| Identification |
|---|
| HMDB Protein ID
| CDBP03067 |
| Secondary Accession Numbers
| Not Available |
| Name
| Neurotensin receptor type 1 |
| Description
| Not Available |
| Synonyms
|
- High-affinity levocabastine-insensitive neurotensin receptor
- NT-R-1
- NTR1
- NTRH
|
| Gene Name
| NTSR1 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor protein signaling pathway |
| Specific Function
| Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol- calcium second messenger system |
| GO Classification
|
| Component |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| cell part |
| Function |
| neuropeptide receptor activity |
| neurotensin receptor activity, g-protein coupled |
| receptor activity |
| molecular transducer activity |
| signal transducer activity |
| peptide receptor activity |
| peptide receptor activity, g-protein coupled |
| Process |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 20q13 |
| SNPs
| NTSR1 |
| Gene Sequence
|
>1257 bp
ATGCGCCTCAACAGCTCCGCGCCGGGAACCCCGGGCACGCCGGCCGCCGACCCCTTCCAG
CGGGCGCAGGCCGGACTGGAGGAGGCGCTGCTGGCCCCGGGCTTCGGCAACGCTTCGGGC
AACGCGTCGGAGCGCGTCCTGGCGGCACCCAGCAGCGAGCTGGACGTGAACACCGACATC
TACTCCAAGGTGCTGGTGACCGCCGTGTACCTGGCGCTCTTCGTGGTGGGCACGGTGGGC
AACACGGTGACGGCGTTCACGCTGGCGCGGAAGAAGTCGCTGCAGAGCCTGCAGAGCACG
GTGCATTACCACCTGGGCAGCCTGGCGCTGTCCGACCTGCTCACCCTGCTGCTGGCCATG
CCCGTGGAGCTGTACAACTTCATCTGGGTGCACCACCCCTGGGCCTTCGGCGACGCCGGC
TGCCGCGGCTACTACTTCCTGCGCGACGCCTGCACCTACGCCACGGCCCTCAACGTGGCC
AGCCTGAGTGTGGAGCGCTACCTGGCCATCTGCCACCCCTTCAAGGCCAAGACCCTCATG
TCCCGAAGCCGCACCAAGAAGTTCATCAGCGCCATCTGGCTCGCCTCGGCCCTGCTGGCG
GTGCCTATGCTGTTCACCATGGGCGAGCAGAACCGCAGCGCCGACGGCCAGCACGCCGGC
GGCCTGGTGTGCACCCCCACCATCCACACTGCCACCGTCAAGGTCGTCATACAGGTCAAC
ACCTTCATGTCCTTCATATTCCCCATGGTGGTCATCTCGGTCCTGAACACCATCATCGCC
AACAAGCTGACCGTCATGGTACGCCAGGCGGCCGAGCAGGGCCAAGTGTGCACGGTCGGG
GGCGAGCACAGCACATTCAGCATGGCCATCGAGCCTGGCAGGGTCCAGGCCCTGCGGCAC
GGCGTGCGCGTCCTACGTGCAGTGGTCATCGCCTTTGTGGTCTGCTGGCTGCCCTACCAC
GTGCGGCGCCTCATGTTCTGCTACATCTCGGATGAGCAGTGGACTCCGTTCCTCTATGAC
TTCTACCACTACTTCTACATGGTGACCAACGCACTCTTCTACGTCAGCTCCACCATCAAC
CCCATCCTGTACAACCTCGTCTCTGCCAACTTCCGCCACATCTTCCTGGCCACACTGGCC
TGCCTCTGCCCGGTGTGGCGGCGCAGGAGGAAGAGGCCAGCCTTCTCGAGGAAGGCCGAC
AGCGTGTCCAGCAACCACACCCTCTCCAGCAATGCCACCCGCGAGACGCTGTACTAG
|
| Protein Properties |
|---|
| Number of Residues
| 418 |
| Molecular Weight
| 46258.3 |
| Theoretical pI
| 9.6 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["64-86", "96-120", "143-164", "188-209", "235-259", "304-325", "344-367"]
|
| Protein Sequence
|
>Neurotensin receptor type 1
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDI
YSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAM
PVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLM
SRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVN
TFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRH
GVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTIN
PILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
|
| External Links |
|---|
| GenBank ID Protein
| 66347257 |
| UniProtKB/Swiss-Prot ID
| P30989 |
| UniProtKB/Swiss-Prot Entry Name
| NTR1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AL035669 |
| GeneCard ID
| NTSR1 |
| GenAtlas ID
| NTSR1 |
| HGNC ID
| HGNC:8039 |
| References |
|---|
| General References
| Not Available |