Cannabis Compound Database: Showing Protein Sodium/hydrogen exchanger 6 (CDBP03212)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP03212

Secondary Accession Numbers

Not Available

Name

Sodium/hydrogen exchanger 6

Description

Not Available

Synonyms

NHE-6
Na(+)/H(+) exchanger 6
Solute carrier family 9 member 6

Gene Name

SLC9A6

Protein Type

Transporter

Biological Properties

General Function

Involved in solute:hydrogen antiporter activity

Specific Function

Electroneutral exchange of protons for Na(+) and K(+) across the early and recycling endosome membranes. Contributes to calcium homeostasis

GO Classification

Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
transporter activity
monovalent cation:hydrogen antiporter activity
sodium:hydrogen antiporter activity
solute:cation antiporter activity
solute:hydrogen antiporter activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
cation transmembrane transporter activity
inorganic cation transmembrane transporter activity
monovalent inorganic cation transmembrane transporter activity
hydrogen ion transmembrane transporter activity
Process
cation homeostasis
monovalent inorganic cation homeostasis
regulation of ph
sodium ion transport
establishment of localization
transport
biological regulation
transmembrane transport
monovalent inorganic cation transport
ion transport
cation transport
regulation of biological quality
homeostatic process
chemical homeostasis
ion homeostasis

Cellular Location

Endosome membrane
Multi-pass membrane protein

Pathways

Not Available

Gene Properties

Chromosome Location

Not Available

Locus

Not Available

SNPs

SLC9A6

Gene Sequence

>2010 bp
ATGGCTCGGCGCGGCTGGCGGCGGGCACCCCTCCGCCGTGGCGTCGGCAGCAGTCCCCGA
GCCCGCAGGCTCATGCGGCCCCTTTGGTTGCTCCTCGCAGTGGGCGTCTTTGACTGGGCA
GGGGCTTCGGACGGCGGCGGCGGAGAGGCTAGAGCCATGGACGAGGAGATCGTGTCCGAG
AAGCAAGCCGAGGAGAGCCACCGGCAGGACAGCGCCAACCTGCTCATCTTCATCCTGCTG
CTCACCCTCACCATTCTCACAATCTGGCTCTTCAAGCACCGCCGGGCCCGCTTCCTGCAC
GAAACCGGCCTGGCTATGATTTATGGTCTTTTGGTGGGCCTTGTGCTTCGGTATGGCATT
CATGTTCCGAGTGATGTAAATAATGTGACCCTGAGCTGTGAAGTGCAGTCAAGTCCAACT
ACCTTACTGGTTACTTTTGATCCAGAAGTATTTTTCAACATATTACTTCCTCCTATCATA
TTTTATGCAGGTTATAGCCTGAAAAGGAGACATTTTTTTCGAAATCTTGGGTCTATCCTA
GCATACGCTTTTCTTGGAACAGCAATTTCTTGTTTCGTTATTGGGTCAATAATGTATGGC
TGTGTAACGCTGATGAAGGTAACGGGACAACTTGCAGGAGATTTTTACTTTACAGATTGC
CTACTGTTTGGTGCCATTGTATCAGCAACTGATCCAGTGACTGTTCTTGCTATATTCCAC
GAGCTTCAAGTTGATGTTGAACTCTATGCACTTCTTTTTGGTGAAAGTGTCCTCAATGAT
GCTGTTGCCATAGTGCTGTCCTCCTCAATAGTGGCATACCAGCCAGCTGGAGACAACAGT
CACACCTTTGATGTCACAGCGATGTTCAAGTCTATTGGGATCTTCCTTGGAATCTTCAGT
GGATCTTTTGCAATGGGTGCTGCTACTGGAGTGGTGACAGCTTTAGTGACAAAGTTCACC
AAATTACGGGAGTTCCAGTTGTTGGAGACAGGCCTGTTCTTCTTGATGTCCTGGAGTACC
TTCCTCTTGGCTGAAGCATGGGGCTTCACAGGTGTAGTTGCAGTATTGTTTTGTGGCATC
ACACAAGCACATTATACGTATAATAATTTGTCCACGGAGTCTCAGCATAGAACTAAACAG
TTGTTTGAGCTTCTCAATTTCTTGGCAGAGAATTTCATCTTCTCCTACATGGGGCTGACA
CTGTTCACCTTCCAGAACCATGTCTTTAACCCAACATTTGTAGTAGGAGCATTTGTTGCT
ATTTTCTTGGGAAGAGCTGCCAATATTTACCCCTTGTCCCTCTTACTTAATTTGGGTAGA
AGAAGTAAGATTGGATCAAATTTTCAACACATGATGATGTTTGCTGGCCTTCGTGGTGCA
ATGGCATTTGCCTTGGCCATTCGAGATACTGCCACTTATGCACGGCAAATGATGTTCAGC
ACCACGCTTCTGATTGTGTTTTTTACCGTGTGGGTATTTGGTGGTGGCACCACTGCAATG
CTGTCATGCTTGCATATCAGGGTTGGTGTTGATTCAGACCAAGAACACTTGGGTGTTCCT
GAAAATGAAAGGAGAACTACCAAAGCAGAGAGTGCTTGGCTTTTCCGGATGTGGTACAAC
TTTGATCATAACTATCTGAAGCCTCTGCTGACCCACAGCGGGCCTCCGCTGACAACAACA
CTCCCTGCCTGCTGTGGACCCATCGCCAGGTGCCTCACCAGCCCCCAGGCTTACGAAAAC
CAGGAACAGTTGAAAGATGATGATTCTGATCTTATTCTCAATGATGGTGACATCAGTTTG
ACATATGGAGATTCTACTGTGAACACTGAACCGGCCACATCCAGCGCCCCAAGGAGATTT
ATGGGAAACAGTTCTGAAGATGCCTTGGATCGGGAGCTTGCATTTGGGGACCATGAACTG
GTCATTCGAGGAACACGCCTGGTTCTTCCAATGGATGATTCTGAACCCCCGCTAAATTTG
TTAGATAATACGAGACATGGTCCAGCCTAA

Protein Properties

Number of Residues

669

Molecular Weight

74160.8

Theoretical pI

6.46

Pfam Domain Function

Na_H_Exchanger (PF00999 )

Signals

["None"]

Transmembrane Regions

["28-48", "71-91", "103-123", "142-162", "179-199", "220-240", "246-266", "292-312", "340-360", "382-402", "404-424", "447-467", "483-503"]

Protein Sequence

>Sodium/hydrogen exchanger 6
MARRGWRRAPLRRGVGSSPRARRLMRPLWLLLAVGVFDWAGASDGGGGEARAMDEEIVSE
KQAEESHRQDSANLLIFILLLTLTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGI
HVPSDVNNVTLSCEVQSSPTTLLVTFDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSIL
AYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSATDPVTVLAIFH
ELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFS
GSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGI
TQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFNPTFVVGAFVA
IFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDTATYARQMMFS
TTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPENERRTTKAESAWLFRMWYN
FDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSDLILNDGDISL
TYGDSTVNTEPATSSAPRRFMGNSSEDALDRELAFGDHELVIRGTRLVLPMDDSEPPLNL
LDNTRHGPA

External Links

GenBank ID Protein

2944233

UniProtKB/Swiss-Prot ID

Q92581

UniProtKB/Swiss-Prot Entry Name

SL9A6_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF030409

GeneCard ID