| Identification |
|---|
| HMDB Protein ID
| CDBP03288 |
| Secondary Accession Numbers
| Not Available |
| Name
| Trichohyalin |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| TCHH |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation |
| GO Classification
|
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q21.3 |
| SNPs
| TCHH |
| Gene Sequence
|
>5832 bp
ATGTCTCCACTTCTGAGAAGCATCTGTGACATCACTGAAATTTTCAATCAGTATGTCTCT
CATGATTGTGATGGAGCAGCATTAACTAAGAAAGACCTGAAGAACCTCCTTGAAAGGGAA
TTTGGAGCTGTGCTTCGGAGACCACATGACCCTAAGACGGTAGATCTGATCCTGGAACTT
CTGGATCTTGACAGTAATGGGCGTGTCGATTTCAACGAATTCCTCCTATTTATTTTCAAA
GTGGCTCAAGCTTGTTACTATGCTCTCGGCCAGGCCACGGGACTGGATGAGGAGAAGCGA
GCCCGGTGTGACGGAAAGGAGAGCCTGTTACAAGATCGCAGGCAAGAAGAAGACCAAAGG
AGATTCGAGCCCCGGGACAGACAACTGGAAGAAGAACCTGGGCAACGACGCAGGCAGAAG
AGGCAGGAACAGGAGAGGGAGCTAGCTGAGGGAGAGGAGCAAAGTGAGAAACAAGAGCGA
CTTGAACAGCGCGACAGGCAGCGCCGCGACGAGGAGCTGTGGCGGCAAAGGCAAGAATGG
CAAGAACGGGAAGAGCGCCGTGCAGAGGAAGAGCAGCTGCAGAGTTGCAAAGGTCACGAA
ACTGAGGAGTTTCCAGACGAAGAGCAACTGCGAAGGCGGGAGCTGCTGGAGCTGAGGAGG
AAGGGCCGCGAGGAGAAACAGCAGCAAAGGCGAGAGCGGCAAGACAGAGTGTTCCAGGAG
GAAGAAGAGAAAGAGTGGAGGAAGCGCGAGACAGTGCTCCGGAAGGAAGAAGAGAAGTTG
CAGGAAGAGGAGCCGCAGCGGCAAAGAGAGCTCCAGGAGGAAGAAGAGCAGCTACGGAAG
CTGGAGCGGCAAGAGCTGAGGAGGGAGCGCCAGGAGGAAGAGCAGCAGCAGCAAAGGCTG
AGGCGCGAGCAGCAACTAAGGCGCAAGCAGGAGGAGGAGAGGCGCGAGCAGCAGGAGGAG
AGGCGCGAGCAGCAGGAGAGGCGCGAGCAGCAGGAGGAGAGGCGCGAGCAGCAGCTGAGG
CGCGAGCAGGAGGAGAGGCGCGAGCAGCAGCTGAGGCGCGAGCAGGAGGAGGAGAGGCGC
GAGCAGCAGCTGAGGCGCGAGCAGGAGGAGGAGAGGCGCGAGCAGCAGCTGAGGCGCGAG
CAGCAGCTGAGGCGCGAGCAGCAGCTGAGGCGCGAGCAGCAGCTGAGGCGCGAGCAGCAG
CTGAGGCGCGAGCAGCAGCTGAGGCGCGAGCAGCAGCTGAGGCGCGAGCAGCAGCTGAGG
CGCGAGCAGCAGCTGAGGCGCGAGCAGGAGGAGGAGAGGCACGAGCAGAAGCACGAGCAG
GAGAGGCGCGAGCAGCGGCTGAAGCGCGAGCAGGAGGAGAGGCGCGATTGGCTGAAGCGC
GAGGAGGAGACGGAGAGGCACGAGCAGGAGAGGCGCAAGCAGCAGCTGAAGCGCGACCAG
GAGGAGGAGAGGCGCGAACGTTGGCTGAAGCTCGAGGAGGAGGAGAGGCGCGAGCAGCAG
GAGAGGCGCGAGCAGCAACTAAGGCGGGAGCAAGAGGAGAGGCGCGAGCAGCGGCTGAAG
CGCCAGGAGGAGGAAGAGAGGCTCCAGCAGCGGTTGAGGAGCGAGCAACAACTAAGACGC
GAGCAGGAGGAGAGGCGCGAGCAGCTGCTGAAGCGCGAGGAGGAGAAGAGGCTCGAGCAG
GAGAGGCGAGAGCAGCGGCTGAAGCGCGAGCAGGAGGAGAGGCGCGATCAGCTGCTGAAG
CGCGAGGAGGAGAGGCGCCAGCAGCGGCTGAAGCGCGAGCAGGAAGAGAGGCTCGAGCAG
CGACTGAAGCGCGAGGAGGTGGAGAGACTCGAGCAGGAGGAGAGGCGCGAGCAGCGGCTG
AAGCGCGAGGAGCCGGAGGAAGAGAGGCGCCAGCAGCTGCTGAAGAGCGAGGAGCAGGAG
GAGAGGCGCCAGCAGCAACTAAGGCGCGAGCAGCAGGAAAGGCGCGAGCAGCGGCTGAAG
CGCGAGGAGGAGGAAGAGAGGCTCGAGCAGCGGCTGAAGCGCGAGCATGAGGAAGAGAGG
CGCGAGCAGGAGCTAGCTGAGGAGGAGCAGGAACAGGCCCGGGAGCGGATTAAGAGCCGC
ATCCCGAAGTGGCAGTGGCAGCTAGAAAGCGAGGCCGACGCACGGCAAAGCAAAGTCTAC
TCGAGGCCCCGCAAGCAGGAAGGGCAGAGGCGCCGCCAAGAGCAGGAGGAAAAGAGGCGG
CGCCGGGAGAGTGAGCTGCAATGGCAGGAGGAGGAACGGGCTCACCGGCAGCAGCAGGAA
GAGGAGCAGCGCCGGGACTTCACATGGCAGTGGCAGGCGGAGGAAAAGAGCGAGAGGGGC
CGTCAGAGGCTGTCGGCCAGGCCCCCATTGCGGGAGCAGCGGGAGAGGCAGCTGAGGGCC
GAGGAGCGCCAGCAGCGGGAACAACGGTTTCTCCCGGAGGAGGAGGAGAAGGAGCAGCGG
CGCCGCCAGCGACGCGAGAGGGAGAAAGAGCTGCAGTTCCTGGAGGAAGAGGAGCAGCTC
CAGCGGCGGGAGCGTGCCCAACAGCTCCAGGAGGAGGAGGACGGCCTCCAGGAGGATCAG
GAGAGGAGGCGAAGCCAGGAGCAGCGCCGCGACCAAAAATGGAGGTGGCAACTAGAAGAA
GAAAGGAAGAGACGCCGCCACACGCTGTACGCCAAGCCAGCCCTACAAGAGCAGCTGAGG
AAGGAACAGCAGCTGCTGCAGGAGGAGGAGGAGGAGCTACAGAGAGAGGAGCGCGAGAAG
AGAAGGCGCCAAGAACAGGAGAGACAATACCGCGAGGAAGAGCAGCTGCAGCAGGAGGAA
GAGCAGCTGCTGAGAGAGGAACGGGAGAAAAGAAGACGCCAGGAGCGGGAAAGGCAATAT
CGGAAGGATAAGAAGCTGCAGCAGAAGGAAGAGCAGCTGCTGGGAGAGGAACCGGAGAAG
AGAAGGCGCCAGGAGCGGGAGAAAAAATACCGCGAGGAAGAGGAGTTGCAGCAGGAGGAA
GAGCAGCTGCTGAGAGAGGAACGGGAGAAGAGAAGGCGCCAGGAGTGGGAGAGGCAGTAC
CGCAAAAAAGACGAGCTGCAGCAGGAAGAAGAGCAGCTGCTGAGAGAGGAACGGGAGAAA
AGAAGACTCCAGGAGCGGGAGAGGCAATATCGGGAGGAAGAGGAGCTGCAGCAGGAGGAA
GAGCAGCTGCTGGGAGAGGAACGGGAGACGAGAAGGCGCCAGGAGCTGGAGAGGCAATAT
CGGAAGGAAGAGGAGCTGCAGCAGGAGGAAGAGCAGCTGCTGAGAGAGGAACCGGAGAAG
AGAAGGCGCCAGGAGCGGGAGAGGCAATGTCGGGAGGAAGAGGAGCTGCAGCAGGAGGAA
GAGCAGCTGCTGAGAGAGGAACGGGAGAAGAGAAGGCGCCAGGAGCTGGAGAGGCAATAT
CGGGAGGAAGAGGAGGTGCAGCAGGAGGAAGAGCAGCTGCTGAGAGAGGAACCGGAGAAG
AGAAGGCGCCAGGAGCTGGAGAGGCAATACCGCGAGGAAGAGGAGCTGCAGCAGGAGGAA
GAGCAGCTGCTGAGAGAGGAACAGGAGAAAAGGCGCCAGGAGCGGGAGAGGCAGTATCGG
GAGGAGGAAGAGCTTCAGCGCCAGAAAAGGAAGCAGCGATACCGGGATGAGGATCAGCGC
AGTGATCTGAAATGGCAGTGGGAACCAGAAAAAGAAAATGCAGTTCGTGATAACAAGGTT
TACTGCAAAGGCAGAGAGAATGAACAGTTCCGGCAGTTGGAAGATTCCCAGCTGCGCGAC
AGACAATCCCAGCAAGATCTGCAGCACCTGCTGGGTGAACAGCAAGAGCGAGATCGTGAG
CAAGAGAGGAGGCGCTGGCAGCAGCGCGACAGGCATTTCCCAGAGGAAGAACAGCTGGAG
CGAGAAGAGCAAAAGGAAGCCAAAAGGCGCGACAGGAAGTCCCAAGAGGAAAAGCAGTTG
CTGAGAGAGGAAAGAGAAGAGAAGAGACGCCGTCAAGAGACAGACAGAAAATTCCGCGAG
GAGGAACAGCTGCTCCAGGAAAGGGAGGAACAGCCGCTGCGCCGCCAAGAGCGTGACAGA
AAATTCCGCGAAGAGGAACTGCGCCATCAGGAACAAGGGAGAAAATTCCTCGAGGAGGAA
CAGCGGCTGCGCCGCCAGGAACGGGAGAGAAAATTCCTTAAGGAGGAACAGCAGCTGCGC
TGCCAGGAGCGCGAGCAACAGCTGCGTCAGGACCGCGACAGAAAATTCCGCGAGGAGGAA
CAGCAGCTGAGCCGCCAAGAGCGTGACAGAAAATTCCGTGAAGAGGAACAGCAGGTGCGC
CGCCAGGAACGAGAGAGAAAATTCCTGGAGGAGGAACAGCAGCTGCGCCAGGAGCGTCAC
AGAAAATTCCGCGAAGAGGAACAGCTGCTCCAGGAAAGGGAAGAACAGCAGCTGCACCGC
CAAGAGCGTGACAGAAAATTCCTGGAGGAGGAACAACAGCTGCGCCGCCAAGAGCGTGAC
AGAAAATTCCGCGAACAGGAACTGCGCAGTCAGGAACCAGAGAGAAAATTCCTCGAGGAG
GAACAGCAGCTGCACCGCCAGCAACGGCAGAGAAAATTCCTCCAGGAGGAACAGCAGCTG
CGCCGCCAGGAGCGCGGGCAACAGCGGCGTCAGGACCGTGACAGAAAATTCCGCGAGGAG
GAACAGCTGCGCCAGGAGAGGGAGGAACAGCAGCTGAGCCGCCAAGAGCGTGACAGAAAA
TTCCGTTTAGAGGAACAGAAAGTGCGCCGCCAGGAACAAGAGAGAAAATTCATGGAGGAC
GAACAGCAGCTGCGCCGCCAGGAGGGCCAACAACAGCTGCGCCAGGAGCGCGACAGAAAA
TTCCGCGAAGACGAACAGCTGCTCCAGGAAAGGGAAGAACAGCAGCTGCACCGCCAAGAG
CGTGACAGAAAATTCCTCGAGGAGGAACCGCAGCTGCGCCGCCAGGAGCGCGAACAACAG
CTGCGTCACGACCGCGACAGAAAATTCCGTGAAGAGGAACAGCTGCTCCAGGAAGGGGAG
GAACAGCAGCTGCGCCGCCAAGAGCGTGACAGAAAATTCCGCGAAGAGGAACAGCAGCTC
CGCCGTCAGGAACGAGAGAGAAAATTCCTCCAGGAGGAACAGCAGCTGCGCCGCCAGGAA
CTGGAGAGAAAATTCCGTGAGGAGGAACAGCTGCGCCAAGAAACGGAGCAAGAGCAGCTG
CGCCGCCAAGAACGCTACAGAAAAATCCTAGAGGAAGAGCAGCTCCGTCCGGAAAGGGAA
GAACAGCAGCTGCGCCGCCAGGAGCGCGACAGAAAATTCCGCGAGGAGGAACAGCTCCGC
CAGGAGAGGGAGGAACAGCAGCTGCGCAGCCAAGAGTCTGACAGAAAATTCCGCGAGGAG
GAACAGCTACGCCAGGAGAGGGAAGAACAGCAGCTGCGCCCCCAACAGCGTGACGGAAAG
TATCGCTGGGAAGAAGAGCAGCTCCAACTTGAGGAACAAGAGCAGAGGCTGCGGCAGGAG
CGAGACCGGCAGTACCGGGCGGAGGAGCAGTTTGCCACGCAGGAGAAGAGTCGTCGTGAG
GAACAAGAACTATGGCAAGAAGAGGAGCAGAAACGTCGCCAGGAACGGGAAAGGAAATTA
CGGGAAGAACACATCCGCCGCCAGCAGAAGGAGGAACAGAGGCACCGCCAAGTCGGGGAG
ATAAAATCCCAAGAAGGGAAGGGCCATGGGCGGCTTCTGGAGCCCGGCACTCATCAGTTT
GCCAGTGTCCCAGTGCGCTCCAGCCCTCTCTATGAGTACATCCAAGAGCAGAGATCTCAA
TACCGCCCTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 1943 |
| Molecular Weight
| 253924.4 |
| Theoretical pI
| 5.49 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Trichohyalin
MSPLLRSICDITEIFNQYVSHDCDGAALTKKDLKNLLEREFGAVLRRPHDPKTVDLILEL
LDLDSNGRVDFNEFLLFIFKVAQACYYALGQATGLDEEKRARCDGKESLLQDRRQEEDQR
RFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEW
QEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQE
EEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRL
RREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERR
EQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR
REQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQ
EEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRR
EQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQ
RLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLK
REEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVY
SRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERG
RQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQL
QRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLR
KEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQY
RKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQY
RKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQY
RKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQY
REEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYR
EEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRD
RQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQL
LREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEE
QRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVR
RQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERD
RKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREE
EQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRK
FREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGE
EQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQL
RRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREE
EQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRRE
EQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTHQF
ASVPVRSSPLYEYIQEQRSQYRP
|
| External Links |
|---|
| GenBank ID Protein
| 55665869 |
| UniProtKB/Swiss-Prot ID
| Q07283 |
| UniProtKB/Swiss-Prot Entry Name
| TRHY_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AL589986 |
| GeneCard ID
| TCHH |
| GenAtlas ID
| TCHH |
| HGNC ID
| HGNC:11791 |
| References |
|---|
| General References
| Not Available |