Identification
HMDB Protein ID CDBP03163
Secondary Accession Numbers Not Available
Name Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
Description Not Available
Synonyms
  1. CAM-PRP catalytic subunit
  2. Calmodulin-dependent calcineurin A subunit beta isoform
Gene Name PPP3CB
Protein Type Enzyme
Biological Properties
General Function Involved in hydrolase activity
Specific Function Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.
GO Classification
Biological Process
response to cytokine stimulus
axon extension
signal transduction
calcium ion-dependent exocytosis
muscle cell homeostasis
negative regulation of T cell mediated cytotoxicity
cellular response to drug
T cell proliferation
positive regulation of insulin secretion involved in cellular response to glucose stimulus
protein dephosphorylation
response to amphetamine
heart development
social behavior
memory
positive regulation of transcription, DNA-dependent
T cell differentiation
regulation of synaptic plasticity
protein phosphorylation
learning
T cell homeostasis
Cellular Component
cytosol
plasma membrane
calcineurin complex
Function
catalytic activity
hydrolase activity
Molecular Function
calcium ion binding
drug binding
calmodulin-dependent protein phosphatase activity
protein phosphatase 2B binding
calmodulin binding
Cellular Location
  1. Cytoplasmic
Pathways
Gene Properties
Chromosome Location 10
Locus 10q22.2
SNPs PPP3CB
Gene Sequence
>1575 bp
ATGGCCGCCCCGGAGCCGGCCCGGGCTGCACCGCCCCCACCCCCGCCCCCGCCGCCCCCT
CCCGGGGCTGACCGCGTCGTCAAAGCTGTCCCTTTCCCCCCAACACATCGCTTGACATCT
GAAGAAGTATTTGATTTGGATGGGATACCCAGGGTTGATGTTCTGAAGAACCACTTGGTG
AAAGAAGGTCGAGTAGATGAAGAAATTGCGCTTAGAATTATCAATGAGGGTGCTGCCATC
CTTCGGAGAGAGAAAACCATGATAGAAGTAGAAGCTCCAATCACAGTGTGTGGTGACATC
CATGGCCAATTTTTTGATCTGATGAAACTTTTTGAAGTAGGAGGATCACCTGCTAATACA
CGATACCTTTTTCTTGGCGATTATGTGGACAGAGGTTATTTTAGTATAGAGTGTGTCTTA
TATTTATGGGTTCTGAAGATTCTATACCCAAGCACATTATTTCTTCTGAGAGGCAACCAT
GAATGCAGACACCTTACTGAATATTTTACCTTTAAGCAGGAATGTAAAATTAAGTATTCG
GAAAGAGTCTATGAAGCTTGTATGGAAGCTTTTGATAGTTTGCCTCTTGCTGCACTTTTA
AACCAACAGTTTCTTTGTGTTCATGGTGGACTTTCACCAGAAATACACACACTGGATGAT
ATTAGGAGATTAGATAGATTCAAAGAGCCACCTGCATTTGGACCAATGTGTGACTTGTTA
TGGTCCGATCCTTCTGAAGATTTTGGAAATGAAAAATCACAGGAACATTTTAGTCACAAT
ACAGTTCGAGGATGTTCTTATTTTTATAACTATCCAGCAGTGTGTGAATTTTTGCAAAAC
AATAATTTGTTATCGATTATTAGAGCTCATGAAGCTCAAGATGCAGGCTATAGAATGTAC
AGAAAAAGTCAAACTACAGGGTTCCCTTCATTAATAACAATTTTTTCGGCACCTAATTAC
TTAGATGTCTACAATAATAAAGCTGCTGTATTAAAGTATGAAAATAATGTGATGAATATT
CGACAGTTTAACTGTTCTCCACATCCTTACTGGTTGCCTAATTTTATGGATGTCTTCACG
TGGTCTTTACCGTTTGTTGGAGAAAAAGTGACAGAAATGTTGGTAAATGTTCTGAGTATT
TGCTCTGATGATGAACTAATGACTGAAGGTGAAGACCAGTTTGATGGTTCAGCTGCAGCC
CGGAAAGAAATCATAAGAAACAAAATTCGAGCAATTGGCAAGATGGCAAGAGTCTTCTCT
GTTCTCAGGGAGGAGAGTGAAAGTGTGCTGACACTCAAGGGCCTGACTCCCACAGGGATG
TTGCCTAGTGGAGTGTTAGCTGGAGGACGGCAGACCCTGCAAAGTGCCACAGTTGAGGCT
ATTGAGGCTGAAAAAGCAATACGAGGATTCTCTCCACCACATAGAATCTGCAGTTTTGAA
GAGGCAAAGGGTTTGGATAGGATCAATGAGAGAATGCCACCTCGGAAAGATGCTGTACAG
CAAGATGGTTTCAATTCTCTGAACACCGCACATGCCACTGAGAACCACGGGACGGGCAAC
CATACTGCCCAGTGA
Protein Properties
Number of Residues 524
Molecular Weight 59122.87
Theoretical pI 5.903
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
MAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLV
KEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANT
RYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYS
ERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLL
WSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMY
RKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFT
WSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDGSAAARKEIIRNKIRAIGKMARVFS
VLREESESVLTLKGLTPTGMLPSGVLAGGRQTLQSATVEAIEAEKAIRGFSPPHRICSFE
EAKGLDRINERMPPRKDAVQQDGFNSLNTAHATENHGTGNHTAQ
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P16298
UniProtKB/Swiss-Prot Entry Name PP2BB_HUMAN
PDB IDs Not Available
GenBank Gene ID M29551
GeneCard ID PPP3CB
GenAtlas ID PPP3CB
HGNC ID HGNC:9315
References
General References Not Available