Identification
HMDB Protein ID CDBP03092
Secondary Accession Numbers Not Available
Name Protocadherin alpha-1
Description Not Available
Synonyms
  1. PCDH-alpha-1
Gene Name PCDHA1
Protein Type Metal Binding
Biological Properties
General Function Involved in calcium ion binding
Specific Function Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain
GO Classification
Component
membrane
cell part
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
homophilic cell adhesion
cell adhesion
cellular process
cell-cell adhesion
Cellular Location
  1. Isoform 2:Secreted (Potential)
Pathways
Gene Properties
Chromosome Location Chromosome:5
Locus 5q31
SNPs PCDHA1
Gene Sequence
>2853 bp
ATGGTGTTTTCTAGGAGAGGGGGCCTGGGAGCCCGGGATCTGCTTCTTTGGCTTCTGCTC
CTCGCAGCCTGGGAGGTGGGGAGCGGCCAGCTCCACTACTCGATCCCGGAGGAAGCCAAA
CACGGCACCTTCGTTGGCCGCGTTGCTCAGGACCTGGGACTGGAGCTGGCGGAGCTGGTG
CCTCGCCTGTTCCGGGTGGCGTCCAAAACACACAGGGACCTTCTGGAGGTAAATCTGCAG
AATGGCATTTTGTTTGTGAATTCTCGGATCGATCGCGAGGAGCTGTGCCAGTGGAGCGCG
GAGTGCAGCATCCACCTGGAGTTGATCGCCGACAGGCCGCTGCAGGTTTTCCATGTGGAG
GTGAAGGTGAAAGACATTAACGATAATCCACCCGTCTTCAGGGGCAGAGAACAAATAATA
TTTATTCCTGAATCTAGACTCCTGAATTCGCGTTTTCCGATAGAAGGAGCTGCTGATGCA
GACATTGGTGCTAACGCTCTTCTAACGTACACGCTCAGCCCGAGTGATTATTTCTCTTTG
GATGTAGAGGCAAGTGATGAACTGAGTAAATCTCTTTGGCTTGAATTGAGAAAATATTTG
GATAGAGAAGAAACACCAGAACTTCACTTATTACTGACTGCCACTGATGGGGGCAAACCG
GAGCTGCAAGGTACAGTTGAGCTGCTGATCACCGTCCTCGACGTTAATGATAACGCCCCA
CTGTTTGACCAGGCCGTATACAGAGTCCACTTGTTAGAGACTACAGCAAATGGAACATTA
GTGACCACATTAAATGCCTCTGATGCTGACGAAGGTGTAAATGGTGAAGTCGTCTTTTCC
TTTGACAGTGGTATTTCTCGTGACATTCAAGAAAAATTCAAAGTTGATTCCAGCTCAGGA
GAAATTAGGTTAATTGATAAACTGGATTATGAAGAAACAAAATCCTACGAAATTCAAGTA
AAGGCAGTTGATAAAGGAAGTCCTCCGATGTCAAATCACTGTAAGGTTTTGGTGAAAGTG
CTGGATGTAAATGATAATGCTCCAGAACTGGCGGTCACTTCATTGTATTTGCCTATCAGA
GAGGACGCTCCACTCAGCACCGTCATCGCCCTCATCACCGTGTCTGACCGTGACTCAGGT
GCCAACGGGCAGGTGACTTGCTCCTTAATGCCCCACGTCCCCTTCAAGCTGGTGTCCACC
TTCAAGAATTACTACTCGTTGGTGTTGGACAGCGCCCTGGATCGCGAGAGCCTGTCGGTC
TATGAGCTGGTGGTGACCGCGCGGGACGGGGGCTCGCCTTCGCTGTGGGCCACGGCCAGG
GTGTCCGTGGAGGTGGCCGACGTGAATGACAACGCGCCTGCGTTCGCGCAGCCCGAGTAC
ACAGTATTCGTGAAGGAGAACAACCCGCCGGGCTGCCACATCTTCACGGTGTCTGCGCGG
GACGCGGACGCGCAGGAGAACGCGCTGGTGTCCTATTCGCTGGTGGAACGGCGGGTGGGC
GAGCGCGCGCTGTCGAACTACGTGTCAGTGCACGCGGAGAGCGGCAAGGTGTACGCACTG
CAGCCCCTGGACCACGAGGAGCTGGAGCTGCTGCAGTTCCAGGTGAGCGCGCGGGATGCG
GGCGTGCCGCCTCTGGGCAGCAACGTGACGCTGCAGGTGTTCGTGCTGGACGAGAACGAC
AACGCGCCGGCGCTGCTGGCGCCTCGAGTGGGTGGCACTATTGGTGCAGTCAGTGAGCTG
GTGCCGCGATTGGTGGGTGCGGGTCATGTGGTGGCGAAGGTGCGCGCAGTGGACGCCGAC
TCGGGCTACAACGCGTGGCTGTCCTATGAACTGCAGCCGGCAGCAGGCGGCGCGCGCATC
CCGTTCCGCGTGGGGCTGTACACGGGCGAGATCAGCACGACTCGTGTCCTGGACGAGGCT
GACTTGTCGCGCTACCGCCTTCTGGTGCTAGTGAAGGATCACGGTGAGCCGGCGCTGACA
GCCACGGCCACTGTGCTTGTATCTCTGGTGGAGAGCGGCCAGGCGCCAAAGGCGTCTTCG
CGGGCGTCGGTGGGTGTCGCGGGCCCAGAGGCGGCGCTGGTGGATGTCAACGTGTACCTG
ATCATCGCCATCTGCGCGGTGTCCAGCCTGCTGGTGCTCACACTGCTGCTGTACACGGCG
CTGCGGTGCTCAGTGCCGCCCACTGAGGGTGCGTATGTGCCGGGCAAGCCCACTCTGGTG
TGCTCCAGCGCGTTGGGGAGCTGGTCGAACTCACAGCAGAGGCGGCAGAGGGTGTGCTCT
AGCGAGGGCCCACCCAAGACCGACCTCATGGCCTTCAGCCCAGGCCTATCTCCAAGTCTT
AACACGTCAGAAAGAAATGAACAACCAGAAGCAAATTTGGATCTTTCTGGTAATCCACGA
CAGCCCAACCCTGACTGGCGTTACTCTGCCTCCCTGAGAGCAGGCATGCACAGCTCTGTG
CACCTAGAGGAGGCTGGCATTCTACGGGCTGGTCCAGGAGGGCCTGATCAGCAGTGGCCA
ACAGTATCCAGTGCAACACCAGAACCAGAGGCAGGAGAAGTGTCCCCTCCAGTCGGTGCG
GGTGTCAACAGCAACAGCTGGACCTTTAAATACGGACCAGGCAACCCCAAACAATCCGGT
CCCGGTGAGTTGCCCGACAAATTCATTATCCCAGGATCTCCTGCAATCATCTCCATCCGG
CAGGAGCCTACTAACAGCCAAATTGACAAAAGTGACTTCATAACCTTCGGCAAAAAGGAG
GAGACCAAGAAAAAGAAGAAAAAGAAGAAGGGTAACAAGACCCAGGAGAAAAAAGAGAAA
GGGAACAGCACGACTGACAACAGTGACCAGTGA
Protein Properties
Number of Residues 950
Molecular Weight 102951.1
Theoretical pI 4.78
Pfam Domain Function
Signals
  • ["1-29"]
Transmembrane Regions
  • ["698-718"]
Protein Sequence
>Protocadherin alpha-1
MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV
PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE
VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL
DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP
LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG
EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR
EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV
YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR
DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQVSARDA
GVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTIGAVSELVPRLVGAGHVVAKVRAVDAD
SGYNAWLSYELQPAAGGARIPFRVGLYTGEISTTRVLDEADLSRYRLLVLVKDHGEPALT
ATATVLVSLVESGQAPKASSRASVGVAGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTA
LRCSVPPTEGAYVPGKPTLVCSSALGSWSNSQQRRQRVCSSEGPPKTDLMAFSPGLSPSL
NTSERNEQPEANLDLSGNPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWP
TVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIR
QEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
GenBank ID Protein 9256582
UniProtKB/Swiss-Prot ID Q9Y5I3
UniProtKB/Swiss-Prot Entry Name PCDA1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_018900.2
GeneCard ID PCDHA1
GenAtlas ID PCDHA1
HGNC ID HGNC:8663
References
General References Not Available