Showing Protein Myosin regulatory light chain 12B (CDBP03031)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP03031
Secondary Accession Numbers Not Available
Name Myosin regulatory light chain 12B
Description Not Available
Synonyms
  1. MLC-2
  2. MLC-2A
  3. MLC20
  4. Myosin regulatory light chain 2-B, smooth muscle isoform
  5. Myosin regulatory light chain 20 kDa
  6. Myosin regulatory light chain MRLC2
  7. SHUJUN-1
Gene Name MYL12B
Protein Type Metal Binding
Biological Properties
General Function Involved in calcium ion binding
Specific Function Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 18p11.31
SNPs MYL12B
Gene Sequence 
>519 bp
ATGTCGAGCAAAAAGGCAAAGACCAAGACCACCAAGAAGCGCCCTCAGCGTGCAACATCC
AATGTGTTTGCCATGTTTGACCAGTCACAGATTCAGGAGTTCAAAGAGGCCTTCAACATG
ATTGATCAGAACAGAGATGGCTTCATCGACAAGGAAGATTTGCATGATATGCTTGCTTCT
CTAGGGAAGAATCCCACTGATGCATACCTTGATGCCATGATGAATGAGGCCCCAGGGCCC
ATCAATTTCACCATGTTCCTCACCATGTTTGGTGAGAAGTTAAATGGCACAGATCCTGAA
GATGTCATCAGAAATGCCTTTGCTTGCTTTGATGAAGAAGCAACTGGCACCATACAGGAA
GATTACTTGAGAGAGCTGCTGACAACCATGGGGGATCGGTTTACAGATGAGGAAGTGGAT
GAGCTGTACAGAGAAGCACCTATTGATAAAAAGGGGAATTTCAATTACATCGAGTTCACA
CGCATCCTGAAACATGGAGCCAAAGACAAAGATGACTGA
Protein Properties
Number of Residues 172
Molecular Weight 19779.0
Theoretical pI 4.44
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Myosin regulatory light chain 12B
MSSKKAKTKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLAS
LGKNPTDAYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQE
DYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD
GenBank ID Protein 15076511
UniProtKB/Swiss-Prot ID O14950
UniProtKB/Swiss-Prot Entry Name ML12B_HUMAN
PDB IDs Not Available
GenBank Gene ID AB046614
GeneCard ID MYL12B
GenAtlas ID MYL12B
HGNC ID HGNC:29827
References
General References Not Available