| Identification |
|---|
| HMDB Protein ID
| CDBP03051 |
| Secondary Accession Numbers
| Not Available |
| Name
| Neuronal calcium sensor 1 |
| Description
| Not Available |
| Synonyms
|
- Frequenin homolog
- Frequenin-like protein
- Frequenin-like ubiquitous protein
- NCS-1
|
| Gene Name
| NCS1 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N- type voltage-gated calcium channel |
| GO Classification
|
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
|
| Cellular Location
|
- Cell membrane
- Cytoplasm
- perinuclear region
- Peripheral membrane protein
- Peripheral membrane protein
- Golgi apparatus
- Golgi stack membrane
- Cell junction
- synapse
- postsynaptic cell membrane
- postsynaptic density
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:9 |
| Locus
| 9q34 |
| SNPs
| NCS1 |
| Gene Sequence
|
>573 bp
ATGGGGAAATCCAACAGCAAGTTGAAGCCCGAAGTTGTGGAGGAGCTGACCAGGAAGACC
TACTTTACCGAGAAGGAGGTCCAGCAGTGGTACAAAGGCTTCATCAAGGACTGCCCCAGT
GGGCAGCTGGATGCGGCAGGCTTCCAGAAGATCTACAAGCAATTCTTCCCGTTCGGAGAC
CCCACCAAGTTTGCCACATTTGTTTTCAACGTCTTTGATGAAAACAAGGACGGGCGAATT
GAGTTCTCCGAGTTCATCCAGGCGCTGTCGGTGACCTCACGGGGAACCCTGGATGAGAAG
CTACGGTGGGCCTTCAAGCTCTACGACTTGGACAATGATGGCTACATCACCAGGAATGAG
ATGCTGGACATTGTGGATGCCATTTACCAGATGGTGGGGAATACCGTGGAGCTCCCAGAG
GAGGAGAACACTCCTGAGAAGAGGGTGGACCGGATCTTTGCCATGATGGATAAGAATGCC
GACGGGAAGCTGACCCTGCAGGAGTTCCAGGAGGGTTCCAAGGCAGACCCGTCCATTGTG
CAGGCGCTGTCCCTCTACGACGGGCTGGTATAG
|
| Protein Properties |
|---|
| Number of Residues
| 190 |
| Molecular Weight
| 21878.6 |
| Theoretical pI
| 4.44 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Neuronal calcium sensor 1
MGKSNSKLKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGD
PTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNE
MLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQEGSKADPSIV
QALSLYDGLV
|
| External Links |
|---|
| GenBank ID Protein
| 9798526 |
| UniProtKB/Swiss-Prot ID
| P62166 |
| UniProtKB/Swiss-Prot Entry Name
| NCS1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| X84048 |
| GeneCard ID
| NCS1 |
| GenAtlas ID
| NCS1 |
| HGNC ID
| HGNC:3953 |
| References |
|---|
| General References
| Not Available |