Identification |
HMDB Protein ID
| CDBP03214 |
Secondary Accession Numbers
| Not Available |
Name
| SRC kinase signaling inhibitor 1 |
Description
| Not Available |
Synonyms
|
- SNAP-25-interacting protein
- SNIP
- p130Cas-associated protein
- p140Cap
|
Gene Name
| SRCIN1 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in protein kinase binding |
Specific Function
| Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance |
GO Classification
|
Not Available
|
Cellular Location
|
- Cytoplasm
- Cytoplasm
- cytoskeleton
- Cell junction
- Cell junction
- synapse
- synapse
- Cell projection
- Cell projection
- postsynaptic cell membrane
- postsynaptic density
- dendrite
- axon
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 17q12 |
SNPs
| SRCIN1 |
Gene Sequence
|
Not Available
|
Protein Properties |
Number of Residues
| 1055 |
Molecular Weight
| 112452.4 |
Theoretical pI
| 9.82 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>SRC kinase signaling inhibitor 1
MRGAWVHLHSGAASSLRPCRCGAGAAPKSSPRSPGGRRGDGSSDSEGGVSFAGVLFLQFG
EETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDVRD
IQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPAPHLASGSP
PPGLPSGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAI
LERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYK
RGSVRSLSTYSAAALQSDLEDSLYKAAGGGGPLYGDGYGFRLPPSSPQKLADVAAPPGGP
PPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPG
ERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEKIEGSNGAA
TPSAPCGSGGRSSGATPVSGPPPPSASSTPAGQPTAVSRLQMQLHLRGLQNSASDLRGQL
QQLRKLQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEEL
ITQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKALVLKQLGETLTELKAHFPGLQSKMR
VVLRVEVEAVKFLKEEPQRLDGLLKRCRGVTDTLAQIRRQVDEGVWPPPNNLLSQSPKKV
TAETDFNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVDKAVSV
EAAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKAHPGPAPTPDHKPPK
APHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVV
VTSKKDSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAE
LESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSKHGKQRAEYMRIQAQQQATKPSKEMS
GSNETSSPVSEKPSASRTSIPVLTSFGARNSSISF
|
External Links |
GenBank ID Protein
| 115334682 |
UniProtKB/Swiss-Prot ID
| Q9C0H9 |
UniProtKB/Swiss-Prot Entry Name
| SRCN1_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| Not Available |
GeneCard ID
| SRCIN1 |
GenAtlas ID
| SRCIN1 |
HGNC ID
| HGNC:29506 |
References |
General References
| Not Available |