Cannabis Compound Database: Showing Protein Matrix metalloproteinase-24 (CDBP03023)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP03023

Secondary Accession Numbers

Not Available

Name

Matrix metalloproteinase-24

Description

Not Available

Synonyms

MMP-24
MT-MMP 5
MT5-MMP
MT5MMP
MTMMP5
Membrane-type matrix metalloproteinase 5
Membrane-type-5 matrix metalloproteinase
Processed matrix metalloproteinase-24

Gene Name

MMP24

Protein Type

Enzyme

Biological Properties

General Function

Involved in metalloendopeptidase activity

Specific Function

Activates progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin

GO Classification

Component
extracellular region part
extracellular matrix
Function
transition metal ion binding
zinc ion binding
metalloendopeptidase activity
peptidase activity
peptidase activity, acting on l-amino acid peptides
metallopeptidase activity
calcium ion binding
endopeptidase activity
ion binding
cation binding
metal ion binding
binding
catalytic activity
hydrolase activity
Process
metabolic process
macromolecule metabolic process
protein metabolic process
proteolysis

Cellular Location

extracellular space
extracellular matrix
Processed matrix metalloproteinase-24:Secreted

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:2

Locus

20q11.2

SNPs

MMP24

Gene Sequence

>1938 bp
ATGCCGAGGAGCCGGGGCGGCCGCGCCGCGCCGGGGCCGCCGCCGCCGCCGCCGCCGCCG
GGCCAGGCCCCGCGCTGGAGCCGCTGGCGGGTCCCTGGGCGGCTGCTGCTGCTGCTGCTG
CCCGCGCTCTGCTGCCTCCCGGGCGCCGCGCGGGCGGCGGCGGCGGCGGCGGGGGCAGGG
AACCGGGCAGCGGTGGCGGTGGCGGTGGCGCGGGCGGACGAGGCGGAGGCGCCCTTCGCC
GGGCAGAACTGGTTAAAGTCCTATGGCTATCTGCTTCCCTATGACTCACGGGCATCTGCG
CTGCACTCAGCGAAGGCCTTGCAGTCGGCAGTCTCCACTATGCAGCAGTTTTACGGGATC
CCGGTCACCGGTGTGTTGGATCAGACAACGATCGAGTGGATGAAGAAACCCCGATGTGGT
GTCCCTGATCACCCCCACTTAAGCCGTAGGCGGAGAAACAAGCGCTATGCCCTGACTGGA
CAGAAGTGGAGGCAAAAACACATCACCTACAGCATTCACAACTATACCCCAAAAGTGGGT
GAGCTAGACACGCGGAAAGCTATTCGCCAGGCTTTCGATGTGTGGCAGAAGGTGACCCCA
CTGACCTTTGAAGAGGTGCCATACCATGAGATCAAAAGTGACCGGAAGGAGGCAGACATC
ATGATCTTTTTTGCTTCTGGTTTCCATGGCGACAGCTCCCCATTTGATGGAGAAGGGGGA
TTCCTGGCCCATGCCTACTTCCCTGGCCCAGGGATTGGAGGAGACACCCACTTTGACTCC
GATGAGCCATGGACGCTAGGAAATGCCAACCATGACGGGAACGACCTCTTCCTGGTGGCT
GTGCATGAGCTGGGCCACGCGCTGGGACTGGAGCACTCCAGCGACCCCAGCGCCATCATG
GCGCCCTTCTACCAGTACATGGAGACGCACAACTTCAAGCTGCCCCAGGACGATCTCCAG
GGCATCCAGAAGATCTATGGACCCCCAGCCGAGCCTCTGGAGCCCACAAGGCCACTCCCT
ACACTCCCCGTCCGCAGGATCCACTCACCATCGGAGAGGAAACACGAGCGCCAGCCCAGG
CCCCCTCGGCCGCCCCTCGGGGACCGGCCATCCACACCAGGCACCAAACCCAACATCTGT
GACGGCAACTTCAACACAGTGGCCCTCTTCCGGGGCGAGATGTTTGTCTTTAAGGATCGC
TGGTTCTGGCGTCTGCGCAATAACCGAGTGCAGGAGGGCTACCCCATGCAGATCGAGCAG
TTCTGGAAGGGCCTGCCTGCCCGCATCGACGCAGCCTATGAAAGGGCCGATGGGAGATTT
GTCTTCTTCAAAGGTGACAAGTATTGGGTGTTTAAGGAGGTGACGGTGGAGCCTGGGTAC
CCCCACAGCCTGGGGGAGCTGGGCAGCTGTTTGCCCCGTGAAGGCATTGACACAGCTCTG
CGCTGGGAACCTGTGGGCAAGACCTACTTTTTCAAAGGCGAGCGGTACTGGCGCTACAGC
GAGGAGCGGCGGGCCACGGACCCTGGCTACCCTAAGCCCATCACCGTGTGGAAGGGCATT
CCACAGGCTCCCCAAGGAGCCTTCATCAGCAAGGAAGGATATTACACCTATTTCTACAAG
GGCCGGGACTACTGGAAGTTTGACAACCAGAAACTGAGCGTGGAGCCAGGCTACCCGCGC
AACATCCTGCGTGACTGGATGGGCTGCAACCAGAAGGAGGTGGAGCGGCGGAAGGAGCGG
CGGCTGCCCCAGGACGACGTGGACATCATGGTGACCATCAACGATGTGCCGGGCTCCGTG
AACGCCGTGGCCGTGGTCATCCCCTGCATCCTGTCCCTCTGCATCCTGGTGCTGGTCTAC
ACCATCTTCCAGTTCAAGAACAAGACAGGCCCTCAGCCTGTCACCTACTATAAGCGGCCA
GTCCAGGAATGGGTGTGA

Protein Properties

Number of Residues

645

Molecular Weight

73230.9

Theoretical pI

9.58

Pfam Domain Function

Hemopexin (PF00045 )
Peptidase_M10 (PF00413 )
PG_binding_1 (PF01471 )
DUF3377 (PF11857 )

Signals

["1-52"]

Transmembrane Regions

["603-623"]

Protein Sequence

>Matrix metalloproteinase-24
MPRSRGGRAAPGPPPPPPPPGQAPRWSRWRVPGRLLLLLLPALCCLPGAARAAAAAAGAG
NRAAVAVAVARADEAEAPFAGQNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGI
PVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVG
ELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGG
FLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIM
APFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPR
PPRPPLGDRPSTPGTKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQ
FWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTAL
RWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYK
GRDYWKFDNQKLSVEPGYPRNILRDWMGCNQKEVERRKERRLPQDDVDIMVTINDVPGSV
NAVAVVIPCILSLCILVLVYTIFQFKNKTGPQPVTYYKRPVQEWV

External Links

GenBank ID Protein

5381386

UniProtKB/Swiss-Prot ID

Q9Y5R2

UniProtKB/Swiss-Prot Entry Name

MMP24_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF131284

GeneCard ID