| Identification |
|---|
| HMDB Protein ID
| CDBP03233 |
| Secondary Accession Numbers
| Not Available |
| Name
| Extracellular sulfatase Sulf-2 |
| Description
| Not Available |
| Synonyms
|
- hSulf-2
|
| Gene Name
| SULF2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin |
| GO Classification
|
| Component |
| golgi apparatus |
| cell part |
| endoplasmic reticulum |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| cell surface |
| Function |
| cation binding |
| metal ion binding |
| hydrolase activity, acting on ester bonds |
| binding |
| catalytic activity |
| hydrolase activity |
| sulfuric ester hydrolase activity |
| calcium ion binding |
| ion binding |
| Process |
| metabolic process |
|
| Cellular Location
|
- Golgi apparatus
- Endoplasmic reticulum
- Golgi stack
- Cell surface
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 20q12-q13.2 |
| SNPs
| SULF2 |
| Gene Sequence
|
>2613 bp
ATGGGCCCCCCGAGCCTCGTGCTGTGCTTGCTGTCCGCAACTGTGTTCTCCCTGCTGGGT
GGAAGCTCGGCCTTCCTGTCGCACCACCGCCTGAAAGGCAGGTTTCAGAGGGACCGCAGG
AACATCCGCCCCAACATCATCCTGGTGCTGACGGACGACCAGGATGTGGAGCTGGGTTCC
ATGCAGGTGATGAACAAGACCCGGCGCATCATGGAGCAGGGCGGGGCGCACTTCATCAAC
GCCTTCGTGACCACACCCATGTGCTGCCCCTCACGCTCCTCCATCCTCACTGGCAAGTAC
GTCCACAACCACAACACCTACACCAACAATGAGAACTGCTCCTCGCCCTCCTGGCAGGCA
CAGCACGAGAGCCGCACCTTTGCCGTGTACCTCAATAGCACTGGCTACCGGACAGCTTTC
TTCGGGAAGTATCTTAATGAATACAACGGCTCCTACGTGCCACCCGGCTGGAAGGAGTGG
GTCGGACTCCTTAAAAACTCCCGCTTTTATAACTACACGCTGTGTCGGAACGGGGTGAAA
GAGAAGCACGGCTCCGACTACTCCAAGGATTACCTCACAGACCTCATCACCAATGACAGC
GTGAGCTTCTTCCGCACGTCCAAGAAGATGTACCCGCACAGGCCAGTCCTCATGGTCATC
AGCCATGCAGCCCCCCACGGCCCTGAGGATTCAGCCCCACAATATTCACGCCTCTTCCCA
AACGCATCTCAGCACATCACGCCGAGCTACAACTACGCGCCCAACCCGGACAAACACTGG
ATCATGCGCTACACGGGGCCCATGAAGCCCATCCACATGGAATTCACCAACATGCTCCAG
CGGAAGCGCTTGCAGACCCTCATGTCGGTGGACGACTCCATGGAGACGATTTACAACATG
CTGGTTGAGACGGGCGAGCTGGACAACACGTACATCGTATACACCGCCGACCACGGTTAC
CACATCGGCCAGTTTGGCCTGGTGAAAGGGAAATCCATGCCATATGAGTTTGACATCAGG
GTCCCGTTCTACGTGAGGGGCCCCAACGTGGAAGCCGGCTGTCTGAATCCCCACATCGTC
CTCAACATTGACCTGGCCCCCACCATCCTGGACATTGCAGGCCTGGACATACCTGCGGAT
ATGGACGGGAAATCCATCCTCAAGCTGCTGGACACGGAGCGGCCGGTGAATCGGTTTCAC
TTGAAAAAGAAGATGAGGGTCTGGCGGGACTCCTTCTTGGTGGAGAGAGGCAAGCTGCTA
CACAAGAGAGACAATGACAAGGTGGACGCCCAGGAGGAGAACTTTCTGCCCAAGTACCAG
CGTGTGAAGGACCTGTGTCAGCGTGCTGAGTACCAGACGGCGTGTGAGCAGCTGGGACAG
AAGTGGCAGTGTGTGGAGGACGCCACGGGGAAGCTGAAGCTGCATAAGTGCAAGGGCCCC
ATGCGGCTGGGCGGCAGCAGAGCCCTCTCCAACCTCGTGCCCAAGTACTACGGGCAGGGC
AGCGAGGCCTGCACCTGTGACAGCGGGGACTACAAGCTCAGCCTGGCCGGACGCCGGAAA
AAACTCTTCAAGAAGAAGTACAAGGCCAGCTATGTCCGCAGTCGCTCCATCCGCTCAGTG
GCCATCGAGGTGGACGGCAGGGTGTACCACGTAGGCCTGGGTGATGCCGCCCAGCCCCGA
AACCTCACCAAGCGGCACTGGCCAGGGGCCCCTGAGGACCAAGATGACAAGGATGGTGGG
GACTTCAGTGGCACTGGAGGCCTTCCCGACTACTCAGCCGCCAACCCCATTAAAGTGACA
CATCGGTGCTACATCCTAGAGAACGACACAGTCCAGTGTGACCTGGACCTGTACAAGTCC
CTGCAGGCCTGGAAAGACCACAAGCTGCACATCGACCACGAGATTGAAACCCTGCAGAAC
AAAATTAAGAACCTGAGGGAAGTCCGAGGTCACCTGAAGAAAAAGCGGCCAGAAGAATGT
GACTGTCACAAAATCAGCTACCACACCCAGCACAAAGGCCGCCTCAAGCACAGAGGCTCC
AGTCTGCATCCTTTCAGGAAGGGCCTGCAAGAGAAGGACAAGGTGTGGCTGTTGCGGGAG
CAGAAGCGCAAGAAGAAACTCCGCAAGCTGCTCAAGCGCCTGCAGAACAACGACACGTGC
AGCATGCCAGGCCTCACGTGCTTCACCCACGACAACCAGCACTGGCAGACGGCGCCTTTC
TGGACACTGGGGCCTTTCTGTGCCTGCACCAGCGCCAACAATAACACGTACTGGTGCATG
AGGACCATCAATGAGACTCACAATTTCCTCTTCTGTGAATTTGCAACTGGCTTCCTAGAG
TACTTTGATCTCAACACAGACCCCTACCAGCTGATGAATGCAGTGAACACACTGGACAGG
GATGTCCTCAACCAGCTACACGTACAGCTCATGGAGCTGAGGAGCTGCAAGGGTTACAAG
CAGTGTAACCCCCGGACTCGAAACATGGACCTGGGACTTAAAGATGGAGGAAGCTATGAG
CAATACAGGCAGTTTCAGCGTCGAAAGTGGCCAGAAATGAAGAGACCTTCTTCCAAATCA
CTGGGACAACTGTGGGAAGGCTGGGAAGGTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 870 |
| Molecular Weight
| 100454.0 |
| Theoretical pI
| 9.54 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Extracellular sulfatase Sulf-2
MGPPSLVLCLLSATVFSLLGGSSAFLSHHRLKGRFQRDRRNIRPNIILVLTDDQDVELGS
MQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGKYVHNHNTYTNNENCSSPSWQA
QHESRTFAVYLNSTGYRTAFFGKYLNEYNGSYVPPGWKEWVGLLKNSRFYNYTLCRNGVK
EKHGSDYSKDYLTDLITNDSVSFFRTSKKMYPHRPVLMVISHAAPHGPEDSAPQYSRLFP
NASQHITPSYNYAPNPDKHWIMRYTGPMKPIHMEFTNMLQRKRLQTLMSVDDSMETIYNM
LVETGELDNTYIVYTADHGYHIGQFGLVKGKSMPYEFDIRVPFYVRGPNVEAGCLNPHIV
LNIDLAPTILDIAGLDIPADMDGKSILKLLDTERPVNRFHLKKKMRVWRDSFLVERGKLL
HKRDNDKVDAQEENFLPKYQRVKDLCQRAEYQTACEQLGQKWQCVEDATGKLKLHKCKGP
MRLGGSRALSNLVPKYYGQGSEACTCDSGDYKLSLAGRRKKLFKKKYKASYVRSRSIRSV
AIEVDGRVYHVGLGDAAQPRNLTKRHWPGAPEDQDDKDGGDFSGTGGLPDYSAANPIKVT
HRCYILENDTVQCDLDLYKSLQAWKDHKLHIDHEIETLQNKIKNLREVRGHLKKKRPEEC
DCHKISYHTQHKGRLKHRGSSLHPFRKGLQEKDKVWLLREQKRKKKLRKLLKRLQNNDTC
SMPGLTCFTHDNQHWQTAPFWTLGPFCACTSANNNTYWCMRTINETHNFLFCEFATGFLE
YFDLNTDPYQLMNAVNTLDRDVLNQLHVQLMELRSCKGYKQCNPRTRNMDLGLKDGGSYE
QYRQFQRRKWPEMKRPSSKSLGQLWEGWEG
|
| External Links |
|---|
| GenBank ID Protein
| 240255483 |
| UniProtKB/Swiss-Prot ID
| Q8IWU5 |
| UniProtKB/Swiss-Prot Entry Name
| SULF2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001161841.1 |
| GeneCard ID
| SULF2 |
| GenAtlas ID
| SULF2 |
| HGNC ID
| HGNC:20392 |
| References |
|---|
| General References
| Not Available |