAACACCAATGGGGAGGTGGTGCCCATGTCCTTTGCCCTGGTGCTG
GGCTGGTGCAGTGTCATGTATTTCACTCGAGGATTCCAGATGCTGGGTCCCTTCACCATC
ATGATCCAGAAGATGATTTTTGGAGACCTAATGCGTTTCTGCTGGCTGATGGCTGTGGTC
ATCTTGGGATTTGCCTCCGCGTTCTATATCATTTTCCAGACAGAGGACCCAACCAGTCTG
GGGCAATTCTATGACTACCCCATGGCACTGTTCACCACCTTTGAGCTTTTTCTCACTGTT
ATTGATGCACCTGCCAACTACGACGTGGACTTGCCCTTCATGTTCAGCATTGTCAACTTC
GCCTTCGCCATCATTGCCACACTGCTCATGCTCAACTTGTTCATCGCCATGATGGGCGAC
ACCCACTGGAGGGTGGCCCAGGAGAGGGATGAGCTCTGGAGGGCCCAGGTCGTGGCCACC
ACAGTGATGCTGGAGCGGAAGCTGCCTCGCTGCCTGTGGCCTCGCTCCGGGATCTGTGGG
TGCGAATTCGGGCTGGGGGACCGCTGGTTCCTGCGGGTTGAGAACCACAATGATCAGAAT
CCTCTGCGAGTGCTTCGCTATGTGGAAGTGTTCAAGAACTCAGACAAGGAGGATGACCAG
GAGCATCCATCTGAGAAACAGCCCTCTGGGGCTGAGAGTGGGACTCTAGCCAGAGCCTCT
TTGGCTCTTCCAACTTCCTCCCTGTCCCGGACCGCGTCCCAGAGCAGCAGTCACCGAGGC
TGGGAGATCCTTCGTCAAAACACCCTGGGGCACTTGAATCTTGGACTGAACCTTAGTGAG
GGGGATGGAGAGGAGGTCTACCATTTTTGA
|
Protein Properties |
Number of Residues
| 729 |
Molecular Weight
| 82549.9 |
Theoretical pI
| 6.43 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
- ["329-349", "388-408", "420-440", "449-469", "493-513", "557-577"]
|
Protein Sequence
|
>Transient receptor potential cation channel subfamily V member 5
MGGFLPKAEGPGSQLQKLLPSFLVREQDWDQHLDKLHMLQQKRILESPLLRASKENDLSV
LRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTA
LHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVR
LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQG
LTPFKLAGVEGNTVMFQHLMQKRRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVVSSD
KREARQILEQTPVKELVSFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRT
HSRDITILQQKLLQEAYETREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTI
LGGPFHVIIITYASLVLVTMVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTI
MIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPTSLGQFYDYPMALFTTFELFLTV
IDAPANYDVDLPFMFSIVNFAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVAT
TVMLERKLPRCLWPRSGICGCEFGLGDRWFLRVENHNDQNPLRVLRYVEVFKNSDKEDDQ
EHPSEKQPSGAESGTLARASLALPTSSLSRTASQSSSHRGWEILRQNTLGHLNLGLNLSE
GDGEEVYHF
|
External Links |
GenBank ID Protein
| 17383973 |
UniProtKB/Swiss-Prot ID
| Q9NQA5 |
UniProtKB/Swiss-Prot Entry Name
| TRPV5_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AJ271207 |
GeneCard ID
| TRPV5 |
GenAtlas ID
| TRPV5 |
HGNC ID
| HGNC:3145 |
References |
General References
| Not Available |