| Identification |
|---|
| HMDB Protein ID
| CDBP03057 |
| Secondary Accession Numbers
| Not Available |
| Name
| Substance-K receptor |
| Description
| Not Available |
| Synonyms
|
- NK-2 receptor
- NK-2R
- Neurokinin A receptor
- SKR
- Tachykinin receptor 2
|
| Gene Name
| TACR2 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor protein signaling pathway |
| Specific Function
| This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is:substance K > neuromedin-K > substance P |
| GO Classification
|
| Component |
| membrane |
| cell part |
| membrane part |
| plasma membrane |
| intrinsic to membrane |
| integral to membrane |
| Function |
| peptide receptor activity, g-protein coupled |
| neuropeptide receptor activity |
| tachykinin receptor activity |
| receptor activity |
| molecular transducer activity |
| signal transducer activity |
| peptide receptor activity |
| Process |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 10q11-q21 |
| SNPs
| TACR2 |
| Gene Sequence
|
>1197 bp
ATGGGGACCTGTGACATTGTGACTGAAGCCAATATCTCATCTGGCCCTGAGAGCAACACC
ACGGGCATCACAGCCTTCTCCATGCCCAGCTGGCAACTGGCACTGTGGGCCACAGCCTAC
CTGGCCCTGGTGCTGGTGGCCGTGACGGGTAATGCCATCGTCATCTGGATCATCCTGGCC
CATCGGAGGATGCGCACAGTCACCAACTACTTCATCGTCAATCTGGCGCTGGCTGACCTC
TGCATGGCTGCCTTCAATGCCGCCTTCAACTTTGTCTATGCCAGCCACAACATCTGGTAC
TTTGGCCGTGCCTTCTGCTACTTCCAGAACCTCTTCCCCATCACAGCCATGTTTGTCAGC
ATCTACTCCATGACCGCCATTGCTGCCGACAGGTACATGGCCATCGTCCACCCCTTCCAG
CCTCGGCTTTCAGCTCCCAGCACCAAGGCGGTTATTGCTGGCATCTGGCTGGTGGCTCTC
GCCCTGGCCTCCCCTCAGTGCTTCTACTCCACCGTCACCATGGACCAGGGTGCCACCAAG
TGCGTGGTGGCCTGGCCCGAAGACAGCGGGGGCAAGACGCTCCTCCTGTACCACCTCGTG
GTGATCGCCCTCATCTACTTCCTGCCGCTCGCGGTGATGTTTGTAGCCTACAGCGTCATC
GGCCTCACGCTCTGGAGGCGCGCAGTGCCCGGACATCAGGCGCACGGTGCCAACCTGCGC
CACCTGCAGGCCATGAAGAAGTTTGTGAAGACCATGGTGCTGGTGGTGCTGACGTTTGCC
ATCTGCTGGCTGCCCTACCACCTCTACTTCATCCTGGGCAGCTTCCAGGAGGACATCTAC
TGCCACAAGTTCATCCAGCAAGTCTACCTGGCACTCTTCTGGTTGGCCATGAGCTCTACC
ATGTACAATCCCATCATCTACTGCTGTCTCAACCACAGGTTTCGCTCTGGATTCCGGCTT
GCCTTCCGCTGCTGCCCATGGGTCACACCCACCAAGGAAGATAAGCTCGAGCTGACTCCC
ACGACCTCCCTCTCCACGAGAGTCAACAGGTGTCACACTAAGGAGACTTTGTTCATGGCT
GGGGACACAGCCCCCTCCGAGGCTACCAGTGGGGAGGCGGGGCGTCCCCAGGATGGATCA
GGGCTATGGTTTGGGTATGGTTTGCTTGCCCCCACCAAAACTCATGTTGAAATTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 398 |
| Molecular Weight
| 44441.7 |
| Theoretical pI
| 8.63 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["33-56", "70-90", "108-129", "150-170", "197-218", "252-272", "291-310"]
|
| Protein Sequence
|
>Substance-K receptor
MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILA
HRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVS
IYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATK
CVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLR
HLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSST
MYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMA
GDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
|
| External Links |
|---|
| GenBank ID Protein
| 21928731 |
| UniProtKB/Swiss-Prot ID
| P21452 |
| UniProtKB/Swiss-Prot Entry Name
| NK2R_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB065731 |
| GeneCard ID
| TACR2 |
| GenAtlas ID
| TACR2 |
| HGNC ID
| HGNC:11527 |
| References |
|---|
| General References
| Not Available |