Cannabis Compound Database: Showing Protein Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (CDBP03162)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 compounds

Identification

HMDB Protein ID

CDBP03162

Secondary Accession Numbers

Not Available

Name

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

Description

Not Available

Synonyms

CAM-PRP catalytic subunit
Calmodulin-dependent calcineurin A subunit alpha isoform

Gene Name

PPP3CA

Protein Type

Enzyme

Biological Properties

General Function

Involved in hydrolase activity

Specific Function

Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.

GO Classification

Biological Process
G1/S transition of mitotic cell cycle
cellular response to glucose stimulus
response to amphetamine
calcium ion transport
negative regulation of insulin secretion
positive regulation of transcription from RNA polymerase II promoter
calcineurin-NFAT signaling cascade
protein import into nucleus
regulation of synaptic transmission
transition between fast and slow fiber
T cell activation
protein dephosphorylation
skeletal muscle fiber development
cellular response to drug
response to stress
regulation of excitatory postsynaptic membrane potential
response to calcium ion
Cellular Component
calcineurin complex
Z disc
cytosol
mitochondrion
nucleus
membrane
Function
catalytic activity
hydrolase activity
Molecular Function
enzyme binding
calcium ion binding
drug binding
calmodulin-dependent protein phosphatase activity
calmodulin binding

Cellular Location

Cytoplasmic
Nucleus

Pathways

Name	SMPDB/Pathwhiz	KEGG
MAPK signaling pathway	Not Available
Calcium signaling pathway	Not Available
Oocyte meiosis	Not Available
Apoptosis	Not Available
Wnt signaling pathway	Not Available

Gene Properties

Chromosome Location

Locus

4q24

SNPs

PPP3CA

Gene Sequence

>1566 bp
ATGTCCGAGCCCAAGGCAATTGATCCCAAGTTGTCGACGACCGACAGGGTGGTGAAAGCT
GTTCCATTTCCTCCAAGTCACCGGCTTACAGCAAAAGAAGTGTTTGATAATGATGGAAAA
CCTCGTGTGGATATCTTAAAGGCGCATCTTATGAAGGAGGGAAGGCTGGAAGAGAGTGTT
GCATTGAGAATAATAACAGAGGGTGCATCAATTCTTCGACAGGAAAAAAATTTGCTGGAT
ATTGATGCGCCAGTCACTGTTTGTGGGGACATTCATGGACAATTCTTTGATTTGATGAAG
CTCTTTGAAGTCGGGGGATCTCCTGCCAACACTCGCTACCTCTTCTTAGGGGACTATGTT
GACAGAGGGTACTTCAGTATTGAATGTGTGCTGTATTTGTGGGCCTTGAAAATTCTCTAC
CCCAAAACACTGTTTTTACTTCGTGGAAATCATGAATGTAGACATCTAACAGAGTATTTC
ACATTTAAACAAGAATGTAAAATAAAGTATTCAGAACGAGTATATGATGCCTGTATGGAT
GCCTTTGACTGCCTTCCCCTGGCTGCCCTGATGAACCAACAGTTCCTGTGTGTGCATGGT
GGTTTGTCTCCAGAGATTAACACTTTAGATGATATCAGAAAATTAGACCGATTCAAAGAA
CCACCTGCATATGGACCTATGTGTGATATCCTGTGGTCAGACCCCCTGGAAGATTTTGGA
AATGAGAAGACTCAGGAACATTTCACTCACAACACAGTCAGGGGGTGTTCATACTTCTAC
AGTTACCCGGCTGTATGTGAATTCTTACAGCACAATAACTTGTTATCTATACTCCGAGCC
CACGAAGCCCAAGATGCAGGGTACCGCATGTACAGGAAAAGCCAAACAACAGGCTTCCCT
TCTCTAATTACAATTTTTTCAGCACCAAATTACTTAGATGTATACAATAACAAAGCTGCA
GTATTGAAGTATGAGAACAATGTTATGAATATCAGGCAATTCAACTGTTCTCCTCATCCA
TACTGGCTTCCAAATTTCATGGATGTTTTTACTTGGTCCCTTCCATTTGTTGGGGAAAAA
GTGACTGAGATGCTGGTAAATGTCCTCAACATCTGCTCAGATGATGAACTAGGGTCAGAA
GAAGATGGATTTGATGGTGCAACAGCTGCAGCCCGGAAAGAGGTGATAAGGAACAAGATC
CGAGCAATAGGCAAAATGGCCAGAGTGTTCTCAGTGCTCAGAGAAGAGAGTGAGAGTGTG
CTGACGCTGAAAGGCTTGACCCCAACTGGCATGCTCCCCAGCGGAGTACTTTCTGGAGGG
AAGCAAACCCTGCAAAGCGCTACTGTTGAGGCTATTGAGGCTGATGAAGCTATCAAAGGA
TTTTCACCACAACATAAGATCACTAGCTTCGAGGAAGCCAAGGGCTTAGACCGAATTAAT
GAGAGGATGCCGCCTCGCAGAGATGCCATGCCCTCTGACGCCAACCTTAACTCCATCAAC
AAGGCTCTCACCTCAGAGACTAACGGCACGGACAGCAATGGCAGTAATAGCAGCAATATT
CAGTGA

Protein Properties

Number of Residues

521

Molecular Weight

58687.27

Theoretical pI

5.864

Pfam Domain Function

Metallophos (PF00149 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
MSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESV
ALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYV
DRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMD
AFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFG
NEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFP
SLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEK
VTEMLVNVLNICSDDELGSEEDGFDGATAAARKEVIRNKIRAIGKMARVFSVLREESESV
LTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEADEAIKGFSPQHKITSFEEAKGLDRIN
ERMPPRRDAMPSDANLNSINKALTSETNGTDSNGSNSSNIQ

External Links

GenBank ID Protein

306477

UniProtKB/Swiss-Prot ID

Q08209

UniProtKB/Swiss-Prot Entry Name

PP2BA_HUMAN

PDB IDs