| Identification |
|---|
| HMDB Protein ID
| CDBP03046 |
| Secondary Accession Numbers
| Not Available |
| Name
| NKG2D ligand 3 |
| Description
| Not Available |
| Synonyms
|
- ALCAN-gamma
- N2DL-3
- NKG2DL3
- Retinoic acid early transcript 1N
|
| Gene Name
| ULBP3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in immune response |
| Specific Function
| Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. Has lower affinity for NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does ULBP2 or ULBP1 |
| GO Classification
|
| Component |
| mhc protein complex |
| mhc class i protein complex |
| membrane |
| cell part |
| macromolecular complex |
| protein complex |
| Process |
| antigen processing and presentation |
| immune system process |
| immune response |
|
| Cellular Location
|
- Cell membrane
- Lipid-anchor
- GPI-anchor
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:6 |
| Locus
| 6q25 |
| SNPs
| ULBP3 |
| Gene Sequence
|
>735 bp
ATGGCAGCGGCCGCCAGCCCCGCGATCCTTCCGCGCCTCGCGATTCTTCCGTACCTGCTA
TTCGACTGGTCCGGGACGGGGCGGGCCGACGCTCACTCTCTCTGGTATAACTTCACCATC
ATTCATTTGCCCAGACATGGGCAACAGTGGTGTGAGGTCCAGAGCCAGGTGGATCAGAAG
AATTTTCTCTCCTATGACTGTGGCAGTGACAAGGTCTTATCTATGGGTCACCTAGAAGAG
CAGCTGTATGCCACAGATGCCTGGGGAAAACAACTGGAAATGCTGAGAGAGGTGGGGCAG
AGGCTCAGACTGGAACTGGCTGACACTGAGCTGGAGGATTTCACACCCAGTGGACCCCTC
ACGCTGCAGGTCAGGATGTCTTGTGAGTGTGAAGCCGATGGATACATCCGTGGATCTTGG
CAGTTCAGCTTCGATGGACGGAAGTTCCTCCTCTTTGACTCAAACAACAGAAAGTGGACA
GTGGTTCACGCTGGAGCCAGGCGGATGAAAGAGAAGTGGGAGAAGGATAGCGGACTGACC
ACCTTCTTCAAGATGGTCTCAATGAGAGACTGCAAGAGCTGGCTTAGGGACTTCCTGATG
CACAGGAAGAAGAGGCTGGAACCCACAGCACCACCCACCATGGCCCCAGGCTTAGCTCAA
CCCAAAGCCATAGCCACCACCCTCAGTCCCTGGAGCTTCCTCATCATCCTCTGCTTCATC
CTCCCTGGCATCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 244 |
| Molecular Weight
| 27949.0 |
| Theoretical pI
| 8.13 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>NKG2D ligand 3
MAAAASPAILPRLAILPYLLFDWSGTGRADAHSLWYNFTIIHLPRHGQQWCEVQSQVDQK
NFLSYDCGSDKVLSMGHLEEQLYATDAWGKQLEMLREVGQRLRLELADTELEDFTPSGPL
TLQVRMSCECEADGYIRGSWQFSFDGRKFLLFDSNNRKWTVVHAGARRMKEKWEKDSGLT
TFFKMVSMRDCKSWLRDFLMHRKKRLEPTAPPTMAPGLAQPKAIATTLSPWSFLIILCFI
LPGI
|
| External Links |
|---|
| GenBank ID Protein
| 14530667 |
| UniProtKB/Swiss-Prot ID
| Q9BZM4 |
| UniProtKB/Swiss-Prot Entry Name
| N2DL3_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AB052908 |
| GeneCard ID
| ULBP3 |
| GenAtlas ID
| ULBP3 |
| HGNC ID
| HGNC:14895 |
| References |
|---|
| General References
| Not Available |