| Identification |
|---|
| HMDB Protein ID
| CDBP03061 |
| Secondary Accession Numbers
| Not Available |
| Name
| Neuropeptide FF receptor 1 |
| Description
| Not Available |
| Synonyms
|
- G-protein coupled receptor 147
- RFamide-related peptide receptor OT7T022
|
| Gene Name
| NPFFR1 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor protein signaling pathway |
| Specific Function
| Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| neuropeptide receptor activity |
| receptor activity |
| molecular transducer activity |
| signal transducer activity |
| peptide receptor activity |
| peptide receptor activity, g-protein coupled |
| Process |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 10q21-q22 |
| SNPs
| NPFFR1 |
| Gene Sequence
|
>1293 bp
ATGGAGGGGGAGCCCTCCCAGCCTCCCAACAGCAGTTGGCCCCTAAGTCAGAATGGGACT
AACACTGAGGCCACCCCGGCTACAAACCTCACCTTCTCCTCCTACTATCAGCACACCTCC
CCTGTGGCGGCCATGTTCATTGTGGCCTATGCGCTCATCTTCCTGCTCTGCATGGTGGGC
AACACCCTGGTCTGTTTCATCGTGCTCAAGAACCGGCACATGCATACTGTCACCAACATG
TTCATCCTCAACCTGGCTGTCAGTGACCTGCTGGTGGGCATCTTCTGCATGCCCACCACC
CTTGTGGACAACCTCATCACTGGGTGGCCCTTCGACAATGCCACATGCAAGATGAGCGGC
TTGGTGCAGGGCATGTCTGTGTCGGCTTCCGTTTTCACACTGGTGGCCATTGCTGTGGAA
AGGTTCCGCTGCATCGTGCACCCTTTCCGCGAGAAGCTGACCCTGCGGAAGGCGCTCGTC
ACCATCGCCGTCATCTGGGCCCTGGCGCTGCTCATCATGTGTCCCTCGGCCGTCACGCTG
ACCGTCACCCGTGAGGAGCACCACTTCATGGTGGACGCCCGCAACCGCTCCTACCCTCTC
TACTCCTGCTGGGAGGCCTGGCCCGAGAAGGGCATGCGCAGGGTCTACACCACTGTGCTC
TTCTCGCACATCTACCTGGCGCCGCTGGCGCTCATCGTGGTCATGTACGCCCGCATCGCG
CGCAAGCTCTGCCAGGCCCCGGGCCCGGCCCCCGGGGGCGAGGAGGCTGCGGACCCGCGA
GCATCGCGGCGCAGAGCGCGCGTGGTGCACATGCTGGTCATGGTGGCGCTGTTCTTCACG
CTGTCCTGGCTGCCGCTCTGGGCGCTGCTGCTGCTCATCGACTACGGGCAGCTCAGCGCG
CCGCAGCTGCACCTGGTCACCGTCTACGCCTTCCCCTTCGCGCACTGGCTGGCCTTCTTC
AACAGCAGCGCCAACCCCATCATCTACGGCTACTTCAACGAGAACTTCCGCCGCGGCTTC
CAGGCCGCCTTCCGCGCCCGCCTCTGCCCGCGCCCGTCGGGGAGCCACAAGGAGGCCTAC
TCCGAGCGGCCCGGCGGGCTTCTGCACAGGCGGGTCTTCGTGGTGGTGCGGCCCAGCGAC
TCCGGGCTGCCCTCTGAGTCGGGCCCTAGCAGTGGGGCCCCCAGGCCCGGCCGCCTCCCG
CTGCGGAATGGGCGGGTGGCTCACCACGGCTTGCCCAGGGAAGGGCCTGGCTGCTCCCAC
CTGCCCCTCACCATTCCAGCCTGGGATATCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 430 |
| Molecular Weight
| 47818.4 |
| Theoretical pI
| 9.63 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["44-64", "81-101", "118-138", "159-179", "215-235", "272-292", "308-328"]
|
| Protein Sequence
|
>Neuropeptide FF receptor 1
MEGEPSQPPNSSWPLSQNGTNTEATPATNLTFSSYYQHTSPVAAMFIVAYALIFLLCMVG
NTLVCFIVLKNRHMHTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNATCKMSG
LVQGMSVSASVFTLVAIAVERFRCIVHPFREKLTLRKALVTIAVIWALALLIMCPSAVTL
TVTREEHHFMVDARNRSYPLYSCWEAWPEKGMRRVYTTVLFSHIYLAPLALIVVMYARIA
RKLCQAPGPAPGGEEAADPRASRRRARVVHMLVMVALFFTLSWLPLWALLLLIDYGQLSA
PQLHLVTVYAFPFAHWLAFFNSSANPIIYGYFNENFRRGFQAAFRARLCPRPSGSHKEAY
SERPGGLLHRRVFVVVRPSDSGLPSESGPSSGAPRPGRLPLRNGRVAHHGLPREGPGCSH
LPLTIPAWDI
|
| External Links |
|---|
| GenBank ID Protein
| 11125702 |
| UniProtKB/Swiss-Prot ID
| Q9GZQ6 |
| UniProtKB/Swiss-Prot Entry Name
| NPFF1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB040104 |
| GeneCard ID
| NPFFR1 |
| GenAtlas ID
| NPFFR1 |
| HGNC ID
| HGNC:17425 |
| References |
|---|
| General References
| Not Available |