| Identification |
|---|
| HMDB Protein ID
| CDBP03071 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sigma non-opioid intracellular receptor 1 |
| Description
| Not Available |
| Synonyms
|
- Aging-associated gene 8 protein
- SIG-1R
- SR-BP
- SR31747-binding protein
- Sigma 1-type opioid receptor
- Sigma1-receptor
- Sigma1R
- hSigmaR1
|
| Gene Name
| SIGMAR1 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in C-8 sterol isomerase activity |
| Specific Function
| Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration |
| GO Classification
|
| Component |
| endoplasmic reticulum |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| Function |
| c-8 sterol isomerase activity |
| intramolecular oxidoreductase activity, transposing c=c bonds |
| isomerase activity |
| intramolecular oxidoreductase activity |
| catalytic activity |
| Process |
| sterol metabolic process |
| metabolic process |
| ergosterol metabolic process |
| ergosterol biosynthetic process |
| small molecule metabolic process |
| alcohol metabolic process |
|
| Cellular Location
|
- Cell membrane
- Endoplasmic reticulum membrane
- Cell junction
- Nucleus outer membrane
- Cell projection
- Nucleus inner membrane
- growth cone
- Lipid droplet
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:9 |
| Locus
| 9p13.3 |
| SNPs
| SIGMAR1 |
| Gene Sequence
|
>672 bp
ATGCAGTGGGCCGTGGGCCGGCGGTGGGCGTGGGCCGCGCTGCTCCTGGCTGTCGCAGCG
GTGCTGACCCAGGTCGTCTGGCTCTGGCTGGGTACGCAGAGCTTCGTCTTCCAGCGCGAA
GAGATAGCGCAGTTGGCGCGGCAGTACGCTGGGCTGGACCACGAGCTGGCCTTCTCTCGT
CTGATCGTGGAGCTGCGGCGGCTGCACCCAGGCCACGTGCTGCCCGACGAGGAGCTGCAG
TGGGTGTTCGTGAATGCGGGTGGCTGGATGGGCGCCATGTGCCTTCTGCACGCCTCGCTG
TCCGAGTATGTGCTGCTCTTCGGCACCGCCTTGGGCTCCCGCGGCCACTCGGGGCGCTAC
TGGGCTGAGATCTCGGATACCATCATCTCTGGCACCTTCCACCAGTGGAGAGAGGGCACC
ACCAAAAGTGAGGTCTTCTACCCAGGGGAGACGGTAGTACACGGGCCTGGTGAGGCAACA
GCTGTGGAGTGGGGGCCAAACACATGGATGGTGGAGTACGGCCGGGGCGTCATCCCATCC
ACCCTGGCCTTCGCGCTGGCCGACACTGTCTTCAGCACCCAGGACTTCCTCACCCTCTTC
TATACTCTTCGCTCCTATGCTCGGGGCCTCCGGCTTGAGCTCACCACCTACCTCTTTGGC
CAGGACCCTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 223 |
| Molecular Weight
| 25127.5 |
| Theoretical pI
| 5.87 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Sigma non-opioid intracellular receptor 1
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q99720 |
| UniProtKB/Swiss-Prot Entry Name
| SGMR1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U75283 |
| GeneCard ID
| SIGMAR1 |
| GenAtlas ID
| SIGMAR1 |
| HGNC ID
| HGNC:8157 |
| References |
|---|
| General References
| Not Available |