| Identification |
|---|
| HMDB Protein ID
| CDBP03020 |
| Secondary Accession Numbers
| Not Available |
| Name
| Matrix metalloproteinase-17 |
| Description
| Not Available |
| Synonyms
|
- MMP-17
- MT-MMP 4
- MT4-MMP
- MT4MMP
- MTMMP4
- Membrane-type matrix metalloproteinase 4
- Membrane-type-4 matrix metalloproteinase
|
| Gene Name
| MMP17 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in metalloendopeptidase activity |
| Specific Function
| Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin |
| GO Classification
|
| Component |
| extracellular region part |
| extracellular matrix |
| Function |
| metallopeptidase activity |
| calcium ion binding |
| endopeptidase activity |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| hydrolase activity |
| transition metal ion binding |
| zinc ion binding |
| metalloendopeptidase activity |
| peptidase activity |
| peptidase activity, acting on l-amino acid peptides |
| Process |
| metabolic process |
| macromolecule metabolic process |
| protein metabolic process |
| proteolysis |
|
| Cellular Location
|
- Lipid-anchor
- GPI-anchor
- Secreted
- extracellular space
- Extracellular side
- extracellular matrix
- Isoform Long:Cell membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12q24.3 |
| SNPs
| MMP17 |
| Gene Sequence
|
>1812 bp
ATGCGGCGCCGCGCAGCCCGGGGACCCGGCCCGCCGCCCCCAGGGCCCGGACTCTCGCGG
CTGCCGCTGCCGCTGCTGCTGCTGCTGGCGCTGGGGACCCGCGGGGGCTGCGCCGCGCCC
GCACCCGCGCCGCGCGCCGAGGACCTCAGCCTGGGAGTGGAGTGGCTAAGCAGGTTCGGT
TACCTGCCCCCGGCTGACCCCACAACAGGGCAGCTGCAGACGCAAGAGGAGCTGTCTAAG
GCCATCACAGCCATGCAGCAGTTTGGTGGCCTGGAGGCCACCGGCATCCTGGACGAGGCC
ACCCTGGCCCTGATGAAAACCCCACGCTGCTCCCTGCCAGACCTCCCTGTCCTGACCCAG
GCTCGCAGGAGACGCCAGGCTCCAGCCCCCACCAAGTGGAACAAGAGGAACCTGTCGTGG
AGGGTCCGGACGTTCCCACGGGACTCACCACTGGGGCACGACACGGTGCGTGCACTCATG
TACTACGCCCTCAAGGTCTGGAGCGACATTGCGCCCCTGAACTTCCACGAGGTGGCGGGC
AGCGCCGCCGACATCCAGATCGACTTCTCCAAGGCCGACCATAACGACGGCTACCCCTTC
GACGGCCCCGGCGGCACCGTGGCCCACGCCTTCTTCCCCGGCCACCACCACACCGCCGGG
GACACCCACTTTGACGATGACGAGGCCTGGACCTTCCGCTCCTCGGATGCCCACGGGATG
GACCTGTTTGCAGTGGCTGTCCACGAGTTTGGCCACGCCATTGGGTTAAGCCATGTGGCC
GCTGCACACTCCATCATGCGGCCGTACTACCAGGGCCCGGTGGGTGACCCGCTGCGCTAC
GGGCTCCCCTACGAGGACAAGGTGCGCGTCTGGCAGCTGTACGGTGTGCGGGAGTCTGTG
TCTCCCACGGCGCAGCCCGAGGAGCCTCCCCTGCTGCCGGAGCCCCCAGACAACCGGTCC
AGCGCCCCGCCCAGGAAGGACGTGCCCCACAGATGCAGCACTCACTTTGACGCGGTGGCC
CAGATCCGGGGTGAAGCTTTCTTCTTCAAAGGCAAGTACTTCTGGCGGCTGACGCGGGAC
CGGCACCTGGTGTCCCTGCAGCCGGCACAGATGCACCGCTTCTGGCGGGGCCTGCCGCTG
CACCTGGACAGCGTGGACGCCGTGTACGAGCGCACCAGCGACCACAAGATCGTCTTCTTT
AAAGGAGACAGGTACTGGGTGTTCAAGGACAATAACGTAGAGGAAGGATACCCGCGCCCC
GTCTCCGACTTCAGCCTCCCGCCTGGCGGCATCGACGCTGCCTTCTCCTGGGCCCACAAT
GACAGGACTTATTTCTTTAAGGACCAGCTGTACTGGCGCTACGATGACCACACGAGGCAC
ATGGACCCCGGCTACCCCGCCCAGAGCCCCCTGTGGAGGGGTGTCCCCAGCACGCTGGAC
GACGCCATGCGCTGGTCCGACGGTGCCTCCTACTTCTTCCGTGGCCAGGAGTACTGGAAA
GTGCTGGATGGCGAGCTGGAGGTGGCACCCGGGTACCCACAGTCCACGGCCCGGGACTGG
CTGGTGTGTGGAGACTCACAGGCCGATGGATCTGTGGCTGCGGGCGTGGACGCGGCAGAG
GGGCCCCGCGCCCCTCCAGGACAACATGACCAGAGCCGCTCGGAGGACGGTTACGAGGTC
TGCTCATGCACCTCTGGGGCATCCTCTCCCCCGGGGGCCCCAGGCCCACTGGTGGCTGCC
ACCATGCTGCTGCTGCTGCCGCCACTGTCACCAGGCGCCCTGTGGACAGCGGCCCAGGCC
CTGACGCTATGA
|
| Protein Properties |
|---|
| Number of Residues
| 603 |
| Molecular Weight
| 66652.2 |
| Theoretical pI
| 6.55 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Matrix metalloproteinase-17
MRRRAARGPGPPPPGPGLSRLPLPLLLLLALGTRGGCAAPAPAPRAEDLSLGVEWLSRFG
YLPPADPTTGQLQTQEELSKAITAMQQFGGLEATGILDEATLALMKTPRCSLPDLPVLTQ
ARRRRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAG
SAADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRSSDAHGM
DLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRESV
SPTAQPEEPPLLPEPPDNRSSAPPRKDVPHRCSTHFDAVAQIRGEAFFFKGKYFWRLTRD
RHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRP
VSDFSLPPGGIDAAFSWAHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQSPLWRGVPSTLD
DAMRWSDGASYFFRGQEYWKVLDGELEVAPGYPQSTARDWLVCGDSQADGSVAAGVDAAE
GPRAPPGQHDQSRSEDGYEVCSCTSGASSPPGAPGPLVAATMLLLLPPLSPGALWTAAQA
LTL
|
| External Links |
|---|
| GenBank ID Protein
| 112382270 |
| UniProtKB/Swiss-Prot ID
| Q9ULZ9 |
| UniProtKB/Swiss-Prot Entry Name
| MMP17_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_016155.4 |
| GeneCard ID
| MMP17 |
| GenAtlas ID
| MMP17 |
| HGNC ID
| HGNC:7163 |
| References |
|---|
| General References
| Not Available |