| Identification |
|---|
| HMDB Protein ID
| CDBP03021 |
| Secondary Accession Numbers
| Not Available |
| Name
| Matrix metalloproteinase-19 |
| Description
| Not Available |
| Synonyms
|
- MMP-18
- MMP-19
- Matrix metalloproteinase RASI
- Matrix metalloproteinase-18
|
| Gene Name
| MMP19 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in metalloendopeptidase activity |
| Specific Function
| Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin |
| GO Classification
|
| Component |
| extracellular region part |
| extracellular matrix |
| Function |
| transition metal ion binding |
| zinc ion binding |
| metalloendopeptidase activity |
| peptidase activity |
| peptidase activity, acting on l-amino acid peptides |
| metallopeptidase activity |
| calcium ion binding |
| endopeptidase activity |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| hydrolase activity |
| Process |
| metabolic process |
| macromolecule metabolic process |
| protein metabolic process |
| proteolysis |
|
| Cellular Location
|
- Secreted
- extracellular space
- extracellular matrix
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12q14 |
| SNPs
| MMP19 |
| Gene Sequence
|
>1527 bp
ATGAACTGCCAGCAGCTGTGGCTGGGCTTCCTACTCCCCATGACAGTCTCAGGCCGGGTC
CTGGGGCTTGCAGAGGTGGCGCCCGTGGACTACCTGTCACAATATGGGTACCTACAGAAG
CCTCTAGAAGGATCTAATAACTTCAAGCCAGAAGATATCACCGAGGCTCTGAGAGCTTTT
CAGGAAGCATCTGAACTTCCAGTCTCAGGTCAGCTGGATGATGCCACAAGGGCCCGCATG
AGGCAGCCTCGTTGTGGCCTAGAGGATCCCTTCAACCAGAAGACCCTTAAATACCTGTTG
CTGGGCCGCTGGAGAAAGAAGCACCTGACTTTCCGCATCTTGAACCTGCCCTCCACCCTT
CCACCCCACACAGCCCGGGCAGCCCTGCGTCAAGCCTTCCAGGACTGGAGCAATGTGGCT
CCCTTGACCTTCCAAGAGGTGCAGGCTGGTGCGGCTGACATCCGCCTCTCCTTCCATGGC
CGCCAAAGCTCGTACTGTTCCAATACTTTTGATGGGCCTGGGAGAGTCCTGGCCCATGCC
GACATCCCAGAGCTGGGCAGTGTGCACTTCGACGAAGACGAGTTCTGGACTGAGGGGACC
TACCGTGGGGTGAACCTGCGCATCATTGCAGCCCATGAAGTGGGCCATGCTCTGGGGCTT
GGGCACTCCCGATATTCCCAGGCCCTCATGGCCCCAGTCTACGAGGGCTACCGGCCCCAC
TTTAAGCTGCACCCAGATGATGTGGCAGGGATCCAGGCTCTCTATGGCAAGAAGAGTCCA
GTGATAAGGGATGAGGAAGAAGAAGAGACAGAGCTGCCCACTGTGCCCCCAGTGCCCACA
GAACCCAGTCCCATGCCAGACCCTTGCAGTAGTGAACTGGATGCCATGATGCTGGGGCCC
CGTGGGAAGACCTATGCTTTCAAGGGGGACTATGTGTGGACTGTATCAGATTCAGGACCG
GGCCCCTTGTTCCGAGTGTCTGCCCTTTGGGAGGGGCTCCCCGGAAACCTGGATGCTGCT
GTCTACTCGCCTCGAACACAATGGATTCACTTCTTTAAGGGAGACAAGGTGTGGCGCTAC
ATTAATTTCAAGATGTCTCCTGGCTTCCCCAAGAAGCTGAATAGGTCAGAACCTAACCTG
GATGCAGCTCTCTATTGGCCTCTCAACCAAAAGGTGTTCCTCTTTAAGGGCTCCGGGTAC
TGGCAGTGGGACGAGCTAGCCCGAACTGACTTCAGCAGCTACCCCAAACCAATCAAGGGT
TTGTTTACGGGAGTGCCAAACCAGCCCTCGGCTGCTATGAGTTGGCAAGATGGCCGAGTC
TACTTCTTCAAGGGCAAAGTCTACTGGCGCCTCAACCAGCAGCTTCGAGTAGAGAAAGGC
TATCCCAGAAATATTTCCCACAACTGGATGCACTGTCGTCCCCGGACTATAGACACTACC
CCATCAGGTGGGAATACCACTCCCTCAGGTACGGGCATAACCTTGGATACCACTCTCTCA
GCCACAGAAACCACGTTTGAATACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 508 |
| Molecular Weight
| 57356.6 |
| Theoretical pI
| 7.67 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Matrix metalloproteinase-19
MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPEDITEALRAF
QEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLPSTL
PPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVLAHA
DIPELGSVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPH
FKLHPDDVAGIQALYGKKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGP
RGKTYAFKGDYVWTVSDSGPGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRY
INFKMSPGFPKKLNRVEPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYPKPIKG
LFTGVPNQPSAAMSWQDGRVYFFKGKVYWRLNQQLRVEKGYPRNISHNWMHCRPRTIDTT
PSGGNTTPSGTGITLDTTLSATETTFEY
|
| External Links |
|---|
| GenBank ID Protein
| 1702930 |
| UniProtKB/Swiss-Prot ID
| Q99542 |
| UniProtKB/Swiss-Prot Entry Name
| MMP19_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Y08622 |
| GeneCard ID
| MMP19 |
| GenAtlas ID
| MMP19 |
| HGNC ID
| HGNC:7165 |
| References |
|---|
| General References
| Not Available |