| Identification |
|---|
| HMDB Protein ID
| CDBP02999 |
| Secondary Accession Numbers
| Not Available |
| Name
| Latrophilin-2 |
| Description
| Not Available |
| Synonyms
|
- CIRL-2
- Calcium-independent alpha-latrotoxin receptor 2
- Latrophilin homolog 1
- Lectomedin-1
|
| Gene Name
| LPHN2 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in transmembrane receptor activity |
| Specific Function
| Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Function |
| binding |
| receptor activity |
| transmembrane receptor activity |
| molecular transducer activity |
| signal transducer activity |
| g-protein coupled receptor activity |
| carbohydrate binding |
| sugar binding |
| Process |
| g-protein coupled receptor protein signaling pathway |
| neuropeptide signaling pathway |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p31.1 |
| SNPs
| LPHN2 |
| Gene Sequence
|
>4212 bp
ATGGTGTCTTCTGGTTGCAGAATGCGAAGTCTGTGGTTTATCATTGTAATCAGCTTCTTA
CCAAATACAGAAGGTTTCAGCAGAGCAGCTTTACCATTTGGGCTGGTGAGGCGAGAATTA
TCCTGTGAAGGTTATTCTATAGATCTGCGATGCCCGGGCAGTGATGTCATCATGATTGAG
AGCGCTAACTATGGTCGGACGGATGACAAGATTTGTGATGCTGACCCATTTCAGATGGAG
AATACAGACTGCTACCTCCCCGATGCCTTCAAAATTATGACTCAAAGGTGCAACAATCGA
ACACAGTGTATAGTAGTTACTGGGTCAGATGTGTTTCCTGATCCATGTCCTGGAACATAC
AAATACCTTGAAGTCCAATATGAATGTGTCCCTTACATTTTTGTGTGTCCTGGGACCTTG
AAAGCAATTGTGGACTCACCATGTATATATGAAGCTGAACAAAAGGCGGGTGCTTGGTGC
AAGGACCCTCTTCAGGCTGCAGATAAAATTTATTTCATGCCCTGGACTCCCTATCGTACC
GATACTTTAATAGAATATGCTTCTTTAGAAGATTTCCAAAATAGTCGCCAAACAACAACA
TATAAACTTCCAAATCGAGTAGATGGTACTGGATTTGTGGTGTATGATGGTGCTGTCTTC
TTTAACAAAGAAAGAACGAGGAATATTGTGAAATTTGACTTGAGGACTAGAATTAAGAGT
GGCGAGGCCATAATTAACTATGCCAACTACCATGATACCTCACCATACAGATGGGGAGGA
AAGACTGATATCGACCTAGCAGTTGATGAAAATGGTTTATGGGTCATTTACGCCACTGAA
CAGAACAATGGAATGATAGTTATTAGCCAGCTGAATCCATACACTCTTCGATTTGAAGCA
ACGTGGGAGACTGTATACGACAAACGTGCCGCATCAAATGCTTTTATGATATGCGGAGTC
CTCTATGTGGTTAGGTCAGTTTATCAAGACAATGAAAGTGAAACAGGCAAGAACTCAATT
GATTACATTTATAATACCCGATTAAACCGAGGAGAATATGTAGATGTTCCCTTCCCCAAC
CAGTATCAGTATATTGCTGCAGTGGATTACAATCCAAGAGATAACCAACTTTACGTGTGG
AACAATAACTTCATTTTACGATATTCTCTGGAGTTTGGTCCACCTGATCCTGCCCAAGTG
CCTACCACAGCTGTGACAATAACTTCTTCAGCTGAGCTGTTCAAAACCATAATATCAACC
ACAAGCACTACTTCACAGAAAGGCCCCATGAGCACAACTGTAGCTGGATCACAGGAAGGA
AGCAAAGGGACAAAACCACCTCCAGCAGTTTCTACAACCAAAATTCCACCTATAACAAAT
ATTTTTCCCCTGCCAGAGAGATTCTGTGAAGCATTAGACTCCAAGGGGATAAAGTGGCCT
CAGACACAAAGGGGAATGATGGTTGAACGACCATGCCCTAAGGGAACAAGAGGAACTGCC
TCATATCTCTGCATGATTTCCACTGGAACATGGAACCCTAAGGGCCCCGATCTTAGCAAC
TGTACCTCACACTGGGTGAATCAGCTGGCTCAGAAGATCAGAAGCGGAGAAAATGCTGCT
AGTCTTGCCAATGAACTGGCTAAACATACCAAAGGGCCAGTGTTTGCTGGGGATGTAAGT
TCTTCAGTGAGATTGATGGAGCAGTTGGTGGACATCCTTGATGCACAGCTGCAGGAACTG
AAACCTAGTGAAAAAGATTCAGCTGGACGGAGTTATAACAAGGCAATTGTTGACACAGTG
GACAACCTTCTGAGACCTGAAGCTTTGGAATCATGGAAACATATGAATTCTTCTGAACAA
GCACATACTGCAACAATGTTACTCGATACATTGGAAGAAGGAGCTTTTGTCCTAGCTGAC
AATCTTTTAGAACCAACAAGGGTCTCAATGCCCACAGAAAATATTGTCCTGGAAGTTGCC
GTACTCAGTACAGAAGGACAGATCCAAGACTTTAAATTTCCTCTGGGCATCAAAGGAGCA
GGCAGCTCAATCCAACTGTCCGCAAATACCGTCAAACAGAACAGCAGGAATGGGCTTGCA
AAGTTGGTGTTCATCATTTACCGGAGCCTGGGACAGTTCCTTAGTACAGAAAATGCAACC
ATTAAACTGGGTGCTGATTTTATTGGTCGTAATAGCACCATTGCAGTGAACTCTCACGTC
ATTTCAGTTTCAATCAATAAAGAGTCCAGCCGAGTATACCTGACTGATCCTGTGCTTTTT
ACCCTGCCACACATTGATCCTGACAATTATTTCAATGCAAACTGCTCCTTCTGGAACTAC
TCAGAGAGAACTATGATGGGATATTGGTCTACCCAGGGCTGCAAGCTGGTTGACACTAAT
AAAACTCGAACAACGTGTGCATGCAGCCACCTAACCAATTTTGCAATTCTCATGGCCCAC
AGGGAAATTGCATATAAAGATGGCGTTCATGAATTACTTCTTACAGTCATCACCTGGGTG
GGAATTGTCATTTCCCTTGTTTGCCTGGCTATCTGCATCTTCACCTTCTGCTTTTTCCGT
GGCCTACAGAGTGACCGAAATACTATTCACAAGAACCTTTGTATCAACCTTTTCATTGCT
GAATTTATTTTCCTAATAGGCATTGATAAGACAAAATATGCGATTGCATGCCCAATATTT
GCAGGACTTCTACACTTTTTCTTTTTGGCAGCTTTTGCTTGGATGTGCCTAGAAGGTGTG
CAGCTCTACCTAATGTTAGTTGAAGTTTTTGAAAGTGAATATTCAAGGAAAAAATATTAC
TATGTTGCTGGTTACTTGTTTCCTGCCACAGTGGTTGGAGTTTCAGCTGCTATTGACTAT
AAGAGCTATGGAACAGAAAAAGCTTGCTGGCTTCATGTTGATAACTACTTTATATGGAGC
TTCATTGGACCTGTTACCTTCATTATTCTGCTAAATATTATCTTCTTGGTGATCACATTG
TGCAAAATGGTGAAGCATTCAAACACTTTGAAACCAGATTCTAGCAGGTTGGAAAACATT
AAGTCTTGGGTGCTTGGCGCTTTCGCTCTTCTGTGTCTTCTTGGCCTCACCTGGTCCTTT
GGGTTGCTTTTTATTAATGAGGAGACTATTGTGATGGCATATCTCTTCACTATATTTAAT
GCTTTCCAGGGAGTGTTCATTTTCATCTTTCACTGTGCTCTCCAAAAGAAAGTACGAAAA
GAATATGGCAAGTGCTTCAGACACTCATACTGCTGTGGAGGCCTCCCAACTGAGAGTCCC
CACAGTTCAGTGAAGGCATCAACCACCAGAACCAGTGCTCGCTATTCCTCTGGCACACAG
AGTCGTATAAGAAGAATGTGGAATGATACTGTGAGAAAACAATCAGAATCTTCTTTTATC
TCAGGTGACATCAATAGCACTTCAACACTTAATCAAGGACATTCACTGAACAATGCCAGG
GATACAAGTGCCATGGATACTCTACCGCTAAATGGTAATTTTAACAACAGCTACTCGCTG
CACAAGGGTGACTATAATGACAGCGTGCAAGTTGTGGACTGTGGACTAAGTCTGAATGAT
ACTGCTTTTGAGAAAATGATCATTTCAGAATTAGTGCACAACAACTTACGGGGCAGCAGC
AAGACTCACAACCTCGAGCTCACGCTACCAGTCAAACCTGTGATTGGAGGTAGCAGCAGT
GAAGATGATGCTATTGTGGCAGATGCTTCATCTTTAATGCACAGCGACAACCCAGGGCTG
GAGCTCCATCACAAAGAACTCGAGGCACCACTTATTCCTCAGCGGACTCACTCCCTTCTG
TACCAACCCCAGAAGAAAGTGAAGTCCGAGGGAACTGACAGCTATGTCTCCCAACTGACA
GCAGAGGCTGAAGATCACCTACAGTCCCCCAACAGAGACTCTCTTTATACAAGCATGCCC
AATCTTAGAGACTCTCCCTATCCGGAGAGCAGCCCTGACATGGAAGAAGACCTCTCTCCC
TCCAGGAGGAGTGAGAATGAGGACATTTACTATAAAAGCATGCCAAATCTTGGAGCTGGC
CATCAGCTTCAGATGTGCTACCAGATCAGCAGGGGCAATAGTGATGGTTATATAATCCCC
ATTAACAAAGAAGGGTGTATTCCAGAAGGAGATGTTAGAGAAGGACAAATGCAGCTGGTT
ACAAGTCTTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 1459 |
| Molecular Weight
| 163347.4 |
| Theoretical pI
| 6.39 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["852-872", "881-901", "908-928", "953-973", "991-1011", "1038-1058", "1063-1083"]
|
| Protein Sequence
|
>Latrophilin-2
MVSSGCRMRSLWFIIVISFLPNTEGFSRAALPFGLVRRELSCEGYSIDLRCPGSDVIMIE
SANYGRTDDKICDADPFQMENTDCYLPDAFKIMTQRCNNRTQCIVVTGSDVFPDPCPGTY
KYLEVQYECVPYIFVCPGTLKAIVDSPCIYEAEQKAGAWCKDPLQAADKIYFMPWTPYRT
DTLIEYASLEDFQNSRQTTTYKLPNRVDGTGFVVYDGAVFFNKERTRNIVKFDLRTRIKS
GEAIINYANYHDTSPYRWGGKTDIDLAVDENGLWVIYATEQNNGMIVISQLNPYTLRFEA
TWETVYDKRAASNAFMICGVLYVVRSVYQDNESETGKNSIDYIYNTRLNRGEYVDVPFPN
QYQYIAAVDYNPRDNQLYVWNNNFILRYSLEFGPPDPAQVPTTAVTITSSAELFKTIIST
TSTTSQKGPMSTTVAGSQEGSKGTKPPPAVSTTKIPPITNIFPLPERFCEALDSKGIKWP
QTQRGMMVERPCPKGTRGTASYLCMISTGTWNPKGPDLSNCTSHWVNQLAQKIRSGENAA
SLANELAKHTKGPVFAGDVSSSVRLMEQLVDILDAQLQELKPSEKDSAGRSYNKLQKREK
TCRAYLKAIVDTVDNLLRPEALESWKHMNSSEQAHTATMLLDTLEEGAFVLADNLLEPTR
VSMPTENIVLEVAVLSTEGQIQDFKFPLGIKGAGSSIQLSANTVKQNSRNGLAKLVFIIY
RSLGQFLSTENATIKLGADFIGRNSTIAVNSHVISVSINKESSRVYLTDPVLFTLPHIDP
DNYFNANCSFWNYSERTMMGYWSTQGCKLVDTNKTRTTCACSHLTNFAILMAHREIAYKD
GVHELLLTVITWVGIVISLVCLAICIFTFCFFRGLQSDRNTIHKNLCINLFIAEFIFLIG
IDKTKYAIACPIFAGLLHFFFLAAFAWMCLEGVQLYLMLVEVFESEYSRKKYYYVAGYLF
PATVVGVSAAIDYKSYGTEKACWLHVDNYFIWSFIGPVTFIILLNIIFLVITLCKMVKHS
NTLKPDSSRLENIKSWVLGAFALLCLLGLTWSFGLLFINEETIVMAYLFTIFNAFQGVFI
FIFHCALQKKVRKEYGKCFRHSYCCGGLPTESPHSSVKASTTRTSARYSSGTQSRIRRMW
NDTVRKQSESSFISGDINSTSTLNQGMTGNYLLTNPLLRPHGTNNPYNTLLAETVVCNAP
SAPVFNSPGHSLNNARDTSAMDTLPLNGNFNNSYSLHKGDYNDSVQVVDCGLSLNDTAFE
KMIISELVHNNLRGSSKTHNLELTLPVKPVIGGSSSEDDAIVADASSLMHSDNPGLELHH
KELEAPLIPQRTHSLLYQPQKKVKSEGTDSYVSQLTAEAEDHLQSPNRDSLYTSMPNLRD
SPYPESSPDMEEDLSPSRRSENEDIYYKSMPNLGAGHQLQMCYQISRGNSDGYIIPINKE
GCIPEGDVREGQMQLVTSL
|
| External Links |
|---|
| GenBank ID Protein
| 6912464 |
| UniProtKB/Swiss-Prot ID
| O95490 |
| UniProtKB/Swiss-Prot Entry Name
| LPHN2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_012302 |
| GeneCard ID
| LPHN2 |
| GenAtlas ID
| LPHN2 |
| HGNC ID
| HGNC:18582 |
| References |
|---|
| General References
| Not Available |