| Identification |
|---|
| HMDB Protein ID
| CDBP03156 |
| Secondary Accession Numbers
| Not Available |
| Name
| Polycystin-2 |
| Description
| Not Available |
| Synonyms
|
- Autosomal dominant polycystic kidney disease type II protein
- Polycystic kidney disease 2 protein
- Polycystwin
- R48321
|
| Gene Name
| PKD2 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein (Potential)
- Endoplasmic reticulum
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:4 |
| Locus
| 4q21-q23 |
| SNPs
| PKD2 |
| Gene Sequence
|
>2907 bp
ATGGTGAACTCCAGTCGCGTGCAGCCTCAGCAGCCCGGGGACGCCAAGCGGCCGCCCGCG
CCCCGCGCGCCGGACCCGGGCCGGCTGATGGCTGGCTGCGCGGCCGTGGGCGCCAGCCTC
GCCGCCCCGGGCCGCCTCTGCGAGCAGCGGGGCCTGGAGATCGAGATGCAGCGCATCCGG
CAGGCGGCCGCGCGGGACCCCCCGGCCGGAGCCGCGGCCTCCCCTTCTCCTCCGCTCTCG
TCGTGCTCCCGGCAGGCGTGGAGCCGCGATAACCCCGGCTTCGAGGCCGAGGAGGAGGAG
GAGGAGGTGGAAGGGGAAGAAGGCGGAATGGTGGTGGAGATGGACGTAGAGTGGCGCCCG
GGCAGCCGGAGGTCGGCCGCCTCCTCGGCCGTGAGCTCCGTGGGCGCGCGGAGCCGGGGG
CTTGGGGGCTACCACGGCGCGGGCCACCCGAGCGGGAGGCGGCGCCGGCGAGAGGACCAG
GGCCCGCCGTGCCCCAGCCCAGTCGGCGGCGGGGACCCGCTGCATCGCCACCTCCCCCTG
GAAGGGCAGCCGCCCCGAGTGGCCTGGGCGGAGAGGCTGGTTCGCGGGCTGCGAGGTCTC
TGGGGAACAAGACTCATGGAGGAAAGCAGCACTAACCGAGAGAAATACCTTAAAAGTGTT
TTACGGGAACTGGTCACATACCTCCTTTTTCTCATAGTCTTGTGCATCTTGACCTACGGC
ATGATGAGCTCCAATGTGTACTACTACACCCGGATGATGTCACAGCTCTTCCTAGACACC
CCCGTGTCCAAAACGGAGAAAACTAACTTTAAAACTCTGTCTTCCATGGAAGACTTCTGG
AAGTTCACAGAAGGCTCCTTATTGGATGGGCTGTACTGGAAGATGCAGCCCAGCAACCAG
ACTGAAGCTGACAACCGAAGTTTCATCTTCTATGAGAACCTGCTGTTAGGGGTTCCACGA
ATACGGCAACTCCGAGTCAGAAATGGATCCTGCTCTATCCCCCAGGACTTGAGAGATGAA
ATTAAAGAGTGCTATGATGTCTACTCTGTCAGTAGTGAAGATAGGGCTCCCTTTGGGCCC
CGAAATGGAACCGCTTGGATCTACACAAGTGAAAAAGACTTGAATGGTAGTAGCCACTGG
GGAATCATTGCAACTTATAGTGGAGCTGGCTATTATCTGGATTTGTCAAGAACAAGAGAG
GAAACAGCTGCACAAGTTGCTAGCCTCAAGAAAAATGTCTGGCTGGACCGAGGAACCAGG
GCAACTTTTATTGACTTCTCAGTGTACAACGCCAACATTAACCTGTTCTGTGTGGTCAGG
TTATTGGTTGAATTCCCAGCAACAGGTGGTGTGATTCCATCTTGGCAATTTCAGCCTTTA
AAGCTGATCCGATATGTCACAACTTTTGATTTCTTCCTGGCAGCCTGTGAGATTATCTTT
TGTTTCTTTATCTTTTACTATGTGGTGGAAGAGATATTGGAAATTCGCATTCACAAACTA
CACTATTTCAGGAGTTTCTGGAATTGTCTGGATGTTGTGATCGTTGTGCTGTCAGTGGTA
GCTATAGGAATTAACATATACAGAACATCAAATGTGGAGGTGCTACTACAGTTTCTGGAA
GATCAAAATACTTTCCCCAACTTTGAGCATCTGGCATATTGGCAGATACAGTTCAACAAT
ATAGCTGCTGTCACAGTATTTTTTGTCTGGATTAAGCTCTTCAAATTCATCAATTTTAAC
AGGACCATGAGCCAGCTCTCGACAACCATGTCTCGATGTGCCAAAGACCTGTTTGGCTTT
GCTATTATGTTCTTCATTATTTTCCTAGCGTATGCTCAGTTGGCATACCTTGTCTTTGGC
ACTCAGGTCGATGACTTCAGTACTTTCCAAGAGTGTATCTTCACTCAATTCCGTATCATT
TTGGGCGATATCAACTTTGCAGAGATTGAGGAAGCTAATCGAGTTTTGGGACCAATTTAT
TTCACTACATTTGTGTTCTTTATGTTCTTCATTCTTTTGAATATGTTTTTGGCTATCATC
AATGATACTTACTCTGAAGTGAAATCTGACTTGGCACAGCAGAAAGCTGAAATGGAACTC
TCAGATCTTATCAGAAAGGGCTACCATAAAGCTTTGGTCAAACTAAAACTGAAAAAAAAT
ACCGTGGATGACATTTCAGAGAGTCTGCGGCAAGGAGGAGGCAAGTTAAACTTTGACGAA
CTTCGACAAGATCTCAAAGGGAAGGGCCATACTGATGCAGAGATTGAGGCAATATTCACA
AAGTACGACCAAGATGGAGACCAAGAACTGACCGAACATGAACATCAGCAGATGAGAGAC
GACTTGGAGAAAGAGAGGGAGGACCTGGATTTGGATCACAGTTCTTTACCACGTCCCATG
AGCAGCCGAAGTTTCCCTCGAAGCCTGGATGACTCTGAGGAGGATGACGATGAAGATAGC
GGACATAGCTCCAGAAGGAGGGGAAGCATTTCTAGTGGCGTTTCTTACGAAGAGTTTCAA
GTCCTGGTGAGACGAGTGGACCGGATGGAGCATTCCATCGGCAGCATAGTGTCCAAGATT
GACGCCGTGATCGTGAAGCTAGAGATTATGGAGCGAGCCAAACTGAAGAGGAGGGAGGTG
CTGGGAAGGCTGTTGGATGGGGTGGCCGAGGATGAAAGGCTGGGTCGTGACAGTGAAATC
CATAGGGAACAGATGGAACGGCTAGTACGTGAAGAGTTGGAACGCTGGGAATCCGATGAT
GCAGCTTCCCAGATCAGTCATGGTTTAGGCACGCCAGTGGGACTAAATGGTCAACCTCGC
CCCAGAAGCTCCCGCCCATCTTCCTCCCAATCTACAGAAGGCATGGAAGGTGCAGGTGGA
AATGGGAGTTCTAATGTCCACGTATGA
|
| Protein Properties |
|---|
| Number of Residues
| 968 |
| Molecular Weight
| 109690.2 |
| Theoretical pI
| 5.41 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["224-244", "469-489", "506-526", "551-571", "599-619", "659-679"]
|
| Protein Sequence
|
>Polycystin-2
MVNSSRVQPQQPGDAKRPPAPRAPDPGRLMAGCAAVGASLAAPGGLCEQRGLEIEMQRIR
QAAARDPPAGAAASPSPPLSSCSRQAWSRDNPGFEAEEEEEEVEGEEGGMVVEMDVEWRP
GSRRSAASSAVSSVGARSRGLGGYHGAGHPSGRRRRREDQGPPCPSPVGGGDPLHRHLPL
EGQPPRVAWAERLVRGLRGLWGTRLMEESSTNREKYLKSVLRELVTYLLFLIVLCILTYG
MMSSNVYYYTRMMSQLFLDTPVSKTEKTNFKTLSSMEDFWKFTEGSLLDGLYWKMQPSNQ
TEADNRSFIFYENLLLGVPRIRQLRVRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGP
RNGTAWIYTSEKDLNGSSHWGIIATYSGAGYYLDLSRTREETAAQVASLKKNVWLDRGTR
ATFIDFSVYNANINLFCVVRLLVEFPATGGVIPSWQFQPLKLIRYVTTFDFFLAACEIIF
CFFIFYYVVEEILEIRIHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEVLLQFLE
DQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGF
AIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEIEEANRVLGPIY
FTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKAEMELSDLIRKGYHKALVKLKLKKN
TVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEHEHQQMRD
DLEKEREDLDLDHSSLPRPMSSRSFPRSLDDSEEDDDEDSGHSSRRRGSISSGVSYEEFQ
VLVRRVDRMEHSIGSIVSKIDAVIVKLEIMERAKLKRREVLGRLLDGVAEDERLGRDSEI
HREQMERLVREELERWESDDAASQISHGLGTPVGLNGQPRPRSSRPSSSQSTEGMEGAGG
NGSSNVHV
|
| External Links |
|---|
| GenBank ID Protein
| 3126905 |
| UniProtKB/Swiss-Prot ID
| Q13563 |
| UniProtKB/Swiss-Prot Entry Name
| PKD2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF004873 |
| GeneCard ID
| PKD2 |
| GenAtlas ID
| PKD2 |
| HGNC ID
| HGNC:9009 |
| References |
|---|
| General References
| Not Available |