| Identification |
|---|
| HMDB Protein ID
| CDBP03183 |
| Secondary Accession Numbers
| Not Available |
| Name
| Regucalcin |
| Description
| Not Available |
| Synonyms
|
- RC
- SMP-30
- Senescence marker protein 30
- Gluconolactonase
- GNL
|
| Gene Name
| RGN |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).
|
| GO Classification
|
| Biological Process |
| positive regulation of ATPase activity |
| cellular calcium ion homeostasis |
| regulation of calcium-mediated signaling |
| Cellular Component |
| cytoplasm |
| nucleus |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| enzyme regulator activity |
| calcium ion binding |
| Molecular Function |
| zinc ion binding |
| calcium ion binding |
| enzyme regulator activity |
| gluconolactonase activity |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Ascorbate and aldarate metabolism | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| X |
| Locus
| Xp11.3 |
| SNPs
| RGN |
| Gene Sequence
|
>900 bp
ATGTCTTCCATTAAGATTGAGTGTGTTTTGCCAGAGAACTGCCGGTGTGGTGAGTCTCCA
GTATGGGAGGAAGTGTCCAACTCTCTGCTCTTTGTAGACATTCCTGCAAAAAAGGTTTGC
CGGTGGGATTCATTCACCAAGCAAGTACAGCGAGTGACCATGGATGCCCCAGTCAGCTCC
GTGGCTCTTCGCCAGTCGGGAGGCTATGTTGCCACCATTGGAACAAAGTTCTGTGCTTTG
AACTGGAAAGAACAATCAGCAGTTGTCTTGGCCACGGTGGATAACGACAAGAAAAACAAT
CGCTTCAATGATGGGAAGGTGGATCCCGCCGGGAGGTACTTTGCTGGCACCATGGCTGAG
GAAACAGCTCCAGCAGTTCTTGAGCGGCACCAGGGGGCCCTGTACTCCCTCTTTCCTGAT
CACCACGTGAAAAAGTACTTTGACCAGGTGGACATTTCCAATGGTTTGGATTGGTCGCTA
GACCACAAAATCTTCTATTACATTGACAGCCTGTCCTACTCCGTGGATGCCTTTGACTAT
GACCTGCAGACAGGACAGATCTCCAACCGCAGAAGTGTTTACAAGCTAGAAAAGGAAGAA
CAAATCCCAGATGGAATGTGTATTGATGCTGAGGGGAAGCTCTGGGTGGCCTGTTACAAT
GGAGGAAGAGTGATTCGTTTAGATCCTGTGACAGGGAAAAGACTTCAAACTGTGAAGTTG
CCTGTTGATAAAACAACTTCATGCTGCTTTGGAGGGAAGAATTACTCTGAAATGTATGTG
ACCTGCGCCCGGGATGGGATGGACCCCGAGGGTCTTTTGAGGCAACCTGAAGCTGGTGGA
ATTTTCAAGATAACTGGTCTGGGGGTCAAAGGAATTGCTCCCTACTCCTATGCGGGATGA
|
| Protein Properties |
|---|
| Number of Residues
| 299 |
| Molecular Weight
| 33252.53 |
| Theoretical pI
| 6.253 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Regucalcin
MSSIKIECVLPENCRCGESPVWEEVSNSLLFVDIPAKKVCRWDSFTKQVQRVTMDAPVSS
VALRQSGGYVATIGTKFCALNWKEQSAVVLATVDNDKKNNRFNDGKVDPAGRYFAGTMAE
ETAPAVLERHQGALYSLFPDHHVKKYFDQVDISNGLDWSLDHKIFYYIDSLSYSVDAFDY
DLQTGQISNRRSVYKLEKEEQIPDGMCIDAEGKLWVACYNGGRVIRLDPVTGKRLQTVKL
PVDKTTSCCFGGKNYSEMYVTCARDGMDPEGLLRQPEAGGIFKITGLGVKGIAPYSYAG
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q15493 |
| UniProtKB/Swiss-Prot Entry Name
| RGN_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| D31815 |
| GeneCard ID
| RGN |
| GenAtlas ID
| RGN |
| HGNC ID
| HGNC:9989 |
| References |
|---|
| General References
| Not Available |