| Identification |
|---|
| HMDB Protein ID
| CDBP03093 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protocadherin alpha-2 |
| Description
| Not Available |
| Synonyms
|
- PCDH-alpha-2
|
| Gene Name
| PCDHA2 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain |
| GO Classification
|
| Component |
| membrane |
| cell part |
| plasma membrane |
| Function |
| metal ion binding |
| binding |
| calcium ion binding |
| ion binding |
| cation binding |
| Process |
| cell adhesion |
| cellular process |
| cell-cell adhesion |
| homophilic cell adhesion |
|
| Cellular Location
|
- Cell membrane
- Single-pass type I membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q31 |
| SNPs
| PCDHA2 |
| Gene Sequence
|
>2847 bp
ATGGCGTCTTCTATCAGAAGGGGCCGAGGGGCCTGGACACGGCTGCTCTCGCTTCTGCTC
CTCGCAGCCTGGGAGGTGGGGAGCGGCCAGCTCCGCTACTCCGTCCCCGAGGAGGCCAAA
CACGGCACCTTCGTGGGCCGCATCGCGCAGGACCTGGGGCTGGAGCTGGAGGAGCTGGTG
CCGCGCCTGTTCCGGGTGGCGTCCAAAAGACACGGGGACCTTCTGGAGGTAAATCTGCAG
AATGGCATTTTGTTTGTGAATTCTCGGATCGACCGGGAGGAGCTGTGCGGGCGGAGCGCG
GAATGTAGCATCCACGTGGAGGTGATCGTGGACAGGCCGCTGCAGGTTTTCCATGTGGAA
GTGGAGGTGAAGGACATTAACGACAACCCGCCAATATTTCCAATGACAGTAAAGACTATC
CGGTTTCCCGAATCAAGGCTGCTTGATTCTCGGTTTCCTCTAGAGGGAGCATCTGATGCA
GATATAGGAGTAAATGCTCTTCTCTCCTACAAGCTCAGCTCCAGTGAGTTTTTCTTCCTA
GATATACAGGCAAATGATGAACTAAGCGAATCTTTGTCTCTCGTGCTGGGGAAATCGCTG
GACAGAGAGGAAACTGCTGAGGTTAATTTGTTACTGGTGGCTACTGATGGGGGCAAACCT
GAGCTCACGGGCACCGTTCAAATACTTATTAAGGTATTAGATGTAAATGACAATGAACCA
ACTTTTGCCCAATCAGTTTACAAAGTAAAATTGTTAGAGAATACGGCAAATGGGACCTTA
GTGGTTAAGTTAAACGCTTCTGATGCAGATGAAGGACCGAACAGCGAGATTGTGTATTCA
CTCGGTAGTGATGTGTCCTCCACTATACAGACTAAGTTTACCATAGATCCCATCTCAGGG
GAAATCAGAACTAAGGGAAAATTAGATTATGAAGAAGCAAAGTCCTACGAGATTCAGGTC
ACTGCAACTGACAAAGGAACCCCTTCAATGTCAGGACATTGTAAAATTTCATTAAAACTT
GTGGACATCAATGATAACACACCAGAAGTCTCAATAACGTCTCTCTCACTTCCCATCTCA
GAGAACGCTTCCCTGGGCACTGTCATTGCTCTCATCACGGTGTCGGATCGCGACTCTGGT
ACGAATGGACATGTCACCTGCTCCCTGACGCCCCACGTCCCTTTCAAGCTGGTGTCCACC
TTCAAGAATTACTACTCGTTGGTGCTGGACAGCGCCCTGGACCGCGAGAGCGTGTCAGCC
TATGAGCTGGTGGTGACCGCACGGGACGGGGGCTCGCCTTCACTGTGGGCCACCACCAGC
GTGTCCATCGAGGTGGCCGACGTGAACGACAACGCGCCGGCGTTCGCACAGCCTGAGTAC
ACAGTATTCGTGAAGGAGAACAACCCGCCGGGCTGCCACATCTTCACGGTGTCAGCGTGG
GATGCGGACGCGCAGGAGAACGCGCTGGTGTCCTACTCGCTGGTGGAGCGGCGGGTGGGC
GAGCGCGCGTTGTCGAGCTACGTTTCGGTGCACGCGGAGAGCGGCAAGGTGTACGCGCTG
CAGCCGCTGGACCACGAGGAAGTGGAGCTGCTGCAGTTCCAGGTGAGCGCGCGGGATGCG
GGCGTGCCGCCTCTGGGCAGCAACGTGACGCTGCAGGTGTTCGTGCTGGACGAGAACGAC
AACGCGCCGGCACTGTTGGCGCCTAGGGCTGGCACCGCTGCTGGCGCAGTGAGTGAGCTG
GTGCCGTGGTCGGTGGGTGCAGGGCACGTGGTGGCGAAGGTGCGCGCAGTGGACGCTGAC
TCAGGCTACAACGCGTGGCTTTCGTACGAGCTTCAGCTGGGTACTGGCAGCGCTCGCATC
CCGTTCCGCGTGGGGCTATACACGGGTGAGATCAGCACGACACGTGCCCTAGACGAGGCT
GACTCCCCTCGACACCGCCTACTCGTGCTGGTGAAGGACCACGGCGAACCAGCGTTGACA
GCCACGGCCACCGTGTTAGTGTCGTTGGTGGAAAGTGGCCAGGCACCCAAGGCCTCGTCG
CGGGCGTGGGTGGGCGCCGCGGGCTCAGAGGCTACGCTGGTGGATGTCAACGTGTACCTG
ATCATCGCCATCTGCGCGGTATCCAGCCTGTTGGTGCTCACGGTGCTGCTGTACACTGCG
CTGCGGTGCTCGGTGCCACCCACCGAGGGTGCGCGCGCGCCAGGAAAGCCCACGCTGGTG
TGCTCCAGCGCCGTGGGGAGCTGGTCTTACTCGCAGCAGAGGCGGCAGAGGGTGTGCTCT
GGGGAGGACCCCCCCAAGACGGACCTCATGGCCTTCAGCCCTAGCTTATCTCAAGGTCCA
GACTCCGCAGAAGAGAAACAGCTCTCAGAATCAGAATACGTAGGAAAGCCACGACAGCCC
AACCCTGACTGGCGTTACTCTGCCTCCCTGAGAGCAGGCATGCACAGCTCTGTGCACCTA
GAGGAGGCTGGCATTCTACGGGCTGGTCCAGGAGGGCCTGATCAGCAGTGGCCAACAGTA
TCCAGTGCAACACCAGAACCAGAGGCAGGAGAAGTGTCCCCTCCAGTCGGTGCGGGTGTC
AACAGCAACAGCTGGACCTTTAAATACGGACCAGGCAACCCCAAACAATCCGGTCCCGGT
GAGTTGCCCGACAAATTCATTATCCCAGGATCTCCTGCAATCATCTCCATCCGGCAGGAG
CCTACTAACAGCCAAATTGACAAAAGTGACTTCATAACCTTCGGCAAAAAGGAGGAGACC
AAGAAAAAGAAGAAAAAGAAGAAGGGTAACAAGACCCAGGAGAAAAAAGAGAAAGGGAAC
AGCACGACTGACAACAGTGACCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 948 |
| Molecular Weight
| 102061.8 |
| Theoretical pI
| 4.83 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Protocadherin alpha-2
MASSIRRGRGAWTRLLSLLLLAAWEVGSGQLRYSVPEEAKHGTFVGRIAQDLGLELEELV
PRLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHVEVIVDRPLQVFHVE
VEVKDINDNPPIFPMTVKTIRFPESRLLDSRFPLEGASDADIGVNALLSYKLSSSEFFFL
DIQANDELSESLSLVLGKSLDREETAEVNLLLVATDGGKPELTGTVQILIKVLDVNDNEP
TFAQSVYKVKLLENTANGTLVVKLNASDADEGPNSEIVYSLGSDVSSTIQTKFTIDPISG
EIRTKGKLDYEEAKSYEIQVTATDKGTPSMSGHCKISLKLVDINDNTPEVSITSLSLPIS
ENASLGTVIALITVSDRDSGTNGHVTCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSA
YELVVTARDGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAW
DADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEEVELLQFQVSARDA
GVPPLGSNVTLQVFVLDENDNAPALLAPRAGTAAGAVSELVPWSVGAGHVVAKVRAVDAD
SGYNAWLSYELQLGTGSARIPFRVGLYTGEISTTRALDEADSPRHRLLVLVKDHGEPALT
ATATVLVSLVESGQAPKASSRAWVGAAGSEATLVDVNVYLIIAICAVSSLLVLTVLLYTA
LRCSVPPTEGARAPGKPTLVCSSAVGSWSYSQQRRQRVCSGEDPPKTDLMAFSPSLSQGP
DSAEEKQLSESEYVGKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTV
SSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQE
PTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
|
| External Links |
|---|
| GenBank ID Protein
| 9256584 |
| UniProtKB/Swiss-Prot ID
| Q9Y5H9 |
| UniProtKB/Swiss-Prot Entry Name
| PCDA2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_018905.2 |
| GeneCard ID
| PCDHA2 |
| GenAtlas ID
| PCDHA2 |
| HGNC ID
| HGNC:8668 |
| References |
|---|
| General References
| Not Available |