Identification
HMDB Protein ID CDBP03201
Secondary Accession Numbers Not Available
Name Sodium- and chloride-dependent transporter XTRP3
Description Not Available
Synonyms
  1. Sodium/imino-acid transporter 1
  2. Solute carrier family 6 member 20
  3. Transporter rB21A homolog
Gene Name SLC6A20
Protein Type Transporter
Biological Properties
General Function Involved in neurotransmitter:sodium symporter activity
Specific Function Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N- methylated amino acids
GO Classification
Component
integral to plasma membrane
membrane
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
neurotransmitter transporter activity
neurotransmitter:sodium symporter activity
transmembrane transporter activity
transporter activity
Process
establishment of localization
transport
neurotransmitter transport
Cellular Location
  1. Multi-pass membrane protein
  2. Apical cell membrane
Pathways
Gene Properties
Chromosome Location Chromosome:3
Locus 3p21.3
SNPs SLC6A20
Gene Sequence
>1779 bp
ATGGAGAAAGCGCGGCCGCTGTGGGCCAACTCGCTACAGTTCGTGTTCGCCTGCATCTCG
TACGCCGTGGGCCTGGGCAACGTGTGGCGATTCCCGTACCTGTGCCAGATGTACGGCGGA
GGTAGTTTCCTGGTCCCCTACATCATCATGCTTATCGTGGAGGGAATGCCGCTCTTGTAC
CTGGAACTGGCTGTGGGGCAGCGCATGCGGCAGGGCAGCATCGGCGCCTGGAGGACCATC
AGCCCGTACCTCAGTGGTGTCGGGGTCGCCAGCGTGGTGGTCTCTTTCTTCCTCTCCATG
TACTACAACGTCATCAACGCCTGGGCCTTCTGGTACCTCTTCCACTCCTTCCAGGATCCC
CTGCCGTGGTCTGTCTGCCCACTGAATGGTAACCACACGGGCTACGATGAGGAGTGTGAG
AAGGCGTCCTCCACACAGTACTTCTGGTACAGGAAAACCCTCAATATCTCGCCGTCCCTC
CAGGAGAACGGGGGTGTGCAGTGGGAGCCGGCGCTGTGCCTCCTCCTGGCCTGGCTGGTG
GTGTACCTGTGCATCCTGCGTGGCACCGAGTCCACTGGCAAGGTGGTGTATTTCACGGCG
TCACTGCCCTATTGCGTGCTCATCATCTACCTCATCAGGGGCCTCACGCTCCACGGAGCC
ACCAATGGCCTCATGTACATGTTCACTCCCAAGATAGAGCAGCTGGCCAACCCCAAGGCC
TGGATCAATGCAGCCACCCAGATCTTCTTCTCACTTGGCCTGGGCTTCGGCAGCCTGATC
GCCTTCGCCAGCTACAATGAGCCATCCAACAACTGCCAGAAGCACGCCATCATCGTGTCC
CTCATCAACAGCTTCACCTCCATATTTGCCAGCATTGTCACCTTCTCCATCTATGGCTTC
AAGGCCACCTTCAATTATGAAAACTGCTTGAAGAAGGTGAGTCTGCTGCTGACCAACACT
TTTGACCTTGAAGATGGCTTTTTGACAGCCAGCAACCTGGAGCAGGTGAAGGGCTACCTC
GCATCTGCCTACCCAAGCAAATACAGCGAGATGTTCCCGCAAATCAAAAACTGCAGCTTG
GAATCGGAGCTAGACACGGCCGTCCAGGGCACTGGCCTGGCATTCATCGTCTACACAGAG
GCCATTAAAAACATGGAGGTGTCCCAGCTGTGGTCGGTGCTCTACTTCTTCATGCTGCTG
ATGCTGGGCATTGGGAGCATGCTGGGGAACACAGCGGCCATCCTCACCCCTCTGACAGAC
AGCAAGATCATCTCCAGCCACCTGCCCAAGGAGGCCATCTCAGGTCTGGTGTGCCTTGTC
AACTGTGCCATTGGCATGGTGTTCACGATGGAGGCTGGGAACTACTGGTTTGACATATTC
AACGACTACGCGGCCACACTGTCCCTGCTGCTCATCGTGCTGGTGGAGACGATTGCCGTG
TGCTACGTGTACGGGCTGAGGAGATTTGAAAGTGACCTTAAGGCCATGACCGGCCGAGCT
GTGAGCTGGTACTGGAAGGTGATGTGGGCTGGCGTAAGCCCACTGCTGATTGTCAGCCTC
TTTGTCTTCTACCTGAGCGACTACATCCTCACGGGGACCCTGAAGTATCAAGCCTGGGAC
GCCTCCCAGGGCCAGCTCGTGACCAAAGATTACCCGGCCTATGCACTGGCTGTCATCGGG
CTGCTTGTGGCCTCCTCCACCATGTGCATCCCCCTGGCGGCCCTGGGGACTTTTGTTCAG
CGTCGCCTCAAGAGGGGAGACGCAGACCCCGTGGCCTGA
Protein Properties
Number of Residues 592
Molecular Weight 65913.3
Theoretical pI 6.63
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["6-26", "43-63", "80-100", "166-186", "195-215", "242-262", "277-297", "390-410", "432-452", "466-486", "505-525", "555-575"]
Protein Sequence
>Sodium- and chloride-dependent transporter XTRP3
MEKARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLY
LELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDP
LPWSVCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLV
VYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKIEQLANPKA
WINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGF
KATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSL
ESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTD
SKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAV
CYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTGTLKYQAWD
ASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQRRLKRGDADPVA
GenBank ID Protein 11181770
UniProtKB/Swiss-Prot ID Q9NP91
UniProtKB/Swiss-Prot Entry Name S6A20_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_020208.3
GeneCard ID SLC6A20
GenAtlas ID SLC6A20
HGNC ID HGNC:30927
References
General References Not Available