Identification
HMDB Protein ID CDBP03247
Secondary Accession Numbers Not Available
Name Synaptotagmin-6
Description Not Available
Synonyms
  1. Synaptotagmin VI
  2. SytVI
Gene Name SYT6
Protein Type Transporter
Biological Properties
General Function Involved in transporter activity
Specific Function May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis
GO Classification
Component
coated vesicle
clathrin-coated vesicle
synaptic vesicle
membrane
cell part
organelle
vesicle
cytoplasmic vesicle
cytoplasmic membrane-bounded vesicle
Function
transporter activity
Process
establishment of localization
transport
Cellular Location
  1. Cytoplasmic vesicle
  2. Single-pass membrane protein
  3. secretory vesicle
  4. synaptic vesicle membrane
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 1p13.2
SNPs SYT6
Gene Sequence
>2840 bp
ATGAGCGGAGTGTGGGGGGCCGGCGGGCCTCGGTGCCAGGAGGCGCTCGCGGTCCTCGCC
TCGCTGTGCCGGGCCCGGCCGCCCCCTCTCGGGCTGGACGTGGAGACTTGTCGGAGCTTC
GAGCTGCAGCCCCCAGAGCGGAGTCCCAGCGCGGCAGGCGCAGGCACCTCTGTCAGCCTC
CTCGCAGTTGTAGTTATTGTGTGTGGCGTGGCCCTGGTGGCAGTTTTTCTCTTTCTCTTT
TGGAAGCTGTGCTGGATGCCCTGGAGGAACAAGGAGGCCTCCAGTCCCTCTTCTGCTAAT
CCCCCCTTGGAAGCCCTCCAGAGCCCCAGCTTCAGAGGCAACATGGCGGACAAGCTGAAG
GACCCCAGCACCCTGGGCTTCCTGGAGGCGGCCGTGAAGATCAGCCACACGTCCCCAGAT
ATCCCAGCTGAGGTGCAGATGTCGGTCAAGGAGCACATCATGCGTCACACCCGGCTGCAG
CGGCAAACTACAGAGCCAGCGTCATCCACCAGGCACACGTCCTTCAAGCGCCACCTGCCA
AGGCAGATGCATGTCTCCAGTGTAGACTATGGCAATGAGCTTCCACCAGCAGCAGAGCAG
CCCACCAGCATTGGCCGCATCAAGCCTGAGCTCTACAAGCAGAAGTCGGTGGATGGGGAG
GATGCCAAGTCTGAGGCCACCAAGAGCTGCGGGAAGATCAACTTCAGCCTACGCTACGAT
TACGAGACCGAGACCCTGATTGTGCGTATCCTGAAGGCTTTTGACCTCCCTGCCAAGGAC
TTTTGTGGAAGCTCTGACCCTTATGTCAAGATCTACCTCCTGCCTGACCGCAAATGCAAG
CTGCAGACCCGGGTGCACCGCAAGACCCTGAACCCCACCTTTGATGAGAACTTCCACTTC
CCTGTGCCCTATGAGGAGCTGGCTGACCGCAAGCTGCATCTCAGTGTCTTCGACTTTGAC
CGCTTCTCCCGCCATGACATGATTGGCGAGGTCATCCTGGACAACCTCTTTGAGGCCTCT
GACCTGTCTCGGGAAACCTCCATCTGGAAGGATATCCAATATGCCACAAGTGAAAGCGTG
GACTTGGGAGAGATCATGTTCTCCCTTTGCTACCTGCCCACTGCAGGCAGGCTCACCCTC
ACAGTGATTAAGTGTCGGAACCTCAAGGCGATGGACATCACAGGCTATTCAGATCCCTAT
GTGAAAGTGTCCTTGCTCTGTGATGGGCGGAGGCTGAAGAAGAAGAAAACAACCATAAAG
AAAAACACTCTCAATCCTGTCTACAATGAGGCCATCATCTTTGACATTCCCCCGGAAAAC
ATGGATCAAGTCAGCCTGCTCATCTCAGTCATGGACTATGATCGAGTGGGCCACAATGAG
ATCATAGGAGTCTGTCGTGTGGGGATCACTGCTGAAGGCCTGGGCAGGGACCACTGGAAC
GAGATGCTGGCATACCCCCGGAAGCCCATCGCACACTGGCACTCCTTGGTGGAGGTAAAG
AAATCCTTCAAAGAGGGAAACCCTCGGTTGTGA
Protein Properties
Number of Residues 510
Molecular Weight 57324.4
Theoretical pI 8.29
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["60-80"]
Protein Sequence
>Synaptotagmin-6
MSGVWGAGGPRCQEALAVLASLCRARPPPLGLDVETCRSFELQPPERSPSAAGAGTSVSL
LAVVVIVCGVALVAVFLFLFWKLCWMPWRNKEASSPSSANPPLEALQSPSFRGNMADKLK
DPSTLGFLEAAVKISHTSPDIPAEVQMSVKEHIMRHTRLQRQTTEPASSTRHTSFKRHLP
RQMHVSSVDYGNELPPAAEQPTSIGRIKPELYKQKSVDGEDAKSEATKSCGKINFSLRYD
YETETLIVRILKAFDLPAKDFCGSSDPYVKIYLLPDRKCKLQTRVHRKTLNPTFDENFHF
PVPYEELADRKLHLSVFDFDRFSRHDMIGEVILDNLFEASDLSRETSIWKDIQYATSESV
DLGEIMFSLCYLPTAGRLTLTVIKCRNLKAMDITGYSDPYVKVSLLCDGRRLKKKKTTIK
KNTLNPVYNEAIIFDIPPENMDQVSLLISVMDYDRVGHNEIIGVCRVGITAEGLGRDHWN
EMLAYPRKPIAHWHSLVEVKKSFKEGNPRL
GenBank ID Protein 123273719
UniProtKB/Swiss-Prot ID Q5T7P8
UniProtKB/Swiss-Prot Entry Name SYT6_HUMAN
PDB IDs Not Available
GenBank Gene ID AL162594
GeneCard ID SYT6
GenAtlas ID SYT6
HGNC ID HGNC:18638
References
General References Not Available