Identification
HMDB Protein ID CDBP03272
Secondary Accession Numbers Not Available
Name Troponin C, skeletal muscle
Description Not Available
Synonyms Not Available
Gene Name TNNC2
Protein Type Metal Binding
Biological Properties
General Function Involved in calcium ion binding
Specific Function Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components:Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location Chromosome:2
Locus 20q12-q13.11
SNPs TNNC2
Gene Sequence
>483 bp
ATGACGGACCAGCAGGCTGAGGCCAGGTCCTACCTCAGCGAAGAGATGATCGCTGAGTTC
AAGGCTGCCTTTGACATGTTTGATGCTGATGGTGGTGGGGACATCAGCGTCAAGGAGTTG
GGCACGGTGATGAGGATGCTGGGCCAGACACCCACCAAGGAGGAGCTGGACGCCATCATC
GAGGAGGTGGATGAGGACGGCAGCGGCACCATCGACTTCGAGGAGTTCTTGGTCATGATG
GTGCGCCAGATGAAAGAGGACGCGAAAGGGAAGAGCGAGGAGGAGCTGGCCGAGTGCTTC
CGCATCTTCGACAGGAATGCAGACGGCTACATCGACCCGGAGGAGCTGGCTGAGATTTTC
AGGGCCTCCGGGGAGCACGTGACGGACGAGGAGATCGAATCTCTGATGAAAGACGGCGAC
AAGAACAACGACGGCCGCATTGACTTCGACGAGTTCCTGAAGATGATGGAGGGCGTGCAG
TAA
Protein Properties
Number of Residues 160
Molecular Weight 18121.9
Theoretical pI 3.81
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>Troponin C, skeletal muscle
MTDQQAEARSYLSEEMIAEFKAAFDMFDADGGGDISVKELGTVMRMLGQTPTKEELDAII
EEVDEDGSGTIDFEEFLVMMVRQMKEDAKGKSEEELAECFRIFDRNADGYIDPEELAEIF
RASGEHVTDEEIESLMKDGDKNNDGRIDFDEFLKMMEGVQ
GenBank ID Protein 4507617
UniProtKB/Swiss-Prot ID P02585
UniProtKB/Swiss-Prot Entry Name TNNC2_HUMAN
PDB IDs
GenBank Gene ID NM_003279.2
GeneCard ID TNNC2
GenAtlas ID TNNC2
HGNC ID HGNC:11944
References
General References Not Available