Showing Protein Ras GTPase-activating protein 4 (CDBP03176)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP03176
Secondary Accession Numbers Not Available
Name Ras GTPase-activating protein 4
Description Not Available
Synonyms
  1. Calcium-promoted Ras inactivator
  2. Ras p21 protein activator 4
  3. RasGAP-activating-like protein 2
Gene Name RASA4
Protein Type Enzyme
Biological Properties
General Function Involved in GTPase activator activity
Specific Function Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis
GO Classification
Component
cell part
intracellular
Function
enzyme regulator activity
enzyme activator activity
gtpase activator activity
Process
signaling pathway
regulation of cell communication
regulation of signal transduction
regulation of small gtpase mediated signal transduction
biological regulation
regulation of biological process
regulation of cellular process
signal transduction
intracellular signaling pathway
signaling
Cellular Location
  1. Cell membrane
  2. Cytoplasm
  3. Peripheral membrane protein
  4. cytosol
Pathways
Gene Properties
Chromosome Location Chromosome:7
Locus 7q22
SNPs RASA4
Gene Sequence 
>2412 bp
ATGGCCAAGCGCAGCTCGCTGTACATCCGCATCGTGGAGGGGAAGAACCTTCCCGCCAAG
GACATCACTGGCAGCAGCGACCCCTACTGCATCGTGAAGGTGGACAATGAGCCCATCATC
AGGACAGCCACAGTGTGGAAGACCCTGTGCCCCTTCTGGGGTGAGGAGTACCAAGTGCAC
CTGCCGCCCACCTTCCACGCTGTGGCTTTCTATGTCATGGATGAGGATGCCCTCAGCCGG
GACGACGTTATCGGAAAGGTCTGCCTTACAAGGGACACCATAGCCTCTCACCCTAAGGGT
TTCAGCGGGTGGGCCCACCTGACGGAGGTCGACCCCGATGAGGAGGTGCAGGGCGAGATC
CACCTGCGGCTGGAAGTGTGGCCAGGGGCCCGGGCCTGCCGGCTACGCTGCTCTGTGCTG
GAGGCCAGGGATCTGGCCCCAAAGGACCGCAATGGCACATCTGACCCCTTCGTCCGAGTG
CGCTACAAGGGCCGGACACGGGAGACCTCGATCGTGAAGAAGTCATGCTACCCACGCTGG
AATGAGACGTTTGAATTTGAGCTGCAGGAGGGGGCCATGGAGGCGCTGTGCGTGGAGGCC
TGGGACTGGGACCTTGTCAGCCGAAACGACTTCCTGGGCAAAGTGGTGATTGATGTCCAG
AGACTGCGGGTGGTGCAGCAGGAGGAGGGCTGGTTCCGGCTGCAGCCCGACCAGTCCAAG
AGCCGGCGGCATGACGAGGGCAACCTGGGCTCCTTGCAGCTGGAGGTGCGGCTGCGGGAC
GAGACGGTGCTGCCCTCCAGCTACTACCAGCCACTGGTGCACCTGCTGTGCCACGAGGTC
AAGCTGGGCATGCAGGGCCCAGGGCAGCTGATCCCACTCATCGAGGAGACAACCAGCACC
GAGTGTCGCCAGGACGTGGCCACGAACCTGCTCAAGCTCTTCCTGGGGCAGGGGCTGGCC
AAGGACTTCCTGGACCTGCTCTTCCAGCTGGAGCTGAGTCGCACCAGTGAGACCAACACC
CTGTTCCGGAGCAACTCTCTGGCCTCAAAGTCCATGGAGTCTTTTCTGAAGGTGGCCGGG
ATGCAGTACCTGCACGGCGTCCTGGGCCCCATCATCAACAAGGTGTTTGAGGAGAAGAAG
TACGTGGAGCTGGACCCCAGCAAAGTGGAAGTTAAGGATGTAGGGTGCTCCGGGCTGCAC
CGCCCGCAGACCGAGGCCGAGGTGCTGGAGCAGAGCGCGCAGACGCTGCGCGCCCACCTG
GGGGCCCTGCTGAGCGCGCTCAGCCGCTCGGTTCGCGCGTGCCCCGCCGTGGTGCGCGCC
ACCTTCCGCCAGCTCTTCCGGCGCGTGCGCGAGCGCTTCCCCGGCGCCCAGCACGAGAAT
GTACCGTTCATCGCCGTCACCAGCTTCCTGTGCCTGCGCTTCTTCTCTCCCGCCATCATG
TCGCCCAAGCTCTTCCACCTGCGGGAGCGCCACGCGGACGCCCGCACCAGCCGCACCCTG
CTCCTGTTGGCCAAGGCAGTCCAGAACGTGGGCAACATGGACACGCCGGCTTCCAGGGCC
AAGGAGGCTTGGATGGAGCCGCTGCAGCCCACCGTGCGCCAGGGCGTGGCGCAGCTGAAG
GACTTCATCACCAAGCTCGTGGACATCGAGGAGAAGGACGAGCTGGACCTGCAGCGGACG
CTGAGTTTGCAGGCGCCACCTGTGAAGGAGGGGCCACTCTTCATCCACAGGACCAAGGGC
AAGGGCCCCCTCATGTCCTCCTCCTTCAAGAAGCTCTACTTCTCCCTCACTACCGAGGCC
CTCAGCTTCGCGAAGACGCCCAGCTCCAAGAAAAGCGCCCTCATCAAGTTAGCCAACATC
CGGGCAGCGGAAAAGGTTGAGGAAAAGAGCTTTGGCGGCTCGCACGTCATGCAGGTCATC
TACACGGACGACGCCGGCAGGCCCCAGACTGCCTACCTGCAGTGCAAGTGTGTGAATGAG
CTTAACCAGTGGCTGTCTGCGCTGCGGAAGGTGAGCATCAACAACACCGGACTGCTGGGC
TCCTACCACCCTGGCGTCTTCCGTGGGGACAAGTGGAGCTGCTGCCACCAAAAAGAGAAG
ACAGGTCAGGGCTGCGATAAGACCCGGTCACGGGTGACCCTGCAGGAGTGGAATGACCCT
CTTGACCATGACCTTGAGGCCCAGCTCATCTACCGGCACCTGCTGGGCGTGGAGGCCATG
CTGTGGGAGAGGCACCGGGAGCTGAGCGGGGGCGCAGAGGCAGGCACGGTGCCCACGAGC
CCTGGCAAAGTCCCCGAGGACTCATTGGCCCGGCTGCTCCGGGTGCTGCAGGACCTCCGC
GAGGCCCATAGCTCCAGCCCGGCCGGCTCCCCACCCTCAGAGCCCAACTGCCTCCTGGAG
CTGCAGACGTGA
Protein Properties
Number of Residues 803
Molecular Weight 90456.8
Theoretical pI 7.89
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Ras GTPase-activating protein 4
MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH
LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI
HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW
NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK
SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTST
ECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAG
MQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHL
GALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIM
SPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLK
DFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEA
LSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNE
LNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDP
LDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLR
EAHSSSPAGSPPSEPNCLLELQT
GenBank ID Protein 299829177
UniProtKB/Swiss-Prot ID O43374
UniProtKB/Swiss-Prot Entry Name RASL2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_006989.5
GeneCard ID RASA4
GenAtlas ID RASA4
HGNC ID HGNC:23181
References
General References Not Available