Cannabis Compound Database: Showing Protein Neuropeptide FF receptor 2 (CDBP03062)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP03062

Secondary Accession Numbers

Not Available

Name

Neuropeptide FF receptor 2

Description

Not Available

Synonyms

G-protein coupled receptor 74
G-protein coupled receptor HLWAR77
Neuropeptide G-protein coupled receptor

Gene Name

NPFFR2

Protein Type

Receptor

Biological Properties

General Function

Involved in G-protein coupled receptor protein signaling pathway

Specific Function

Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system

GO Classification

Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
neuropeptide receptor activity
receptor activity
molecular transducer activity
signal transducer activity
peptide receptor activity
peptide receptor activity, g-protein coupled
Process
signaling
signaling pathway
cell surface receptor linked signaling pathway
g-protein coupled receptor protein signaling pathway

Cellular Location

Cell membrane
Multi-pass membrane protein

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:4

Locus

4q21

SNPs

NPFFR2

Gene Sequence

>1569 bp
ATGAATAGCTTCTTCGGAACCCCAGCGGCCAGCTGGTGCCTCCTGGAAAGTGACGTCTCA
TCTGCACCGGACAAGGAGGCGGGGAGGGAGCGCAGAGCACTCAGCGTCCAGCAGCGCGGC
GGGCCAGCCTGGAGCGGAAGCCTGGAGTGGAGCAGGCAGTCCGCGGGGGACAGACGTCGG
CTGGGATTGAGCCGGCAGACTGCGAAAAGTAGCTGGAGCCGGAGCAGGGACAGAACCTGT
TGCTGCAGACGGGCTTGGTGGATTCTGGTTCCTGCCGCCGACAGGGCTCGCCGGGAGAGG
TTCATCATGAATGAGAAATGGGACACAAACTCTTCAGAAAACTGGCATCCCATCTGGAAT
GTCAATGACACAAAGCATCATCTGTACTCAGATATTAATATTACCTATGTGAACTACTAT
CTTCACCAGCCTCAAGTGGCAGCAATCTTCATTATTTCCTACTTTCTGATCTTCTTTTTG
TGCATGATGGGAAATACTGTGGTTTGCTTTATTGTAATGAGGAACAAACATATGCACACA
GTCACTAATCTCTTCATCTTAAACCTGGCCATAAGTGATTTACTAGTTGGCATATTCTGC
ATGCCTATAACACTGCTGGACAATATTATAGCAGGATGGCCATTTGGAAACACGATGTGC
AAGATCAGTGGATTGGTCCAGGGAATATCTGTCGCAGCTTCAGTCTTTACGTTAGTTGCA
ATTGCTGTAGATAGGTTCCAGTGTGTGGTCTACCCTTTTAAACCAAAGCTCACTATCAAG
ACAGCGTTTGTCATTATTATGATCATCTGGGTCCTAGCCATCACCATTATGTCTCCATCT
GCAGTAATGTTACATGTGCAAGAAGAAAAATATTACCGAGTGAGACTCAACTCCCAGAAT
AAAACCAGTCCAGTCTACTGGTGCCGGGAAGACTGGCCAAATCAGGAAATGAGGAAGATC
TACACCACTGTGCTGTTTGCCAACATCTACCTGGCTCCCCTCTCCCTCATTGTCATCATG
TATGGAAGGATTGGAATTTCACTCTTCAGGGCTGCAGTTCCTCACACAGGCAGGAAGAAC
CAGGAGCAGTGGCACGTGGTGTCCAGGAAAAAGCAGAAGATCATTAAGATGCTCCTGATT
GTGGCCCTGCTTTTTATTCTCTCATGGCTGCCCCTGTGGACTCTAATGATGCTCTCAGAC
TACGCTGACCTTTCTCCAAATGAACTGCAGATCATCAACATCTACATCTACCCTTTTGCA
CACTGGCTGGCATTCGGCAACAGCAGTGTCAATCCCATCATTTATGGTTTCTTCAACGAG
AATTTCCGCCGTGGTTTCCAAGAAGCTTTCCAGCTCCAGCTCTGCCAAAAAAGAGCAAAG
CCTATGGAAGCTTATACCCTAAAAGCTAAAAGCCATGTGCTCATAAACACATCTAATCAG
CTTGTCCAGGAATCTACATTTCAAAACCCTCATGGGGAAACCTTGCTTTATAGGAAAAGT
GCTGAAAAACCCCAACAGGAATTAGTGATGGAAGAATTAAAAGAAACTACTAACAGCAGT
GAGATTTAA

Protein Properties

Number of Residues

522

Molecular Weight

60269.7

Theoretical pI

9.69

Pfam Domain Function

7tm_1 (PF00001 )

Signals

["None"]

Transmembrane Regions

["148-168", "185-205", "222-242", "263-283", "320-340", "378-398", "414-434"]

Protein Sequence

>Neuropeptide FF receptor 2
MNSFFGTPAASWCLLESDVSSAPDKEAGRERRALSVQQRGGPAWSGSLEWSRQSAGDRRR
LGLSRQTAKSSWSRSRDRTCCCRRAWWILVPAADRARRERFIMNEKWDTNSSENWHPIWN
VNDTKHHLYSDINITYVNYYLHQPQVAAIFIISYFLIFFLCMMGNTVVCFIVMRNKHMHT
VTNLFILNLAISDLLVGIFCMPITLLDNIIAGWPFGNTMCKISGLVQGISVAASVFTLVA
IAVDRFQCVVYPFKPKLTIKTAFVIIMIIWVLAITIMSPSAVMLHVQEEKYYRVRLNSQN
KTSPVYWCREDWPNQEMRKIYTTVLFANIYLAPLSLIVIMYGRIGISLFRAAVPHTGRKN
QEQWHVVSRKKQKIIKMLLIVALLFILSWLPLWTLMMLSDYADLSPNELQIINIYIYPFA
HWLAFGNSSVNPIIYGFFNENFRRGFQEAFQLQLCQKRAKPMEAYALKAKSHVLINTSNQ
LVQESTFQNPHGETLLYRKSAEKPQQELVMEELKETTNSSEI

External Links

GenBank ID Protein

4530469

UniProtKB/Swiss-Prot ID

Q9Y5X5

UniProtKB/Swiss-Prot Entry Name

NPFF2_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF119815

GeneCard ID