| Identification |
|---|
| HMDB Protein ID
| CDBP03158 |
| Secondary Accession Numbers
| Not Available |
| Name
| Prokineticin receptor 2 |
| Description
| Not Available |
| Synonyms
|
- G-protein coupled receptor 73-like 1
- GPR73b
- GPRg2
- PK-R2
|
| Gene Name
| PROKR2 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor protein signaling pathway |
| Specific Function
| Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| neuropeptide receptor activity |
| receptor activity |
| neuropeptide y receptor activity |
| molecular transducer activity |
| signal transducer activity |
| peptide receptor activity |
| peptide receptor activity, g-protein coupled |
| Process |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 20p12.3 |
| SNPs
| PROKR2 |
| Gene Sequence
|
>1155 bp
ATGGCAGCCCAGAATGGAAACACCAGTTTCACACCCAACTTTAATCCACCCCAAGACCAT
GCCTCCTCCCTCTCCTTTAACTTCAGTTATGGTGATTATGACCTCCCTATGGATGAGGAT
GAGGACATGACCAAGACCCGGACCTTCTTCGCAGCCAAGATCGTCATTGGCATTGCACTG
GCAGGCATCATGCTGGTCTGCGGCATCGGTAACTTTGTCTTTATCGCTGCCCTCACCCGC
TATAAGAAGTTGCGCAACCTCACCAATCTGCTCATTGCCAACCTGGCCATCTCCGACTTC
CTGGTGGCCATCATCTGCTGCCCCTTCGAGATGGACTACTACGTGGTACGGCAGCTCTCC
TGGGAGCATGGCCACGTGCTCTGTGCCTCCGTCAACTACCTGCGCACCGTCTCCCTCTAC
GTCTCCACCAATGCCTTGCTGGCCATTGCCATTGACAGATATCTCGCCATCGTTCACCCC
TTGAAACCACGGATGAATTATCAAACGGCCTCCTTCCTGATCGCCTTGGTCTGGATGGTG
TCCATTCTCATTGCCATCCCATCGGCTTACTTTGCAACAGAAACGGTCCTCTTTATTGTC
AAGAGCCAGGAGAAGATCTTCTGTGGCCAGATCTGGCCTGTGGATCAGCAGCTCTACTAC
AAGTCCTACTTCCTCTTCATCTTTGGTGTCGAGTTCGTGGGCCCTGTGGTCACCATGACC
CTGTGCTATGCCAGGATCTCCCGGGAGCTCTGGTTCAAGGCAGTCCCTGGGTTCCAGACG
GAGCAGATTCGCAAGCGGCTGCGCTGCCGCAGGAAGACGGTCCTGGTGCTCATGTGCATT
CTCACGGCCTATGTGCTGTGCTGGGCACCCTTCTACGGTTTCACCATCGTTCGTGACTTC
TTCCCCACTGTGTTCGTGAAGGAAAAGCACTACCTCACTGCCTTCTACGTGGTCGAGTGC
ATCGCCATGAGCAACAGCATGATCAACACCGTGTGCTTCGTGACGGTCAAGAACAACACC
ATGAAGTACTTCAAGAAGATGATGCTGCTGCACTGGCGTCCCTCCCAGCGGGGGAGCAAG
TCCAGTGCTGACCTTGACCTCAGAACCAACGGGGTGCCCACCACAGAAGAGGTGGACTGT
ATCAGGCTGAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 384 |
| Molecular Weight
| 43995.4 |
| Theoretical pI
| 8.94 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["55-75", "90-110", "137-157", "172-192", "224-244", "274-294", "314-334"]
|
| Protein Sequence
|
>Prokineticin receptor 2
MAAQNGNTSFTPNFNPPQDHASSLSFNFSYGDYDLPMDEDEDMTKTRTFFAAKIVIGIAL
AGIMLVCGIGNFVFIAALTRYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQLS
WEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLKPRMNYQTASFLIALVWMV
SILIAIPSAYFATETVLFIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGVEFVGPVVTMT
LCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDF
FPTVFVKEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTMKYFKKMMLLHWRPSQRGSK
SSADLDLRTNGVPTTEEVDCIRLK
|
| External Links |
|---|
| GenBank ID Protein
| 25006243 |
| UniProtKB/Swiss-Prot ID
| Q8NFJ6 |
| UniProtKB/Swiss-Prot Entry Name
| PKR2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB084081 |
| GeneCard ID
| PROKR2 |
| GenAtlas ID
| PROKR2 |
| HGNC ID
| HGNC:15836 |
| References |
|---|
| General References
| Not Available |