| Identification |
|---|
| HMDB Protein ID
| CDBP03159 |
| Secondary Accession Numbers
| Not Available |
| Name
| Calcium-independent phospholipase A2-gamma |
| Description
| Not Available |
| Synonyms
|
- Intracellular membrane-associated calcium-independent phospholipase A2 gamma
- PNPLA-gamma
- Patatin-like phospholipase domain-containing protein 8
- iPLA2-2
- iPLA2-gamma
|
| Gene Name
| PNPLA8 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in metabolic process |
| Specific Function
| Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids.
|
| GO Classification
|
| Biological Process |
| phosphatidylethanolamine acyl-chain remodeling |
| phosphatidylcholine catabolic process |
| arachidonic acid secretion |
| phosphatidylethanolamine catabolic process |
| linoleic acid metabolic process |
| arachidonic acid metabolic process |
| glycerophospholipid biosynthetic process |
| prostaglandin biosynthetic process |
| cell death |
| phosphatidylcholine acyl-chain remodeling |
| Cellular Component |
| endoplasmic reticulum membrane |
| perinuclear region of cytoplasm |
| peroxisomal membrane |
| integral to membrane |
| Golgi membrane |
| Function |
| binding |
| Molecular Function |
| ATP binding |
| calcium-independent phospholipase A2 activity |
| lysophospholipase activity |
| Process |
| metabolic process |
| primary metabolic process |
| lipid metabolic process |
|
| Cellular Location
|
- Cytoplasm
- perinuclear region
- Golgi apparatus membrane
- Endoplasmic reticulum membrane
- Single-pass membrane protein
- Single-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| 7q31 |
| SNPs
| PNPLA8 |
| Gene Sequence
|
>2349 bp
ATGTCTATTAATCTGACTGTAGATATATATATTTACCTCCTTAGTAATGCAAGAAGTGTT
TGTGGGAAGCAGAGAAGCAAGCAACTGTATTTCTTGTTCTCACCTAAGCATTACTGGAGG
ATAAGCCACATCAGTCTACAAAGAGGTTTTCATACAAACATAATAAGATGTAAATGGACC
AAAAGTGAAGCACATTCTTGCAGTAAGCACTGTTACTCTCCAAGCAACCATGGTTTACAT
ATTGGGATTTTGAAACTTAGCACTTCTGCTCCCAAGGGACTTACAAAAGTGAACATTTGT
ATGTCCCGTATTAAAAGTACTTTGAACTCTGTTTCAAAGGCTGTTTTTGGCAATCAAAAT
GAAATGATTTCACGTTTAGCTCAATTTAAGCCAAGTTCCCAAATTTTAAGAAAAGTATCG
GATAGTGGCTGGTTAAAACAGAAAAACATCAAACAAGCCATCAAATCTCTGAAAAAATAT
AGTGACAAATCAGCAGAAAAGAGTCCTTTTCCAGAAGAGAAAAGTCACATTATAGACAAA
GAAGAAGATATAGGTAAACGCAGTCTTTTTCATTACACAAGTTCTATAACCACAAAATTT
GGAGACTCATTCTACTTTTTATCAAATCATATTAATTCATATTTCAAACGTAAGGAAAAA
ATGTCTCAACAAAAGGAAAATGAACATTTCCGGGACAAATCAGAACTTGAAGATAAAAAG
GTAGAAGAGGGGAAATTAAGATCTCCAGATCCTGGCATCCTGGCTTATAAGCCAGGCTCA
GAATCTGTACATACGGTGGACAAGCCTACAAGTCCTTCTGCGATACCTGATGTTCTTCAA
GTTTCAACTAAACAAAGTATTGCTAACTTTCTTTCTCGTCCCACGGAAGGTGTACAAGCT
TTAGTAGGTGGTTATATTGGTGGACTTGTCCCCAAATTAAAGTATGATTCAAAGAGTCAG
TCAGAAGAACAGGAAGAGCCTGCTAAAACTGATCAGGCTGTCAGCAAAGACAGAAATGCA
GAGGAGAAAAAGCGTTTATCTCTTCAGCGAGAAAAGATTATCGCAAGGGTGAGTATTGAT
AACAGGACCCGGGCATTAGTTCAGGCATTAAGAAGAACAACTGACCCAAAGCTCTGCATT
ACTAGGGTTGAAGAACTGACTTTTCATCTTCTAGAATTTCCTGAAGGAAAAGGAGTGGCT
GTCAAGGAAAGAATTATTCCATATTTATTACGACTGAGACAAATTAAGGATGAAACTCTT
CAGGCTGCAGTTAGAGAAATTTTGGCCCTAATTGGCTATGTGGATCCAGTGAAAGGGAGA
GGAATCCGAATTCTCTCAATTGATGGTGGAGGAACAAGGGGCGTGGTTGCTCTCCAGACC
CTACGAAAATTAGTTGAACTTACTCAGAAGCCAGTTCATCAGCTCTTTGATTACATTTGT
GGTGTAAGCACAGGTGCCATATTAGCTTTCATGTTGGGGTTGTTTCATATGCCCTTGGAT
GAATGTGAGGAACTTTATCGAAAATTAGGATCAGATGTATTTTCACAAAATGTCATTGTT
GGAACAGTAAAAATGAGTTGGAGCCATGCATTTTATGACAGTCAAACATGGGAAAACATT
CTTAAGGATAGGATGGGATCTGCACTGATGATTGAAACAGCAAGAAACCCCACATGTCCT
AAGGTAGCTGCTGTAAGTACCATAGTAAATAGAGGGATAACACCCAAAGCTTTTGTGTTC
AGAAACTATGGTCATTTTCCTGGAATCAACTCTCATTATTTGGGAGGCTGTCAGTATAAA
ATGTGGCAGGCCATTAGAGCCTCATCTGCTGCTCCAGGCTACTTTGCAGAATATGCATTG
GGAAATGATCTTCATCAAGATGGAGGTTTGCTTCTGAATAACCCTTCGGCATTAGCTATG
CATGAGTGTAAATGTCTTTGGCCAGATGTGCCGTTAGAGTGCATAGTATCCCTGGGCACT
GGACGTTATGAGAGTGATGTGAGAAACACGGTAACATACACAAGCTTGAAAACTAAACTT
TCTAATGTTATCAACAGTGCTACAGATACAGAAGAAGTCCATATAATGCTTGATGGCCTG
TTACCTCCTGACACCTATTTTAGATTCAATCCTGTAATGTGTGAAAACATACCTCTAGAT
GAAAGTCGAAATGAAAAGCTGGATCAGCTGCAGTTGGAAGGGTTGAAATACATAGAAAGA
AATGAACAAAAAATGAAAAAAGTTGCAAAAATATTAAGTCAAGAAAAAACAACTCTGCAG
AAAATTAATGATTGGATAAAATTAAAAACTGATATGTATGAAGGACTTCCATTCTTTTCA
AAATTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 782 |
| Molecular Weight
| 88476.085 |
| Theoretical pI
| 9.23 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Calcium-independent phospholipase A2-gamma
MSINLTVDIYIYLLSNARSVCGKQRSKQLYFLFSPKHYWRISHISLQRGFHTNIIRCKWT
KSEAHSCSKHCYSPSNHGLHIGILKLSTSAPKGLTKVNICMSRIKSTLNSVSKAVFGNQN
EMISRLAQFKPSSQILRKVSDSGWLKQKNIKQAIKSLKKYSDKSAEKSPFPEEKSHIIDK
EEDIGKRSLFHYTSSITTKFGDSFYFLSNHINSYFKRKEKMSQQKENEHFRDKSELEDKK
VEEGKLRSPDPGILAYKPGSESVHTVDKPTSPSAIPDVLQVSTKQSIANFLSRPTEGVQA
LVGGYIGGLVPKLKYDSKSQSEEQEEPAKTDQAVSKDRNAEEKKRLSLQREKIIARVSID
NRTRALVQALRRTTDPKLCITRVEELTFHLLEFPEGKGVAVKERIIPYLLRLRQIKDETL
QAAVREILALIGYVDPVKGRGIRILSIDGGGTRGVVALQTLRKLVELTQKPVHQLFDYIC
GVSTGAILAFMLGLFHMPLDECEELYRKLGSDVFSQNVIVGTVKMSWSHAFYDSQTWENI
LKDRMGSALMIETARNPTCPKVAAVSTIVNRGITPKAFVFRNYGHFPGINSHYLGGCQYK
MWQAIRASSAAPGYFAEYALGNDLHQDGGLLLNNPSALAMHECKCLWPDVPLECIVSLGT
GRYESDVRNTVTYTSLKTKLSNVINSATDTEEVHIMLDGLLPPDTYFRFNPVMCENIPLD
ESRNEKLDQLQLEGLKYIERNEQKMKKVAKILSQEKTTLQKINDWIKLKTDMYEGLPFFS
KL
|
| External Links |
|---|
| GenBank ID Protein
| 7670058 |
| UniProtKB/Swiss-Prot ID
| Q9NP80 |
| UniProtKB/Swiss-Prot Entry Name
| PLPL8_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB041261 |
| GeneCard ID
| PNPLA8 |
| GenAtlas ID
| PNPLA8 |
| HGNC ID
| HGNC:28900 |
| References |
|---|
| General References
| Not Available |