Identification |
HMDB Protein ID
| CDBP03201 |
Secondary Accession Numbers
| Not Available |
Name
| Sodium- and chloride-dependent transporter XTRP3 |
Description
| Not Available |
Synonyms
|
- Sodium/imino-acid transporter 1
- Solute carrier family 6 member 20
- Transporter rB21A homolog
|
Gene Name
| SLC6A20 |
Protein Type
| Transporter |
Biological Properties |
General Function
| Involved in neurotransmitter:sodium symporter activity |
Specific Function
| Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N- methylated amino acids |
GO Classification
|
Component |
integral to plasma membrane |
membrane |
cell part |
membrane part |
intrinsic to membrane |
integral to membrane |
Function |
neurotransmitter transporter activity |
neurotransmitter:sodium symporter activity |
transmembrane transporter activity |
transporter activity |
Process |
establishment of localization |
transport |
neurotransmitter transport |
|
Cellular Location
|
- Multi-pass membrane protein
- Apical cell membrane
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Kidney Function | | Not Available | Glucose Transporter Defect (SGLT2) | | Not Available | Hartnup Disorder | | Not Available | Iminoglycinuria | | Not Available | Lysinuric Protein Intolerance | | Not Available |
|
Gene Properties |
Chromosome Location
| Chromosome:3 |
Locus
| 3p21.3 |
SNPs
| SLC6A20 |
Gene Sequence
|
>1779 bp
ATGGAGAAAGCGCGGCCGCTGTGGGCCAACTCGCTACAGTTCGTGTTCGCCTGCATCTCG
TACGCCGTGGGCCTGGGCAACGTGTGGCGATTCCCGTACCTGTGCCAGATGTACGGCGGA
GGTAGTTTCCTGGTCCCCTACATCATCATGCTTATCGTGGAGGGAATGCCGCTCTTGTAC
CTGGAACTGGCTGTGGGGCAGCGCATGCGGCAGGGCAGCATCGGCGCCTGGAGGACCATC
AGCCCGTACCTCAGTGGTGTCGGGGTCGCCAGCGTGGTGGTCTCTTTCTTCCTCTCCATG
TACTACAACGTCATCAACGCCTGGGCCTTCTGGTACCTCTTCCACTCCTTCCAGGATCCC
CTGCCGTGGTCTGTCTGCCCACTGAATGGTAACCACACGGGCTACGATGAGGAGTGTGAG
AAGGCGTCCTCCACACAGTACTTCTGGTACAGGAAAACCCTCAATATCTCGCCGTCCCTC
CAGGAGAACGGGGGTGTGCAGTGGGAGCCGGCGCTGTGCCTCCTCCTGGCCTGGCTGGTG
GTGTACCTGTGCATCCTGCGTGGCACCGAGTCCACTGGCAAGGTGGTGTATTTCACGGCG
TCACTGCCCTATTGCGTGCTCATCATCTACCTCATCAGGGGCCTCACGCTCCACGGAGCC
ACCAATGGCCTCATGTACATGTTCACTCCCAAGATAGAGCAGCTGGCCAACCCCAAGGCC
TGGATCAATGCAGCCACCCAGATCTTCTTCTCACTTGGCCTGGGCTTCGGCAGCCTGATC
GCCTTCGCCAGCTACAATGAGCCATCCAACAACTGCCAGAAGCACGCCATCATCGTGTCC
CTCATCAACAGCTTCACCTCCATATTTGCCAGCATTGTCACCTTCTCCATCTATGGCTTC
AAGGCCACCTTCAATTATGAAAACTGCTTGAAGAAGGTGAGTCTGCTGCTGACCAACACT
TTTGACCTTGAAGATGGCTTTTTGACAGCCAGCAACCTGGAGCAGGTGAAGGGCTACCTC
GCATCTGCCTACCCAAGCAAATACAGCGAGATGTTCCCGCAAATCAAAAACTGCAGCTTG
GAATCGGAGCTAGACACGGCCGTCCAGGGCACTGGCCTGGCATTCATCGTCTACACAGAG
GCCATTAAAAACATGGAGGTGTCCCAGCTGTGGTCGGTGCTCTACTTCTTCATGCTGCTG
ATGCTGGGCATTGGGAGCATGCTGGGGAACACAGCGGCCATCCTCACCCCTCTGACAGAC
AGCAAGATCATCTCCAGCCACCTGCCCAAGGAGGCCATCTCAGGTCTGGTGTGCCTTGTC
AACTGTGCCATTGGCATGGTGTTCACGATGGAGGCTGGGAACTACTGGTTTGACATATTC
AACGACTACGCGGCCACACTGTCCCTGCTGCTCATCGTGCTGGTGGAGACGATTGCCGTG
TGCTACGTGTACGGGCTGAGGAGATTTGAAAGTGACCTTAAGGCCATGACCGGCCGAGCT
GTGAGCTGGTACTGGAAGGTGATGTGGGCTGGCGTAAGCCCACTGCTGATTGTCAGCCTC
TTTGTCTTCTACCTGAGCGACTACATCCTCACGGGGACCCTGAAGTATCAAGCCTGGGAC
GCCTCCCAGGGCCAGCTCGTGACCAAAGATTACCCGGCCTATGCACTGGCTGTCATCGGG
CTGCTTGTGGCCTCCTCCACCATGTGCATCCCCCTGGCGGCCCTGGGGACTTTTGTTCAG
CGTCGCCTCAAGAGGGGAGACGCAGACCCCGTGGCCTGA
|
Protein Properties |
Number of Residues
| 592 |
Molecular Weight
| 65913.3 |
Theoretical pI
| 6.63 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
- ["6-26", "43-63", "80-100", "166-186", "195-215", "242-262", "277-297", "390-410", "432-452", "466-486", "505-525", "555-575"]
|
Protein Sequence
|
>Sodium- and chloride-dependent transporter XTRP3
MEKARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLY
LELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDP
LPWSVCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLV
VYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKIEQLANPKA
WINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGF
KATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSL
ESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTD
SKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAV
CYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTGTLKYQAWD
ASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQRRLKRGDADPVA
|
External Links |
GenBank ID Protein
| 11181770 |
UniProtKB/Swiss-Prot ID
| Q9NP91 |
UniProtKB/Swiss-Prot Entry Name
| S6A20_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| NM_020208.3 |
GeneCard ID
| SLC6A20 |
GenAtlas ID
| SLC6A20 |
HGNC ID
| HGNC:30927 |
References |
General References
| Not Available |