| Identification |
|---|
| HMDB Protein ID
| CDBP03044 |
| Secondary Accession Numbers
| Not Available |
| Name
| NKG2D ligand 1 |
| Description
| Not Available |
| Synonyms
|
- ALCAN-beta
- N2DL-1
- NKG2DL1
- Retinoic acid early transcript 1I
- UL16-binding protein 1
|
| Gene Name
| ULBP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in immune response |
| Specific Function
| Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis- Golgi apparatus so that it does not reach the cell surface |
| GO Classification
|
| Component |
| mhc protein complex |
| mhc class i protein complex |
| membrane |
| cell part |
| macromolecular complex |
| protein complex |
| Process |
| antigen processing and presentation |
| immune system process |
| immune response |
|
| Cellular Location
|
- Cell membrane
- Lipid-anchor
- GPI-anchor
- Endoplasmic reticulum
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:6 |
| Locus
| 6q25 |
| SNPs
| ULBP1 |
| Gene Sequence
|
>735 bp
ATGGCAGCGGCCGCCAGCCCCGCCTTCCTTCTGTGCCTCCCGCTTCTGCACCTGCTGTCT
GGCTGGTCCCGGGCAGGATGGGTCGACACACACTGTCTTTGCTATGACTTCATCATCACT
CCTAAGTCCAGACCTGAACCACAGTGGTGTGAAGTTCAAGGCCTGGTGGATGAAAGGCCT
TTTCTTCACTATGACTGTGTTAACCACAAGGCCAAAGCCTTTGCTTCTCTGGGGAAGAAA
GTCAATGTCACAAAAACCTGGGAAGAACAAACTGAAACACTAAGAGACGTGGTGGATTTC
CTTAAAGGGCAACTGCTTGACATTCAAGTGGAGAATTTAATACCCATTGAGCCCCTCACC
CTGCAGGCCAGGATGTCTTGTGAGCATGAAGCCCATGGACACGGCAGAGGATCTTGGCAG
TTCCTCTTCAATGGACAGAAGTTCCTCCTCTTTGACTCAAACAACAGAAAGTGGACAGCA
CTTCATCCTGGAGCCAAGAAGATGACAGAGAAGTGGGAGAAGAACAGGGATGTGACCATG
TTCTTCCAGAAGATTTCACTGGGGGATTGTAAGATGTGGCTTGAAGAATTTTTGATGTAC
TGGGAACAAATGCTGGATCCAACAAAACCACCCTCTCTGGCCCCAGGCACAACCCAACCC
AAGGCCATGGCCACCACCCTCAGTCCCTGGAGCCTTCTCATCATCTTCCTCTGCTTCATT
CTAGCTGGCAGATGA
|
| Protein Properties |
|---|
| Number of Residues
| 244 |
| Molecular Weight
| 27996.4 |
| Theoretical pI
| 7.48 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>NKG2D ligand 1
MAAAASPAFLLCLPLLHLLSGWSRAGWVDTHCLCYDFIITPKSRPEPQWCEVQGLVDERP
FLHYDCVNHKAKAFASLGKKVNVTKTWEEQTETLRDVVDFLKGQLLDIQVENLIPIEPLT
LQARMSCEHEAHGHGRGSWQFLFNGQKFLLFDSNNRKWTALHPGAKKMTEKWEKNRDVTM
FFQKISLGDCKMWLEEFLMYWEQMLDPTKPPSLAPGTTQPKAMATTLSPWSLLIIFLCFI
LAGR
|
| External Links |
|---|
| GenBank ID Protein
| 14530665 |
| UniProtKB/Swiss-Prot ID
| Q9BZM6 |
| UniProtKB/Swiss-Prot Entry Name
| N2DL1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB052907 |
| GeneCard ID
| ULBP1 |
| GenAtlas ID
| ULBP1 |
| HGNC ID
| HGNC:14893 |
| References |
|---|
| General References
| Not Available |