| Identification |
|---|
| HMDB Protein ID
| CDBP03210 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protein SET |
| Description
| Not Available |
| Synonyms
|
- HLA-DR-associated protein II
- I-2PP2A
- IGAAD
- Inhibitor of granzyme A-activated DNase
- PHAPII
- Phosphatase 2A inhibitor I2PP2A
- TAF-I
- Template-activating factor I
|
| Gene Name
| SET |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in nucleosome assembly |
| Specific Function
| Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone binding. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA- activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher |
| GO Classification
|
| Component |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| nucleus |
| organelle |
| Process |
| cellular process |
| cellular component organization at cellular level |
| organelle organization |
| chromosome organization |
| chromatin organization |
| nucleosome assembly |
| nucleosome organization |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
- Endoplasmic reticulum
- cytosol
- nucleoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:9 |
| Locus
| 9q34 |
| SNPs
| SET |
| Gene Sequence
|
>873 bp
ATGGCCCCTAAACGCCAGTCTCCACTCCCGCCTCAAAAGAAGAAACCAAGACCACCTCCT
GCTCTGGGACCGGAGGAGACATCGGCCTCTGCAGGCTTGCCGAAGAAGGGAGAAAAAGAA
CAGCAAGAAGCGATTGAACACATTGATGAAGTACAAAATGAAATAGACAGACTTAATGAA
CAAGCCAGTGAGGAGATTTTGAAAGTAGAACAGAAATATAACAAACTCCGCCAACCATTT
TTTCAGAAGAGGTCAGAATTGATCGCCAAAATCCCAAATTTTTGGGTAACAACATTTGTC
AACCATCCACAAGTGTCTGCACTGCTTGGGGAGGAAGATGAAGAGGCACTGCATTATTTG
ACCAGAGTTGAAGTGACAGAATTTGAAGATATTAAATCAGGTTACAGAATAGATTTTTAT
TTTGATGAAAATCCTTACTTTGAAAATAAAGTTCTCTCCAAAGAATTTCATCTGAATGAG
AGTGGTGATCCATCTTCGAAGTCCACCGAAATCAAATGGAAATCTGGAAAGGATTTGACG
AAACGTTCGAGTCAAACGCAGAATAAAGCCAGCAGGAAGAGGCAGCATGAGGAACCAGAG
AGCTTCTTTACCTGGTTTACTGACCATTCTGATGCAGGTGCTGATGAGTTAGGAGAGGTC
ATCAAAGATGATATTTGGCCAAACCCATTACAGTACTACTTGGTTCCCGATATGGATGAT
GAAGAAGGAGAAGGAGAAGAAGATGATGATGATGATGAAGAGGAGGAAGGATTAGAAGAT
ATTGACGAAGAAGGGGATGAGGATGAAGGTGAAGAAGATGAAGATGATGATGAAGGGGAG
GAAGGAGAGGAGGATGAAGGAGAAGATGACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 290 |
| Molecular Weight
| 33488.6 |
| Theoretical pI
| 3.95 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Protein SET
MAPKRQSPLPPQKKKPRPPPALGPEETSASAGLPKKGEKEQQEAIEHIDEVQNEIDRLNE
QASEEILKVEQKYNKLRQPFFQKRSELIAKIPNFWVTTFVNHPQVSALLGEEDEEALHYL
TRVEVTEFEDIKSGYRIDFYFDENPYFENKVLSKEFHLNESGDPSSKSTEIKWKSGKDLT
KRSSQTQNKASRKRQHEEPESFFTWFTDHSDAGADELGEVIKDDIWPNPLQYYLVPDMDD
EEGEGEEDDDDDEEEEGLEDIDEEGDEDEGEEDEDDDEGEEGEEDEGEDD
|
| External Links |
|---|
| GenBank ID Protein
| 170763500 |
| UniProtKB/Swiss-Prot ID
| Q01105 |
| UniProtKB/Swiss-Prot Entry Name
| SET_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001122821.1 |
| GeneCard ID
| SET |
| GenAtlas ID
| SET |
| HGNC ID
| HGNC:10760 |
| References |
|---|
| General References
| Not Available |