Identification
HMDB Protein ID CDBP03238
Secondary Accession Numbers Not Available
Name Synaptophysin
Description Not Available
Synonyms
  1. Major synaptic vesicle protein p38
Gene Name SYP
Protein Type Transporter
Biological Properties
General Function Involved in transporter activity
Specific Function Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity
GO Classification
Component
cytoplasmic vesicle
cytoplasmic membrane-bounded vesicle
coated vesicle
clathrin-coated vesicle
synaptic vesicle
membrane
cell part
membrane part
intrinsic to membrane
organelle
integral to membrane
vesicle
Function
transporter activity
Process
establishment of localization
transport
Cellular Location
  1. Cytoplasmic vesicle
  2. Multi-pass membrane protein
  3. secretory vesicle
  4. Cell junction
  5. synapse
  6. synaptosome
  7. synaptic vesicle membrane
Pathways
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs SYP
Gene Sequence
>942 bp
ATGCTGCTGCTGGCGGACATGGACGTGGTGAATCAGCTGGTGGCTGGGGGTCAGTTCCGG
GTGGTCAAGGAGCCCCTCGGCTTTGTGAAGGTGCTGCAATGGGTCTTCGCCATCTTCGCC
TTTGCCACATGCGGCAGCTACAGTGGGGAGCTCCAGCTGAGCGTGGATTGTGCCAACAAG
ACCGAGAGTGACCTCAGCATCGAGGTCGAGTTCGAGTACCCCTTCAGGCTGCACCAAGTG
TACTTTGATGCACCCACCTGCCGAGGGGGCACCACCAAGGTCTTCTTAGTTGGGGACTAC
TCCTCGTCAGCCGAATTCTTTGTCACCGTGGCCGTGTTTGCCTTCCTCTACTCCATGGGG
GCTCTGGCCACCTACATCTTCCTGCAGAACAAGTACCGAGAGAATAACAAAGGGCCCATG
CTGGACTTTCTGGCCACGGCTGTGTTCGCCTTCATGTGGCTAGTTAGCTCATCGGCATGG
GCCAAGGGGCTGTCAGATGTGAAGATGGCCACAGACCCAGAGAACATTATCAAGGAGATG
CCTGTCTGCCGCCAGACAGGGAACACATGCAAGGAGCTGAGAGACCCTGTGACCTCGGGA
CTCAACACCTCGGTGGTGTTCGGCTTCCTGAACCTGGTGCTCTGGGTCGGCAACCTGTGG
TTCGTGTTTAAGGAGACAGGCTGGGCCGCCCCGTTCCTGCGCGCGCCTCCCGGCGCCCCC
GAGAAACAACCGGCACCCGGGGACGCCTACGGCGATGCAGGCTACGGGCAGGGCCCCGGC
GGGTACGGGCCCCAGGATTCCTACGGGCCTCAGGGCGGCTACCAGCCTGACTATGGTCAA
CCAGCCGGCAGCGGTGGCAGTGGCTACGGGCCTCAGGGCGACTATGGGCAGCAAGGCTAC
GGCCCGCAGGGTGCACCCACCTCCTTCTCCAATCAGATGTAG
Protein Properties
Number of Residues 313
Molecular Weight 33845.1
Theoretical pI 4.41
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["26-49", "107-130", "138-161", "200-223"]
Protein Sequence
>Synaptophysin
MLLLADMDVVNQLVAGGQFRVVKEPLGFVKVLQWVFAIFAFATCGSYSGELQLSVDCANK
TESDLSIEVEFEYPFRLHQVYFDAPTCRGGTTKVFLVGDYSSSAEFFVTVAVFAFLYSMG
ALATYIFLQNKYRENNKGPMLDFLATAVFAFMWLVSSSAWAKGLSDVKMATDPENIIKEM
PVCRQTGNTCKELRDPVTSGLNTSVVFGFLNLVLWVGNLWFVFKETGWAAPFLRAPPGAP
EKQPAPGDAYGDAGYGQGPGGYGPQDSYGPQGGYQPDYGQPAGSGGSGYGPQGDYGQQGY
GPQGAPTSFSNQM
GenBank ID Protein 189053611
UniProtKB/Swiss-Prot ID P08247
UniProtKB/Swiss-Prot Entry Name SYPH_HUMAN
PDB IDs Not Available
GenBank Gene ID AK313030
GeneCard ID SYP
GenAtlas ID SYP
HGNC ID HGNC:11506
References
General References Not Available