Showing Protein Two pore calcium channel protein 2 (CDBP03283)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP03283
Secondary Accession Numbers Not Available
Name Two pore calcium channel protein 2
Description Not Available
Synonyms
  1. Voltage-dependent calcium channel protein TPC2
Gene Name TPCN2
Protein Type Transporter
Biological Properties
General Function Involved in ion channel activity
Specific Function May function as one of the major voltage-gated Ca(2+) channel (VDCC) across the plasma membrane
GO Classification
Component
membrane
cell part
Function
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
transporter activity
ion channel activity
Process
establishment of localization
transport
transmembrane transport
ion transport
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein (Potential)
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 11q13.3
SNPs TPCN2
Gene Sequence 
>2259 bp
ATGGCGGAACCCCAGGCGGAGTCGGAGCCCCTGCTGGGCGGGGCCCGCGGCGGTGGCGGC
GACTGGCCGGCGGGGCTGACCACTTACCGCAGCATCCAAGTCGGCCCTGGTGCCGCGGCC
AGGTGGGACCTCTGCATTGATCAGGCTGTGGTCTTCATCGAAGATGCTATTCAGTACCGC
TCCATCAACCACCGGGTGGATGCCAGCTCGATGTGGCTTTACCGACGGTATTACTCGAAC
GTATGCCAACGGACTTTGAGCTTCACCATCTTCTTGATCCTGTTTTTGGCTTTTATCGAG
ACCCCATCCTCACTCACCAGCACGGCGGACGTGCGCTACCGCGCTGCCCCCTGGGAGCCG
CCCTGCGGCCTGACCGAGAGTGTCGAGGTGCTCTGCCTGCTGGTCTTTGCGGCCGACCTC
TCTGTGAAGGGTTACCTGTTCGGGTGGGCCCATTTCCAGAAAAACCTTTGGCTGCTGGGC
TACCTCGTGGTGCTGGTGGTGTCTCTGGTGGACTGGACCGTGTCCCTGAGTCTCGTGTGT
CATGAGCCCCTGCGGATCCGCCGGCTTCTCCGTCCCTTCTTCCTGCTGCAGAACTCCTCT
ATGATGAAGAAGACCTTGAAATGCATCCGCTGGTCGCTGCCGGAAATGGCCAGCGTCGGG
CTGCTGCTGGCCATCCACCTGTGCCTCTTCACCATGTTCGGAATGCTGCTGTTCGCTGGT
GGGAAGCAGGATGATGGGCAGGACAGGGAGAGGCTGACCTACTTCCAGAACCTGCCTGAG
TCTCTGACTTCCCTCCTGGTGCTGCTGACCACGGCCAACAACCCCGATGTGATGATTCCT
GCGTATTCCAAGAACCGGGCCTATGCCATCTTCTTCATAGTCTTCACTGTGATAGGAAGC
CTGTTTCTGATGAACCTGCTGACAGCCATCATCTACAGTCAGTTCCGGGGCTACCTGATG
AAATCTCTCCAGACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGGCTGCCTTTGAAGTC
CTATCCTCCATGGTGGGGGAGGGAGGAGCCTTCCCTCAGGCAGTTGGGGTGAAGCCCCAG
AACTTGCTGCAGGTGCTTCAGAAGGTCCAGCTGGACAGCTCCCACAAACAGGCCATGATG
GAGAAGGTGCGTTCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGTTTCAGAAGCTCTTC
AACGAGCTTGACAGAAGTGTGGTTAAAGAGCACCCGCCGAGGCCCGAGTACCAGTCTCCG
TTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAACCTC
ATCGCCCTGGCAAACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTG
CCTGCTGAGCGTGATGACTTCATCCTGGGGATTCTCAACTGCGTCTTCATTGTGTACTAC
CTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACCCC
AGCAACGTGTTTGACGGGCTCCTCACCGTTGTCCTGCTGGTTTTGGAGATCTCAACTCTG
GCTGTGTACCGATTGCCACACCCAGGCTGGAGGCCGGAGATGGTGGGCCTGCTGTCGCTG
TGGGACATGACCCGCATGCTGAACATGCTCATCGTGTTCCGCTTCCTGCGTATCATCCCC
AGCATGAAGCTGATGGCCGTGGTGGCCAGTACCGTCCTGGGCCTGGTGCAGAACATGCGT
GCGTTTGGCGGGATCCTGGTGGTGGTCTACTACGTATTTGCCATCATTGGGATCAACTTG
TTTAGAGGCGTCATTGTGGCTCTTCCTGGAAACAGCAGCCTGGCCCCTGCCAATGGCTCG
GCGCCCTGTGGGAGCTTCGAGCAGCTGGAGTACTGGGCCAACAACTTCGATGACTTTGCG
GCTGCCCTGGTCACTCTGTGGAACTTGATGGTGGTGAACAACTGGCAGGTGTTTCTGGAT
GCATATCGGCGCTACTCAGGCCCGTGGTCCAAGATCTATTTTGTATTGTGGTGGCTGGTG
TCGTCTGTCATCTGGGTCAACCTGTTTCTGGCCCTGATTCTGGAGAACTTCCTTCACAAG
TGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTGGGACCCCAGAGGCCACCTACCAGATG
ACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAGAG
AGGCTGAGCCAGCACCCGCACCTGTGGCTGTGCAGGTGA
Protein Properties
Number of Residues 752
Molecular Weight 85242.1
Theoretical pI 7.1
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["85-105", "156-176", "219-239", "290-310", "337-357", "440-460", "466-486", "503-523", "555-575", "581-601", "639-659", "674-694"]
Protein Sequence 
>Two pore calcium channel protein 2
MAEPQAESEPLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYR
SINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEP
PCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC
HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG
GKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGS
LFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQ
NLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSP
FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYY
LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL
WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL
FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLD
AYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQM
TVELLFRDILEEPGEDELTERLSQHPHLWLCR
GenBank ID Protein 157502181
UniProtKB/Swiss-Prot ID Q8NHX9
UniProtKB/Swiss-Prot Entry Name TPC2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_139075.3
GeneCard ID TPCN2
GenAtlas ID TPCN2
HGNC ID HGNC:20820
References
General References Not Available