| Identification |
|---|
| HMDB Protein ID
| CDBP03184 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ras-specific guanine nucleotide-releasing factor 2 |
| Description
| Not Available |
| Synonyms
|
- Ras guanine nucleotide exchange factor 2
- Ras-GRF2
|
| Gene Name
| RASGRF2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in Rho guanyl-nucleotide exchange factor activity |
| Specific Function
| Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| ras guanyl-nucleotide exchange factor activity |
| rho guanyl-nucleotide exchange factor activity |
| enzyme regulator activity |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| guanyl-nucleotide exchange factor activity |
| small gtpase regulator activity |
| Process |
| regulation of small gtpase mediated signal transduction |
| regulation of ras protein signal transduction |
| regulation of rho protein signal transduction |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| signal transduction |
| intracellular signal transduction |
| small gtpase mediated signal transduction |
| regulation of cell communication |
| regulation of signal transduction |
|
| Cellular Location
|
- Cell membrane
- Cytoplasm
- Peripheral membrane protein
- Peripheral membrane protein
- Endoplasmic reticulum membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q13 |
| SNPs
| RASGRF2 |
| Gene Sequence
|
>3711 bp
ATGCAGAAGAGCGTGCGCTACAACGAGGGGCACGCCCTGTACCTGGCCTTTCTGGCGCGC
AAGGAGGGCACCAAGCGCGGCTTCCTGAGTAAGAAGACGGCCGAGGCGAGCCGCTGGCAC
GAGAAGTGGTTCGCCCTCTACCAGAATGTGCTCTTCTACTTCGAGGGCGAGCAGAGCTGC
CGCCCGGCGGGCATGTACCTCCTGGAGGGCTGCAGCTGCGAACGAACGCCCGCGCCACCC
AGGGCCGGCGCCGGGCAGGGAGGCGTCCGAGACGCGCTGGACAAGCAGTATTACTTTACT
GTTCTTTTTGGCCATGAAGGTCAGAAGCCACTGGAGCTGCGCTGTGAGGAGGAGCAGGAT
GGTAAAGAGTGGATGGAGGCCATTCACCAAGCCAGTTATGCAGACATTTTGATTGAGAGG
GAAGTATTAATGCAGAAGTACATTCATCTAGTTCAGATCGTAGAGACAGAAAAAATTGCA
GCTAACCAACTCCGACATCAACTTGAAGATCAAGACACAGAAATCGAAAGGCTTAAATCA
GAGATTATTGCTCTTAATAAAACCAAAGAACGAATGCGACCTTACCAAAGCAACCAAGAA
GACGAAGATCCAGACATCAAGAAGATTAAAAAGGTTCAGAGCTTCATGCGAGGATGGTTG
TGCAGAAGGAAATGGAAGACCATCGTGCAGGATTACATTTGTTCTCCTCATGCTGAAAGT
ATGAGGAAGAGAAACCAGATTGTGTTCACCATGGTGGAGGCAGAGTCAGAGTACGTTCAC
CAGCTCTACATCCTGGTCAATGGCTTTCTCCGGCCCCTGCGTATGGCCGCCAGCTCCAAG
AAGCCCCCCATCAGCCACGACGACGTCAGCAGTATTTTTCTTAACAGTGAAACAATCATG
TTTCTTCATGAAATATTTCATCAAGGACTAAAGGCAAGGATAGCAAACTGGCCCACTTTA
ATTTTAGCTGATCTGTTTGATATTTTGCTCCCCATGCTGAACATTTATCAAGAATTTGTG
CGTAATCACCAGTACAGCCTGCAAGTTCTCGCCAATTGTAAGCAAAACAGAGATTTTGAC
AAACTCTTAAAACAGTATGAAGCCAATCCAGCCTGTGAGGGGAGGATGCTGGAGACATTC
TTGACCTATCCCATGTTCCAGATCCCCAGATATATCATCACACTCCATGAGCTCCTTGCT
CACACACCCCATGAGCATGTGGAAAGGAAAAGCCTGGAGTTTGCCAAATCAAAGCTAGAG
GAACTATCCAGAGTAATGCACGATGAAGTCAGCGACACTGAAAACATAAGGAAAAACCTT
GCCATCGAAAGAATGATCGTGGAGGGCTGTGACATCTTGCTGGACACCAGCCAAACGTTC
ATCCGCCAAGGTTCTCTTATTCAAGTACCTTCCGTTGAGAGGGGGAAACTTAGTAAAGTT
CGCCTGGGTTCGTTGTCTTTGAAAAAGGAAGGAGAGAGACAATGCTTCTTATTTACAAAA
CACTTTTTAATATGTACAAGAAGTTCAGGAGGGAAGCTTCATCTGCTCAAGACAGGTGGG
GTTCTGTCTCTAATAGACTGCACATTGATTGAGGAGCCAGATGCAAGCGATGATGACTCT
AAAGGTTCTGGGCAAGTGTTTGGGCACCTGGATTTTAAAATAGTGGTGGAGCCTCCTGAC
CGTGCCGCCTTCACTGTTGTCTTGTTAGCACCCTCACGCCAGGAGAAAGCTGCCTGGATG
AGTGACATCAGTCAGTGTGTGGACAATATACGATGTAATGGTTTAATGACTATAGTGTTT
GAAGAGAATTCCAAAGTCACTGTGCCACATATGATTAAGTCTGATGCCCGTCTTCATAAA
GACGACACTGACATTTGCTTCAGTAAAACACTCAACTCCTGCAAAGTGCCCCAGATCCGT
TATGCCAGCGTGGAGCGCCTCTTGGAACGACTGACAGACTTGCGGTTTCTTAGTATTGAT
TTCCTCAACACCTTTCTGCACACCTATCGTATTTTCACTACTGCCGCTGTGGTGCTGGGG
AAACTCTCCGACATATACAAGAGGCCTTTCACCTCCATCCCTGTCAGGTCATTGGAATTG
TTTTTTGCTACCAGCCAGAACAACAGAGGTGAACATTTGGTGGATGGCAAATCCCCACGT
CTGTGTCGCAAATTCTCTTCCCCGCCACCACTGGCTGTGTCCAGAACATCTTCCCCAGTG
AGGGCCAGAAAGCTGTCTTTGACTTCTCCCTTGAACTCAAAGATAGGAGCATTGGACCTG
ACAACTTCCAGCAGTCCCACCACCACCACCCAGAGTCCCGCTGCGTCTCCACCACCACAC
ACTGGTCAGATACCACTGGATCTCAGCAGAGGCCTCTCTTCTCCAGAGCAAAGCCCGGGA
ACGGTAGAAGAGAATGTCGATAACCCACGCGTGGATCTGTGTAACAAGCTAAAACGAAGT
ATTCAAAAAGCAGTCCTAGAGTCTGCACCAGCGGACCGAGCAGGAGTGGAAAGCTCCCCT
GCAGCGGACACCACAGAACTTTCACCTTGCAGATCCCCCTCAACTCCTCGGCACCTCCGC
TATCGACAGCCTGGAGGACAGACGGCGGACAATGCCCACTGCTCTGTTTCACCGGCTTCT
GCTTTTGCAATAGCCACAGCTGCAGCAGGACATGGGAGTCCACCAGGCTTTAACAACACC
GAGAGAACATGTGATAAAGAGTTTATTATACGGAGAACGGCTACCAATCGAGTTCTGAAC
GTCCTCCGTCACTGGGTCTCAAAGCACGCACAGGATTTCGAACTCAACAATGAACTAAAG
ATGAATGTCCTAAATTTGCTAGAAGAAGTTTTGCGAGACCCAGACCTTCTTCCCCAAGAA
AGGAAAGCCGCCGCGAATATCCTCAGGGCCCTTTCACAAGATGACCAAGATGACATCCAC
CTAAAATTAGAGGATATAATTCAAATGACTGACTGCATGAAGGCCGAATGCTTTGAGTCC
TTGTCGGCCATGGAGCTGGCAGAACAGATCACCCTCCTGGACCATGTCATTTTCAGAAGC
ATTCCCTACGAGGAGTTTCTTGGGCAGGGGTGGATGAAGCTGGATAAAAACGAAAGAACT
CCTTACATTATGAAAACCAGCCAACACTTCAATGACATGAGTAACCTGGTGGCCTCCCAG
ATAATGAACTATGCTGATGTCAGCTCCCGTGCCAACGCCATCGAGAAATGGGTGGCAGTG
GCGGACATCTGCCGATGCCTGCACAACTACAACGGCGTGCTGGAGATCACCTCGGCCTTA
AACAGAAGTGCCATCTACAGGCTGAAGAAAACCTGGGCCAAGGTCTCTAAGCAGACAAAA
GCTCTAATGGACAAACTTCAAAAGACTGTTTCCTCTGAAGGAAGATTTAAAAATCTTAGA
GAAACCCTTAAAAATTGTAACCCTCCTGCAGTTCCTTATCTTGGGATGTACTTGACAGAC
CTGGCATTTATTGAAGAAGGAACACCAAACTTTACTGAGGAAGGCCTTGTCAATTTCTCC
AAAATGAGAATGATATCACACATCATCAGAGAGATACGCCAGTTCCAGCAGACTTCCTAC
AGAATAGATCATCAGCCAAAGGTCGCACAGTACTTGCTTGACAAAGACCTTATCATAGAT
GAAGATACGCTATATGAGCTGTCACTCAAAATTGAACCTCGACTCCCTGCT
|
| Protein Properties |
|---|
| Number of Residues
| 1237 |
| Molecular Weight
| 140762.8 |
| Theoretical pI
| 7.56 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ras-specific guanine nucleotide-releasing factor 2
MQKSVRYNEGHALYLAFLARKEGTKRGFLSKKTAEASRWHEKWFALYQNVLFYFEGEQSC
RPAGMYLLEGCSCERTPAPPRAGAGQGGVRDALDKQYYFTVLFGHEGQKPLELRCEEEQD
GKEWMEAIHQASYADILIEREVLMQKYIHLVQIVETEKIAANQLRHQLEDQDTEIERLKS
EIIALNKTKERMRPYQSNQEDEDPDIKKIKKVQSFMRGWLCRRKWKTIVQDYICSPHAES
MRKRNQIVFTMVEAESEYVHQLYILVNGFLRPLRMAASSKKPPISHDDVSSIFLNSETIM
FLHEIFHQGLKARIANWPTLILADLFDILLPMLNIYQEFVRNHQYSLQVLANCKQNRDFD
KLLKQYEANPACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAKSKLE
ELSRVMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFIRQGSLIQVPSVERGKLSKV
RLGSLSLKKEGERQCFLFTKHFLICTRSSGGKLHLLKTGGVLSLIDCTLIEEPDASDDDS
KGSGQVFGHLDFKIVVEPPDAAAFTVVLLAPSRQEKAAWMSDISQCVDNIRCNGLMTIVF
EENSKVTVPHMIKSDARLHKDDTDICFSKTLNSCKVPQIRYASVERLLERLTDLRFLSID
FLNTFLHTYRIFTTAAVVLGKLSDIYKRPFTSIPVRSLELFFATSQNNRGEHLVDGKSPR
LCRKFSSPPPLAVSRTSSPVRARKLSLTSPLNSKIGALDLTTSSSPTTTTQSPAASPPPH
TGQIPLDLSRGLSSPEQSPGTVEENVDNPRVDLCNKLKRSIQKAVLESAPADRAGVESSP
AADTTELSPCRSPSTPRHLRYRQPGGQTADNAHCSVSPASAFAIATAAAGHGSPPGFNNT
ERTCDKEFIIRRTATNRVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQE
RKAAANILRALSQDDQDDIHLKLEDIIQMTDCMKAECFESLSAMELAEQITLLDHVIFRS
IPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIEKWVAV
ADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLR
ETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTSY
RIDHQPKVAQYLLDKDLIIDEDTLYELSLKIEPRLPA
|
| External Links |
|---|
| GenBank ID Protein
| 2522208 |
| UniProtKB/Swiss-Prot ID
| O14827 |
| UniProtKB/Swiss-Prot Entry Name
| RGRF2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF023130 |
| GeneCard ID
| RASGRF2 |
| GenAtlas ID
| RASGRF2 |
| HGNC ID
| HGNC:9876 |
| References |
|---|
| General References
| Not Available |