Identification
HMDB Protein ID CDBP03214
Secondary Accession Numbers Not Available
Name SRC kinase signaling inhibitor 1
Description Not Available
Synonyms
  1. SNAP-25-interacting protein
  2. SNIP
  3. p130Cas-associated protein
  4. p140Cap
Gene Name SRCIN1
Protein Type Enzyme
Biological Properties
General Function Involved in protein kinase binding
Specific Function Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance
GO Classification Not Available
Cellular Location
  1. Cytoplasm
  2. Cytoplasm
  3. cytoskeleton
  4. Cell junction
  5. Cell junction
  6. synapse
  7. synapse
  8. Cell projection
  9. Cell projection
  10. postsynaptic cell membrane
  11. postsynaptic density
  12. dendrite
  13. axon
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 17q12
SNPs SRCIN1
Gene Sequence Not Available
Protein Properties
Number of Residues 1055
Molecular Weight 112452.4
Theoretical pI 9.82
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>SRC kinase signaling inhibitor 1
MRGAWVHLHSGAASSLRPCRCGAGAAPKSSPRSPGGRRGDGSSDSEGGVSFAGVLFLQFG
EETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDVRD
IQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPAPHLASGSP
PPGLPSGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAI
LERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYK
RGSVRSLSTYSAAALQSDLEDSLYKAAGGGGPLYGDGYGFRLPPSSPQKLADVAAPPGGP
PPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPG
ERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEKIEGSNGAA
TPSAPCGSGGRSSGATPVSGPPPPSASSTPAGQPTAVSRLQMQLHLRGLQNSASDLRGQL
QQLRKLQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEEL
ITQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKALVLKQLGETLTELKAHFPGLQSKMR
VVLRVEVEAVKFLKEEPQRLDGLLKRCRGVTDTLAQIRRQVDEGVWPPPNNLLSQSPKKV
TAETDFNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVDKAVSV
EAAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKAHPGPAPTPDHKPPK
APHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVV
VTSKKDSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAE
LESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSKHGKQRAEYMRIQAQQQATKPSKEMS
GSNETSSPVSEKPSASRTSIPVLTSFGARNSSISF
GenBank ID Protein 115334682
UniProtKB/Swiss-Prot ID Q9C0H9
UniProtKB/Swiss-Prot Entry Name SRCN1_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID SRCIN1
GenAtlas ID SRCIN1
HGNC ID HGNC:29506
References
General References Not Available