| Identification |
|---|
| HMDB Protein ID
| CDBP03281 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protein tyrosine phosphatase type IVA 3 |
| Description
| Not Available |
| Synonyms
|
- PRL-3
- PRL-R
- Protein-tyrosine phosphatase 4a3
- Protein-tyrosine phosphatase of regenerating liver 3
|
| Gene Name
| PTP4A3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphatase activity |
| Specific Function
| Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
|
| GO Classification
|
| Cellular Component |
| plasma membrane |
| early endosome |
| Function |
| phosphoprotein phosphatase activity |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| protein tyrosine/serine/threonine phosphatase activity |
| Molecular Function |
| prenylated protein tyrosine phosphatase activity |
| Process |
| metabolic process |
| cellular metabolic process |
| phosphorus metabolic process |
| phosphate metabolic process |
| dephosphorylation |
| protein amino acid dephosphorylation |
|
| Cellular Location
|
- Cell membrane
- Early endosome
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| 8q24.3 |
| SNPs
| PTP4A3 |
| Gene Sequence
|
>522 bp
ATGGCTCGGATGAACCGCCCGGCCCCGGTGGAGGTGAGCTACAAACACATGCGCTTCCTC
ATCACCCACAACCCCACCAACGCCACGCTCAGCACCTTCATTGAGGACCTGAAGAAGTAC
GGGGCTACCACTGTGGTGCGTGTGTGTGAAGTGACCTATGACAAAACGCCGCTGGAGAAG
GATGGCATCACCGTTGTGGACTGGCCGTTTGACGATGGGGCGCCCCCGCCTGGCAAGGTA
GTGGAAGACTGGCTGAGCCTGGTGAAGGCCAAGTTCTGTGAGGCCCCCGGCAGCTGCGTG
GCTGTGCACTGCGTGGCGGGCCTGGGGCGGGCTCCAGTCCTTGTGGCGCTGGCGCTTATT
GAGAGCGGGATGAAGTACGAGGACGCCATCCAGTTCATCCGCCAGAAGCGCCGCGGACGC
ATCAACAGCAAGCAGCTCACCTACCTGGAGAAATACCGGCCCAAACAGAGGCTGCGGTTC
AAAGACCCACACACGCACAAGACCCGGTGCTGCGTTATGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 173 |
| Molecular Weight
| 16776.455 |
| Theoretical pI
| 9.385 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Protein tyrosine phosphatase type IVA 3
MARMNRPAPVEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEK
DGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALI
ESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQRLRFKDPHTHKTRCCVM
|
| External Links |
|---|
| GenBank ID Protein
| 3406430 |
| UniProtKB/Swiss-Prot ID
| O75365 |
| UniProtKB/Swiss-Prot Entry Name
| TP4A3_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF041434 |
| GeneCard ID
| PTP4A3 |
| GenAtlas ID
| PTP4A3 |
| HGNC ID
| HGNC:9636 |
| References |
|---|
| General References
| Not Available |