Cannabis Compound Database: Showing Protein Alpha-1-syntrophin (CDBP03215)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP03215

Secondary Accession Numbers

Not Available

Name

Alpha-1-syntrophin

Description

Not Available

Synonyms

59 kDa dystrophin-associated protein A1 acidic component 1
Pro-TGF-alpha cytoplasmic domain-interacting protein 1
Syntrophin-1
TACIP1

Gene Name

SNTA1

Protein Type

Enzyme

Biological Properties

General Function

Involved in protein binding

Specific Function

Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5- biphosphate

GO Classification

Function
binding
protein binding

Cellular Location

Cell membrane
Cytoplasm
Peripheral membrane protein
Cytoplasmic side
cytoskeleton
Cell junction
sarcolemma

Pathways

Name	SMPDB/Pathwhiz	KEGG
Muscle/Heart Contraction		Not Available
Acebutolol Action Pathway		Not Available
Alprenolol Action Pathway		Not Available
Atenolol Action Pathway		Not Available
Betaxolol Action Pathway		Not Available

Gene Properties

Chromosome Location

Chromosome:2

Locus

20q11.2

SNPs

SNTA1

Gene Sequence

>1518 bp
ATGGCGTCCGGCAGGCGCGCCCCGCGCACCGGGCTGCTGGAGCTGCGCGCCGGGGCGGGC
TCGGGGGCCGGCGGCGAGCGATGGCAGCGGGTGCTGCTGAGTCTGGCGGAGGACGTGCTG
ACCGTGAGCCCCGCCGACGGCGACCCTGGTCCCGAGCCCGGCGCTCCGCGGGAGCAGGAG
CCCGCGCAGCTCAACGGCGCCGCGGAGCCGGGCGCCGGGCCCCCGCAGCTGCCAGAGGCG
CTACTGCTCCAGCGGCGCCGCGTGACGGTGCGCAAGGCCGACGCCGGTGGGCTGGGCATC
AGCATCAAAGGCGGCCGGGAGAACAAGATGCCTATTCTCATTTCCAAGATCTTCAAGGGA
TTGGCAGCTGACCAGACAGAGGCCCTTTTTGTGGGGGATGCCATCCTGTCTGTGAATGGG
GAAGACTTGTCCTCTGCTACCCATGATGAGGCGGTGCAGGTCCTCAAGAAGACAGGCAAG
GAGGTGGTGCTGGAGGTCAAGTATATGAAGGACGTCTCACCGTATTTCAAGAACTCTACT
GGTGGGACCTCGGTCGGCTGGGACTCACCTCCTGCCTCACCCCTTCAGCGGCAGCCTTCC
TCCCCTGGCCCCACACCCCGGAACTTCAGCGAGGCCAAACACATGTCCTTGAAGATGGCA
TATGTCTCGAAGAGGTGCACCCCCAATGACCCGGAGCCCAGGTATCTGGAGATCTGCTCG
GCAGATGGTCAAGACACCCTCTTCCTGAGGGCCAAGGATGAGGCTAGTGCGAGGTCGTGG
GCGACTGCCATCCAAGCCCAGGTCAATACTCTGACGCCGCGGGTCAAGGATGAGCTGCAG
GCACTGTTGGCAGCCACCAGCACAGCTGGGAGCCAGGACATCAAGCAGATTGGCTGGCTA
ACTGAGCAGCTGCCCAGTGGGGGCACAGCCCCCACCCTGGCCCTGCTAACTGAAAAGGAA
CTGCTCCTCTACTTGTCTCTCCCCGAGACCCGCGAGGCCCTGAGCCGGCCAGCCCGTACT
GCCCCACTCATCGCCACCAGACTGGTGCACTCAGGCCCCTCCAAGGGCTCAGTGCCCTAC
GATGCAGAGCTCTCTTTTGCCCTGCGCACGGGCACGCGTCACGGTGTGGACACTCACCTG
TTCAGCGTGGAGTCACCGCAGGAGCTGGCTGCCTGGACCCGCCAGCTTGTGGATGGCTGT
CACCGGGCCGCCGAGGGTGTGCAGGAGGTGTCTACAGCCTGCACGTGGAATGGGCGTCCC
TGCAGCCTGTCTGTGCACATCGACAAGGGCTTCACACTGTGGGCGGCTGAGCCAGGTGCA
GCCCGAGCTGTGCTCCTGCGACAGCCCTTCGAGAAGCTGCAGATGTCTTCAGATGACGGT
GCCAGTCTCCTTTTCCTGGATTTTGGAGGTGCTGAAGGCGAGATCCAGCTGGACCTGCAC
TCGTGTCCCAAAACCATAGTCTTCATCATCCACTCCTTCCTGTCGGCCAAAGTCACCCGC
CTCGGGCTGTTGGCCTAG

Protein Properties

Number of Residues

505

Molecular Weight

53894.7

Theoretical pI

6.79

Pfam Domain Function

PDZ (PF00595 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>Alpha-1-syntrophin
MASGRRAPRTGLLELRAGAGSGAGGERWQRVLLSLAEDVLTVSPADGDPGPEPGAPREQE
PAQLNGAAEPGAGPPQLPEALLLQRRRVTVRKADAGGLGISIKGGRENKMPILISKIFKG
LAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEVKYMKDVSPYFKNST
GGTSVGWDSPPASPLQRQPSSPGPTPRNFSEAKHMSLKMAYVSKRCTPNDPEPRYLEICS
ADGQDTLFLRAKDEASARSWATAIQAQVNTLTPRVKDELQALLAATSTAGSQDIKQIGWL
TEQLPSGGTAPTLALLTEKELLLYLSLPETREALSRPARTAPLIATRLVHSGPSKGSVPY
DAELSFALRTGTRHGVDTHLFSVESPQELAAWTRQLVDGCHRAAEGVQEVSTACTWNGRP
CSLSVHIDKGFTLWAAEPGAARAVLLRQPFEKLQMSSDDGASLLFLDFGGAEGEIQLDLH
SCPKTIVFIIHSFLSAKVTRLGLLA

External Links

GenBank ID Protein

158257420

UniProtKB/Swiss-Prot ID

Q13424

UniProtKB/Swiss-Prot Entry Name

SNTA1_HUMAN

PDB IDs